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Autor:
B. J. Sedgmen, L. Papalia, L. Wang, A. R. Dyson, H. A. McCallum, C. M. Simson, M. J. Pearse, E. Maraskovsky, D. Hung, P. P. Eomois, G. Hartel, M. J. Barnden, S. P. Rockman
Publikováno v:
Clinical and Developmental Immunology, Vol 2013 (2013)
The measurement of vaccine-induced humoral and CD4+ and CD8+ cellular immune responses represents an important correlate of vaccine efficacy. Accurate and reliable assays evaluating such responses are therefore critical during the clinical developmen
Externí odkaz:
https://doaj.org/article/715b2a08a42944a990cc023b49165e4e
Autor:
A.B. Morelli, E. Maraskovsky
The ISCOMATRIX adjuvant is composed of purified fractions of Quillaja saponaria extract formulated with cholesterol and phospholipid to form cagelike structures of approximately 40–50 nm diameter. Antigens (Ags) can be formulated with ISCOMATRIX ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6595db43419672e86cd7c86c601d656a
https://doi.org/10.1016/b978-0-12-804019-5.00016-5
https://doi.org/10.1016/b978-0-12-804019-5.00016-5
Autor:
E. Maraskovsky, J. L. Smith, M. Schoenborn, Marc K. Jenkins, C. R. Maliszewski, Bali Pulendran
Publikováno v:
The Journal of Experimental Medicine
Injections of soluble proteins are poorly immunogenic, and often elicit antigen-specific tolerance. The mechanism of this phenomenon has been an enduring puzzle, but it has been speculated that tolerance induction may be due to antigen presentation b
Autor:
B Pulendran, J Lingappa, M K Kennedy, J Smith, M Teepe, A Rudensky, C R Maliszewski, E Maraskovsky
Publikováno v:
The Journal of Immunology. 159:2222-2231
We have recently shown that Flt3 ligand administration dramatically increases dendritic cell (DC) numbers in various mouse tissues. This has enabled the identification of distinct mature DC subpopulations. These have been designated: population C (CD
Publikováno v:
The Journal of Immunology. 157:5315-5323
Mice genetically deficient in IL-7R(alpha) are highly lymphopenic in the peripheral lymphoid organs. The functional competence of T cells that have developed in the absence of an IL-7R signal was investigated. Three important observations were made u
Autor:
Brian C. Gliniak, E Maraskovsky, Philip J. Morrissey, D E Williams, J J Peschon, F J Ramsdell, J. Meyer, L S Park, C B Ware, Kenneth H. Grabstein, B L Davison, Steven F. Ziegler
Publikováno v:
The Journal of Experimental Medicine
Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the ro
Autor:
H J, McKenna, K L, Stocking, R E, Miller, K, Brasel, T, De Smedt, E, Maraskovsky, C R, Maliszewski, D H, Lynch, J, Smith, B, Pulendran, E R, Roux, M, Teepe, S D, Lyman, J J, Peschon
Publikováno v:
Blood. 95(11)
The ligand for the receptor tyrosine kinase fms-like tyrosine kinase 3 (flt3), also referred to as fetal liver kinase-2 (flk-2), has an important role in hematopoiesis. The flt3 ligand (flt3L) is a growth factor for hematopoietic progenitors and indu
Autor:
E, Maraskovsky, B, Pulendran, K, Brasel, M, Teepe, E R, Roux, K, Shortman, S D, Lyman, H J, McKenna
Publikováno v:
Advances in experimental medicine and biology. 417
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(9)
Herpesvirus saimiri (HVS) is an oncogenic, lymphotropic, gamma-herpesvirus that transforms human and simian T cells in vitro and causes lymphomas and leukemias in various species of New World primates. Nucleotide sequence analysis of the HVS genome r