Discovery of clinically relevant fusions in pediatric cancer

Autor: Stephanie LaHaye, James R. Fitch, Kyle J. Voytovich, Adam C. Herman, Benjamin J. Kelly, Grant E. Lammi, Jeremy A. Arbesfeld, Saranga Wijeratne, Samuel J. Franklin, Kathleen M. Schieffer, Natalie Bir, Sean D. McGrath, Anthony R. Miller, Amy Wetzel, Katherine E. Miller, Tracy A. Bedrosian, Kristen Leraas, Elizabeth A. Varga, Kristy Lee, Ajay Gupta, Bhuvana Setty, Daniel R. Boué, Jeffrey R. Leonard, Jonathan L. Finlay, Mohamed S. Abdelbaki, Diana S. Osorio, Selene C. Koo, Daniel C. Koboldt, Alex H. Wagner, Ann-Kathrin Eisfeld, Krzysztof Mrózek, Vincent Magrini, Catherine E. Cottrell, Elaine R. Mardis, Richard K. Wilson, Peter White

Publikováno v: BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)

Abstract Background Pediatric cancers typically have a distinct genomic landscape when compared to adult cancers and frequently carry somatic gene fusion events that alter gene expression and drive tumorigenesis. Sensitive and specific detection of g

Externí odkaz: https://doaj.org/article/1bf38c799d7f4ba18515aabb9dbe24f1

Synonymous variants that disrupt messenger RNA structure are significantly constrained in the human population

Autor: James L. Li, Peter White, Grant E. Lammi, Harkness Kuck, James Fitch, Jeffrey B.S. Gaither, David M Gordon, Benjamin J. Kelly

Publikováno v: GigaScience

Background The role of synonymous single-nucleotide variants in human health and disease is poorly understood, yet evidence suggests that this class of “silent” genetic variation plays multiple regulatory roles in both transcription and translati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b64a104fec37d07e0a017365f47216
https://doi.org/10.1093/gigascience/giab023

Acknowledgement to Reviewers of Social Sciences in 2019

Autor: Edward A. Fonchingong, Maria Passantino, Victoria Navarre‐jackson, Gabriela Wastl‐walter, Ahlam Lee, Tammy Tajeddini, Naqi Scandurra, Max O. Stoecker, Audrey Macedo, Rachel Roth, Victor W. Pérez‐armendáriz, Ştefan Cristian Gibbs, Frank Ștefănescu‐mihăilă, Leon Blanco Rivero, Bishawjit Malone, Antonia Carabelli, Sarah Pickel, Seyedesmaeil Mrugalska, Prafula Pease, Terézia Roper, Anna Anand, Martin Young, Susan Randle, Graham Harris, Edith Hudec, Anne Laure Hung, Cristina Martín Đorđević, Mario Fook, Hiroaki Keilman, Pia Ponticorvo, Marisa Ferreira, Jayne Osorio, Diane Doidge, Gary Rodrigues, Nadav Perez‐y‐perez, Stefano Paul, Carmen Rosa Gavini, Daniela De, Hariklia D. Škrinjarić, James C. Simonelli, Marion Bowman, John Otis, Snefrid Momsen, Ron Fitzpatrick, Ting Fai Yuan, Anna Lavoie, Antonio Barreto, António Adam, Paun Crohn, Sanghera, Marie Pierre Morgan, Anibal E. Tregua, Chun Sheng Gomes, Simon Cope, Chiara Chan, Tania Csiszár, Annamaria Passini, Carlos Freire Rodriguez‐modroño, Andromachi Tsikouras, David Hollin, Alina Schellekens, Tara Paixão, Dalia Ellis, Diane Maier, Idiano D’auria, Colter Elsabry, Alison Suppa, Christian Schneider, Liisa Ianole, Jona Schenk‐hoppé, Klaudia Snauwaert, Anna D’souza, Sonja Azadi, Peter Seibel, Adam McCaig, Paolo Postigo, Jinhong Yoe, Magdalena Sohaib, Betsy Taylor, Elżbieta Ladd, Silvia Purcell, Jennifer Prior, Darrell Roy, Carole Zuhdi, Brian Grande, Jean Charles Lantz, John Guijarro, David Mandić, Babak Ramlo, Cheryl M. Bradley, Leong Christensen, Stephanie McMahon, Gary Andreasson, Carina Darwin, Angela Shaw, Ben Hino, Andrea Skilodimou, Phillip Medina‐vicent, Esther Veintimilla, Ireneusz Milczarek‐andrzejewska, Dragana Rahimi, Sabina Němec, Jose Javier Blattner, Paul Lipinski, Dimitrios Napal, Hazel Connell, Adekunle Okorie, Sbiljana Dos Reis, Eleanor Testa, Vanda Parada Medina, Jude Ndzifon Klein, M. William, Fiona Gill, Anthony Quinn, William Safonte, Jonas Ciasullo, Erdal Avery, J. I.R.I. Klepp, Robert Magrane, Bettina Shepherd, Chris Prud’homme, Timothy Recio‐menéndez, Lakshman Wiseman, Don Wehr, Kwadwo Agudo Romeo, Ciprian Oke, Natalia Dabija, Nimrod Barbier‐greenland, Melissa Rosado Marzán, Petri Bodén, Monirul Jaakkola, Maciej Kuffer, Richard Smith, Jacquelyn D. Wilcke, Magdalena Raymond, Ronald Barragán‐escandón, John Sytsma, Hariz Hallgrímsdóttir, Osama Soldatic, Libuše Swigon, Rita Benli, Johanna Landrum, Domingo Ricci, Andy Chatzifotiou, David Baviera‐puig, Duane Rodger, Rachel Łopaciuk‐gonczaryk, John Connelly, Grischa Belford, Dmitry Rubira‐garcía, Heather Scott, Abu Bockerman, Carlos Tempelaar, Ana Almeida, Edward Delrosso, Alexis Doberneck, Chirjiv Anderson, Julie Aitken Schewe, Anamarija Grondys, Jasmina Lumley‐sapanski, José A. Ruiz, María J. Ide, Andrea Loughnan, Linnea Bönisch‐brednich, Michael Badulescu, Kay Tiziana, Aleksandar Erokhin, Jelena Walley, Theodora Mannell, Lauren Dvouletý, Seth C. McKendry, Emese Beáta, Tatiana Haas, Margaret Adiletta, Deedra McKee, Penny Milivojevic, Katherine Tyler, Gerardo Meringolo, Marta Campbell, Maria Pia Cava, Helga Hamada, Anatoliy Gonzalez Canche, Clem Herrero‐diz, Jon Hannouf, Kathleen Chen, Dalia Daniel, Sevaste Chell, Greg Stephenson, Giulio Gabriela, Edi Del Cerro Velázquez, Charlotte Blok, Alessandro Štefko, Dirk Ter Avest, Adalbert Falcone, Jennie Kleine, Dominika Miles, Quan Zadra, Jui Hsiang Lentner, Sunah Kimengsi, Gary Rose, Rebecca Goh, Csaba D’adamo, Camilla Camarero‐figuerola, Pilar Puertas Møllersen, Vassilis Karbowski, Claire Love, Beiyi Huang, Ana Margarida Barrett, Larry Nalmpantis, Giuseppina Adusei‐asante, Erika Palos‐sánchez, Diego Galiano, Lasse Bertella, Philippa Venco, Charlie Zippel, Cecilia Ribeiro‐soriano, Nicholas Połom, Theodor Fromm, Vladislav Živanović, Davide Severo, Lorraine Pickard, Tihana Slater, Li Chen, Renata Sillup, Corrado Lochtman, Rand Raciti, Joseph Prus, Łukasz Matuzeviciute, Jozef Cerchione, Louise Hossain, K. H. Ter Horst, An Nevgi, Jenny Necula, Wojciech Buckley, Nico W. Kelly, Shannon Guenther, Vicky Kavish, Christos Rowbottom, Francisco Del Vecchio, Jenevieve Männikkö Barbutiu, Hans Christian Garmann Jona, Dougherty Kewley, Fabiola Salin, Dorin Majic, Amin Mousavi, Marcelo Jorge De Pajares, Ilkka Nkogo, Stephanie Kim, Piotr Puiu, Ugo Ekblom, Colleen Linková, Gerard Cooper, Ien Aragon, Patrick Brewer, Anne Line Dʹamato, Sue Baker, Jen Scott, Wayne Bullaro, Michael Rosen, Alexander Caruso, Vsevolod Kopkin, Claudia E. Heo, Gerasimos T. Sorainen, Sarmistha Makarovič, Stoney Brown, Romina Fukuda, Eveline Charles, Robert Diogo, Araceli Gamo, Mostafa Nash, Eve R. Berntzen, Pasquale Marcello Faraldo Cabana, Oto Humbert, Gillian Abreu, Benjamin Bracci, Wei Shin Levac, Juan M. Magda, Daniel Gill, Alexandra Zelin, Tom Quinlan, Kate David, Neil Fox, Elhassan Erceg, Anna Tseloni, Hynek Roumpos, Daniela Conversi, Roger Lee, José Ramón Sayed, Patrizia Miciuła, John R. Cannito, Andrew Delgado, Manuel Gozdziak, Sheri Gherghina, Kenneth Pentaris, Sirkku Marczak, Cameron T. Whitman, Minna Lammi‐taskula, Isaías González Valero, Peter J. Doñate, Jose Lukic, Xuan Wharton, Beatriz Castro, Tor Eastman, Georgios Bates, Cristiano Schartner, Klaus Reiner Scherer, Rebecca Cruz Salazar, Maddalena Canonico, Maria Medyna, Helen Ayeb‐karlsson, Rebeca Cristina López Gonzalez‐benson, Luis Miguel Rončáková, Rafael Gray, Joseph Murakami, Jesus González‐lópez, Valeria Bostan, Gregory Whitehouse, Jason Eckhardt, Ann Halilovich, Piotr Phillips, Nirmalya Thiamwong, Fernando Sanz‐altamira, Lexie Schermer, Cinzia Zaharijević, Leo Van Huylenbroeck, Charlene Weenik, Diete Von Keyserlingk, Dale T. Soanes‐white, Angela Wołek, Richard Kramers, Mira Kang, Christopher Teignier, Luca Islam, Maarit Jagger, Christina Hook, Roxanne Conti, Jesús Sánchez Marvão Pereira, Paula Villacampa Estiarte, Marc Teixeira, Muhammad Zumeta, Stefan Seiz Puyuelo, Anna Giuffrida, Charles Che Fontana, Kathleen M. Quinn, Kayhan Tang, Alessandra Miron, Marko Velija, Michael Corsini, Karen Soldatos, Luis I. Amelina, Cecilia Matuszak, Grady Roberts, Paula Heyman, Nancy Quarmby, Sergiu Gherghina, Shelly Von Fintel, Roberto Certomà, Sue Sheridan, Jesper Ang, Maria Rita Thakur, Daniel Neven, Lawrence Wiersma‐mosley, Mei Chuan Hunt, Donizete Rodríguez Martín, Odessa Gonzalez‐feliu, Jameson Bridge, Domenico Sutton, Arijit Deckha, Daniele Conway, Anna Vlasblom, Anne M. Foster‐mcgregor, Maneesha Defrancesco, Neil Healey Akearok, Kathrin Zitricky, Sorin Busu, Alfredo Marzal‐felici, Keith Wandosell, Dana Peterson, Christopher Bañón, Isabel Macfarlane, Marcelo Calin, Lisa Berbel‐pineda, Yvette Boas, Mark Ferreira, Salvador García Ayllón Veković, Paulo Delgado‐romero, Maria Perry, Yoshiharu Fusco, Jappe Economou, Heleen Meil, Oláh Kalalahti, Ana Reynaud, Ian Rorie, Jennifer Cabral, Jonathan Koerner, Julia Evers, Beata López‐lópez, Scott Pierrakis, Josée Le Feuvre, Ronet Bader, David L. Morgan, Na Fucà, Janet Henshall Moniz, António Brandão Morea, Kristina Mauerer, Yinxuan Huarita, Elzbieta Gran, Jenny Dalby, Sol García‐machado, Julio C. Price‐wolf, Beth A. Thompson, Geoffrey Buente, Ladda Thijsen, Rezart Hu, Amber García, Roberto Ingwersen, Tina Fisher, Genine Hoornweg, Elisete Dirakis, Jennifer Popoli, Ellie Lee, Nolan Koral Kordova, Kabindra Man Shapiro, Terry V. Shea, Carolina Višnjić, Brigitte Bontje, Ernst Stafford, Konstantinos Kevin, Shifang Taylor, Janni Arcidiacono, Karen Heikkilä, Thomas Laurentsyeva, Jennifer Matijosaitiene, Tomomi Hanf, Ivana Činčera, Gadaf Reyes‐menendez, Stefano Ridaura, Holger Wilkes, Margarida Luis Ubago, Silvia Sari, Barbara Fearnley, Joya Mitchell, Marzena Synnott, Sanja Miller, Sarah Privitera, Javier Mason, Richard Harrison, Helen M. Croog, Eyal Lewinson, Alexandru‐ionut, Elissa Steirer, Katherine Sabol, Etienne Pleace, Panagiotis Tsogas, Kerstin Zbuchea, Zein Muro, Anders Blount, Jessie L. Kubon, Emma Bartkowski, Marta Evelia Aparicio García‐germán, Nadia Giuliani, Octavian Molero, Tammy Sobocińska, Kaija Collins, María Del Mar Alderson, Atiyeh Van Hove, Jill Svobodová, Athanasios Kuttner, Nish Bencivenga, Okechukwu Oncioiu, Dimitra Quam‐wickham, Joselyne Chenane Nobre, Giovanna Birney, Juan Vaezipour, Nick Gil‐lopez, Rodica Ibáñez‐gonzález, Katarzyna Lillard, Qihui Chen, Gemma Dombrowski, Yang Wasileski, Donato Moreau, Sabrina Assante, John Fisher, Karin Martín Aragón, Ken Rockerbie, Anwar Oxford, Marta Shakya, Petr Dundes, Eva Maria Schneickert, Amy White, Wookjae Herman, Tiffany Judit, Henrie Kepaptsoglou, Antonis Adamek, Annouchka Beazley, Lisa E.F. Knight, Ali Emre Benton‐short, Kevin Wei, Andrea Husu, José Luis Russell, M. A.N.C.I.N.I. Toft, Wiebke, Rima Williams, Mack D. Burlacu, Juan J. García‐ruiz, Katja Lockwood, Balihar Santos Silva, Tanja Johansen, Tobias Ijaz, Aneta Pierce, Gary Smardon, Rebecca Schiller, Katy Barnett, Silvia Misra, Gang Li, Dong Holleran, Rachel Mattisson, Ghulam Nackerud, Matej Malekigorji, Silja Klinkenberg, Javier Garcia, Jackie Smoląg, Lucy Williamson, Randy Stoffelen, Carlos Oswald, Brendan Laudal, Andrea Schwenke Wynn, Laura Connelly, Jarosław Neale, Haozhi Panek, Daisuke Muresan, Gaia Goddard, Lena Devaney, Paul Kużelewska, Caterina Arcuri, Terence Lucas, Linda Knowles, Jiri Pankowska, Jessica Ruban, Arye L. Hillman, Gerlinde Mayer, Helana Dashper, Julia Sánchez Sánchez, Markus Gerson, Rainer Ruiperez‐valiente, Marta Serdeira Azevedo, Giulia Carlbom, Jeffrey Henninger, Doris Weaving, Brittany Lange, Leah Lewin, Madhavi Gazzano, Vasilii Ertz, Linda L. Hagell, Nadzeya Lavizzari, Malgorzata Papadakis, Terry Moldovan, Lorraine Siemienska, Sandra Leaton Grbes, María Del Mar Martín, Olegas Niiniluoto, Luis Bar‐am, Miliann Kantamaneni, Brendan Shearer, Raul Naybor, Ionica Ormsbee, Christopher Behr, Heather Sheldon, Róbert Steglich, Victoria Tabe, Teresa Caron, Brandy Collin, R. Elise B. Johnsen, Dragan Pan, Lei Zufferey, Hartmut Beier, Randall Conley, Ramona Olivia Stefanini, José Antonio Rodríguez, Dario Atukeren, Alexander Torell, Hossein Bachman, Frank Li, Gabrielle Joelsson, Marco Borsellino, Ionel Bowl, Maria Clutterbuck, Stamatis Papafilippou, Aje Carlone, Galyna Mees, Ingrid Fu, Elisabetta Maria Verticelli, Ramon Ruiz‐real, Adrian Cantemir Callegari, Adriana Zajda, Michael Holmes, Esther Canosa, Paula Serrano Lopez, Luise Vranješević, Carmel Díaz, Gabriel Mukungu, Reinmar Seifert, Alex Loh, Mareike Klemes, J. Agustin Franklin, Patricia Fawcett, Roswith Roubík, Ian F. Shaw, Dumitru Mironeasa, Pedro Guilherme Rocha Doucek, Silvia Nunn, Martha McReynolds, Suchandra Pavliuk, Ondřej Dybo, John Godderis, Pasquale Delatolla, Alfonso J. Ginès Fabrellas, Kyoung Yim Kim, Art Alfaro, Gregory Toscano‐hernández, Eryk Kostelka, Kostas Konstantinov, Jan Foreman, Maria Vincenza Cimermanová, Antonio Eleazar Sesagiri Raamkumar, Mariusz Uribe‐toril, Fred Mather, Amparo Bayley, Abbas Azhar Abel, Danilo Maniou, Tesseltje De Languilaire, Lauren Dantas, Lena Hoang, Irina Matthews, Melissa Hipp, Paula Romero‐rodríguez, Jan Cipollina, Colin McClearn, Andreas Pieke, Esteban Veen, Stuart Franco, Jerome Reim, Tom Baker‐beall, Tobias Reichman, Marwa Hao, Dora Satybaldieva, Patrick Oakes, Frank Piekut, Muhammad Hoxhaj, Kate Lockwood Harris, Guido Van Nuland, Greg Newton, Donatella Prosser, Muhammad Roberts, Nicky Leakey, Kate Mukuni, Aleksandar Visvizi, Heather Campbell, Venurs Lomonaco‐benzing, Michela Pookulangara, Beata Muinos, Marcin Polsa, Barry Featherstone, David Charlwood, Ying Liczmańska‐kopcewicz, Enrico Bracken, Floyd Ortega‐sánchez, Angela Wyile, Ben Hine, Yannis Piguet, Feng Harman, Ilene Holm, Fernando Álvarez‐gonzález, Elham Baines, Nina Glick Schmidt, Milla Salom‐carrasco, Daniel Lorenzini, Borja Sarapura, Neil Hillman, Jegoo Lee, John Kenneth, Magdalena Mousavi, Layana Navarro, Simona Stadlober, Mark Dolores Molero, Silvia Mostowska, Gonzalo Wang, Marcela Links, Paulo Fetner, Diego Tisdall, Hayley Ratajczak, Adnan Underwood, Dan Cristian Dagg, Johanna Naser, Sebastian Kotter, Daniel R. Kawamura, Melanie D. Ouassini, Samantha Majumdar, Miriam Elizabeth De Filippo, Kimihiro Hinten, Anne Newbold, Paul El Khaled, David A.M. Petrisor, Chang Sup Partalidou, John Lo Storto, Robin Bartzas, Deborah Nazarczuk, Gregorio Rita, Marcin Wright, Catherine Vázquez‐cano, Arie Strang, Tan Meng Young, Muhammad Fazal Impicciatore, Gabriel González, Petrykowski, Bryan Dalsgård, Ana María Rexhepi, Francisco Gurko, Athina Edler, Manuel González Pérez, Adam Katsoni, Katarzyna Grugan, Amanda Thomas, Elizabeth Quinn Wroblewski, Myriam Everitt, George P. Simeon, Gavin Minello, Harriet Brereton, Selma Machimbarrena, Sarah Page, Dimitri Iseppi, Alina Bahmanteymouri, Jong Chan Kim, Orlando Goncharuk, Colleen Xu, Duncan Ul Haque, Joseph Zander, Carol Thompson, Andy Niakšu, Shirley Vanner, James A. Rodin, Relaño Pastor, Jeana Desimone, María Jesús Čentéš, Stephanie Konsolakis, Aimee L. Friedrich, Laura Del Carmen, Haydn Moscatelli, Mihail Butler, Manuel Reese, Jan Dirk Volsche, Harriot Beer, Josiah Hibbert, Predrag Zou, Gyorgy Jones, Panagiotis Perez, Elmira Saura, Neil Petcu, Roman Pearce, Susan Jagosh, Rosemary Carpenter, Anna Krienert, Hillevi Leong, Daniel Hopper, Ingrid Bockarie, Justin Jenkin, Monika Kungolos, Raúl Park, Cavallotti Rizwan, Filip Kot, Christina Henig, Grace R. Burke, Pedro Pamucar, Maria Radicic, Lennart Kapsalis, Sandra Byrne, Alice Brzoska, Mair Urbański, Aldo Mustafa, Michael Brzozowski, Michael Younus, Rosemary Pyrialakou, Encarnación Moral Palmesr, Dennis Edu, Magdalena Markvica, Dora Sanz, Anthony E. Lammi, Juan Manuel Berei, Iulia Cristina Murib, Edna Aliverti, John Bartram, Sigal Kosinski, Justin Detlefsen, Terri Li, Wan Jiun Ching, Antu Sørensen, Constance Fogarty, George Twamley, Laura A. Regner, Dobrotă Galan, Bing Yang, Xiaohe Xue, Hilary Whitley, Angelo Gebhardt, César F. Rose, Manyu Li, Moritz Ioannides, Aravind Settembre Blundo, Lidia Cai, Delfín Osgood, Tal Flanagan, Bernstein, Megan Bittle, Alice Vicente, Kimberly Seidler, Maryam Mallick, Liwen Chen, Bertie Russo, María Närvi, Robert Obrad, Steven Shell‐duncan, Aaron Zhang, Steven Black, Elli Hellmich, Jasmine Löther, Gwen Healy, Ryan Cochrane, Paul Gilhooly, Simon Dale, Ryan D. Wimalasena, Filippo Cristian, Marco Triandafyllidou, Csaba Lenz‐taguchi, Dave Brooks, Clarisa Perez‐vaisvidovsky, Luz Marina Didham, Giulia Casais, Sanjukta Pope, Ninna Nyberg Spanu, Komali Kaplan, Yuzhou Cajias

Publikováno v: Social Sciences, Vol 9, Iss 1, p 6 (2020)

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824271729781620c7c8158303677e377
https://www.mdpi.com/2076-0760/9/1/6

Global Analysis of Human mRNA Folding Disruptions in Synonymous Variants Demonstrates Significant Population Constraint

Autor: Grant E. Lammi, James Fitch, James L. Li, David M Gordon, Benjamin J. Kelly, Jeffrey B.S. Gaither, Peter White, Harkness Kuck

BackgroundIn most organisms the structure of an mRNA molecule is crucial in determining speed of translation, half-life, splicing propensities and final protein configuration. Synonymous variants which distort this wildtype mRNA structure may be path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1203108fe79140146d38563815873238

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