Zobrazeno 1 - 10
of 424
pro vyhledávání: '"E, Livni"'
Autor:
Jacob M. Hooker, Zhen Chen, Jing Yang, Chongzhao Ran, Hema S. Krishnan, Neil Vasdev, Kenneth Dahl, Steven H. Liang, E. Livni, Vidya Narayanaswami, Thomas Lee Collier, Vadim Bernard-Gauthier, Michael S. Placzek
Publikováno v:
Molecular Pharmaceutics. 15:695-702
Dyshomeostasis or abnormal accumulation of metal ions such as copper, zinc, and iron have been linked to the pathogenesis of multiple neurodegenerative disorders including Alzheimer’s disease (AD) and Huntington’s disease (HD). 5,7-Dichloro-2-((d
Autor:
Ali A. Bonab, Alan J. Fischman, Patrick E. Ciccone, Darin D. Dougherty, E. Livni, Dolly A. Parasrampuria, Thomas J. Spencer, Joseph Biederman, Bertha K. Madras
Publikováno v:
American Journal of Psychiatry. 163:387-395
Objective: The abuse potential of methylphenidate has been related to the drug’s capacity to produce a rapid onset of blockade of the presynaptic dopamine transporter in the brain. An oral once-aday osmotic controlled-release formulation of methylp
Autor:
Bruce G. Jenkins, E. Livni, Francesca Cicchetti, Ole Isacson, Y. Iris Chen, Kelly Canales, Anna-Liisa Brownell, Chris Owen, Meixiang Max Yu, Rosario Sanchez-Pernaute
Publikováno v:
NeuroImage. 20:1064-1075
Neurophysiological studies of the brain in normal and Parkinson's disease (PD) patients have indicated intricate connections for basal ganglia-induced control of signaling into the motor cortex. To investigate if similar mechanisms are controlling fu
Autor:
Kenneth C. Williams, Yin-Ching Iris Chen, Anna-Liisa Brownell, E. Livni, F. Cicchetti, Ole Isacson
Publikováno v:
European Journal of Neuroscience. 15:991-998
We investigated the microglial response to progressive dopamine neuron degeneration using in vivo positron emission tomography (PET) imaging and postmortem analyses in a Parkinson's disease (PD) rat model induced by unilateral (right side) intrastria
Autor:
Alan J. Fischman, John W. Babich, Nathaniel M. Alpert, E. Livni, Peter C. Meltzer, Ali A. Bonab, Bertha K. Madras
Publikováno v:
Synapse. 39:332-342
The E isomer of (123)I-2beta-carbomethoxy-3beta-(4-fluorophenyl)-N-(1-iodoprop-1-en-3-yl)nortropane (Altropane(R)) shows high affinity (IC(50) = 6.62 +/- 0.78 nmol) and selectivity (DA/5-HT = 25) for DAT sites in the striatum. Recently, dynamic SPECT
Autor:
Anna-Liisa Brownell, Joseph T. Coyle, Yin-Ching Iris Chen, E. Livni, Bruce R. Rosen, Bruce G. Jenkins, Friedrich M. Cavagna, Tuong V. Nguyen
Publikováno v:
Synapse. 36:57-65
Receptor supersensitivity is an important concept for understanding neurotransmitter and receptor dynamics. Traditionally, detection of receptor supersensitivity has been performed using autoradiography or positron emission tomography (PET). We show
Publikováno v:
Journal of the European Academy of Dermatology and Venereology. 10:36-41
Autor:
Nathaniel M. Alpert, John W. Babich, Alan J. Fischman, Evan D. Morris, E. Livni, Bradley T. Christian, Ali A. Bonab, Hongbing Hsu, Bertha K. Madras, Stephen Weise
Publikováno v:
Synapse. 24:262-272
Idiopathic Parkinson's disease (PD) is characterized by loss of dopaminergic terminals in the basal ganglia. The cocaine analog, CFT (WIN 35,428), has been shown to bind selectively to the pre-synaptic dopamine transporters and thus represents an imp
Autor:
Nathaniel M. Alpert, John F. Burke, Alan J. Fischman, John W. Babich, Yong M. Yu, E. Livni, Hongbing Hsu, Ronald G. Tompkins, Vernon R. Young
Publikováno v:
Proceedings of the National Academy of Sciences. 93:1841-1846
Positron emission tomography (PET) with L-[methyl-11C]methionine was explored as an in vivo, noninvasive, quantitative method for measuring the protein synthesis rate (PSR) in paraspinal and hind limb muscles of anesthetized dogs. Approximately 25 mC
Autor:
Robert H. Rubin, Alan J. Fischman, Godek Dennis M, Manoj C. Desai, John W. Babich, Robert A. Wilkinson, E. Livni
Publikováno v:
Nuclear Medicine and Biology. 22:31-36
Changes in substance P (SP) receptor concentration have been implicated in neuropsychiatric disorders, Parkinson's disease, arthritis, inflammatory bowel disease and asthma. Since, SP and peptide analogs are rapidly metabolized and do not penetrate i