Zobrazeno 1 - 10
of 553
pro vyhledávání: '"E, McDonough"'
Autor:
Mihaela Pavličev, Caitlin E. McDonough-Goldstein, Andreja Moset Zupan, Lisa Muglia, Yueh-Chiang Hu, Fansheng Kong, Nagendra Monangi, Gülay Dagdas, Nina Zupančič, Jamie Maziarz, Debora Sinner, Ge Zhang, Günter Wagner, Louis Muglia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The common human SNP rs3820282 is associated with multiple phenotypes including gestational length and likelihood of endometriosis and cancer, presenting a paradigmatic pleiotropic variant. Deleterious pleiotropic mutations cause the co-occu
Externí odkaz:
https://doaj.org/article/cadb3fc3e4c1402b819437bdad61dc1a
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Autor:
Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang, Xiting Yan
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Single-cell RNA sequencing (scRNA-seq) technology has enabled assessment of transcriptome-wide changes at single-cell resolution. Due to the heterogeneity in environmental exposure and genetic background across subjects, subject e
Externí odkaz:
https://doaj.org/article/98bb000233a34cca8225fba23b3cf131
Autor:
Tobias Heigl, Janne Kaes, Celine Aelbrecht, Jef Serré, Yoshito Yamada, Vincent Geudens, Anke Van Herck, Arno Vanstapel, Annelore Sacreas, Sofie Ordies, Anna Frick, Berta Saez Gimenez, Jan Van Slambrouck, Hanne Beeckmans, Nilüfer A. Acet Oztürk, Michaela Orlitova, Annemie Vaneylen, Sandra Claes, Dominique Schols, Greetje Vande Velde, Jonas Schupp, Naftali Kaminski, Markus Boesch, Hannelie Korf, Schalk van der Merwe, Lieven Dupont, Jeroen Vanoirbeek, Laurent Godinas, Dirk E. Van Raemdonck, Wim Janssens, Ghislaine Gayan-Ramirez, Laurens J. Ceulemans, John E. McDonough, Erik K. Verbeken, Robin Vos, Bart M. Vanaudenaerde
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic rejection is a major complication post-transplantation. Within lung transplantation, chronic rejection was considered as airway centred. Chronic Lung Allograft Dysfunction (CLAD), defined to cover all late chronic complications, m
Externí odkaz:
https://doaj.org/article/523cb3938ed14de6b83dbb256d799395
Autor:
Pieterjan Kerckhof, Gene P.L. Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens, Saskia Bos, Lynn Willems, Astrid Vermaut, Marie Vermant, Tinne Goos, Charlotte De Fays, Lucia Aversa, Yousry Mohamady, Arno Vanstapel, Michaela Orlitová, Jan Van Slambrouck, Xin Jin, Vimi Varghese, Iván Josipovic, Matthieu N. Boone, Lieven J. Dupont, Birgit Weynand, Adriana Dubbeldam, Dirk E. Van Raemdonck, Laurens J. Ceulemans, Ghislaine Gayan-Ramirez, Laurens J. De Sadeleer, John E. McDonough, Bart M. Vanaudenaerde, Robin Vos
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105030- (2024)
Summary: Background: Chronic lung allograft dysfunction (CLAD) encompasses three main phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and a Mixed phenotype combining both pathologies. How the airway structure
Externí odkaz:
https://doaj.org/article/74c39f4f6a8f4b25a9a6b0237861612e
Autor:
Nora C Brown, Benjamin Gordon, Caitlin E McDonough-Goldstein, Snigdha Misra, Geoffrey D Findlay, Andrew G Clark, Mariana Federica Wolfner
Publikováno v:
eLife, Vol 12 (2023)
In Drosophila melanogaster and other insects, the seminal fluid proteins (SFPs) and male sex pheromones that enter the female with sperm during mating are essential for fertility and induce profound post-mating effects on female physiology. The SFPs
Externí odkaz:
https://doaj.org/article/eb5c76eefee346ccae349db454c40fcc
Autor:
Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut, Tinne Goos, Marie Vermant, Hanne Beeckmans, Janne Kaes, Jan Van Slambrouck, Yousry Mohamady, Lynn Willems, Lucia Aversa, Emanuela E. Cortesi, Charlotte Hooft, Gitte Aerts, Celine Aelbrecht, Stephanie Everaerts, John E. McDonough, Laurens J. De Sadeleer, Sophie Gohy, Jerome Ambroise, Wim Janssens, Laurens J. Ceulemans, Dirk Van Raemdonck, Robin Vos, Tillie L. Hackett, James C. Hogg, Naftali Kaminski, Ghislaine Gayan-Ramirez, Charles Pilette, Bart M. Vanaudenaerde
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
RationaleCOPD is characterized by chronic airway inflammation, small airways changes, with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The chronology by which these three features evolve with altered mucosal immun
Externí odkaz:
https://doaj.org/article/101061ce7f3f4ec7b9919abd90367f9a
Autor:
Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang, Xiting Yan
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3da99a1637a2445db9e02f0e0409547c
Autor:
Farida Ahangari, Nathan L. Price, Shipra Malik, Maurizio Chioccioli, Thomas Bärnthaler, Taylor S. Adams, Jooyoung Kim, Sai Pallavi Pradeep, Shuizi Ding, Carlos Cosmos Jr., Kadi-Ann S. Rose, John E. McDonough, Nachelle R. Aurelien, Gabriel Ibarra, Norihito Omote, Jonas C. Schupp, Giuseppe DeIuliis, Julian A. Villalba Nunez, Lokesh Sharma, Changwan Ryu, Charles S. Dela Cruz, Xinran Liu, Antje Prasse, Ivan Rosas, Raman Bahal, Carlos Fernández-Hernando, Naftali Kaminski
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent findings have shown a marked metabolic reprogramming associated with changes in mitochondrial homeostasis and autophagy during pulmonary fibrosis. The microRNA-
Externí odkaz:
https://doaj.org/article/8e344ceda710493a941fd128cb400f5b
Autor:
Maor Sauler, John E. McDonough, Taylor S. Adams, Neeharika Kothapalli, Thomas Barnthaler, Rhiannon B. Werder, Jonas C. Schupp, Jessica Nouws, Matthew J. Robertson, Cristian Coarfa, Tao Yang, Maurizio Chioccioli, Norihito Omote, Carlos Cosme, Sergio Poli, Ehab A. Ayaub, Sarah G. Chu, Klaus H. Jensen, Jose L. Gomez, Clemente J. Britto, Micha Sam B. Raredon, Laura E. Niklason, Andrew A. Wilson, Pascal N. Timshel, Naftali Kaminski, Ivan O. Rosas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Chronic obstructive pulmonary disease is a leading cause of death worldwide, while our understanding of cell-specific mechanisms underlying its pathobiology remains incomplete. Here the authors perform scRNA-seq of human lung tissue to identify trans
Externí odkaz:
https://doaj.org/article/3579d31a63b3485fb4b3e87914915625
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Oocyte composition can directly influence offspring fitness, particularly in oviparous species such as most insects, where it is the primary form of parental investment. Oocyte production is also energetically costly, dependent on female con
Externí odkaz:
https://doaj.org/article/9d2b801343104da29640fbe42487d16a