Zobrazeno 1 - 10
of 103
pro vyhledávání: '"E, Hollstein"'
Autor:
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley
Publikováno v:
Cancer Discovery. 13:1002-1025
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac5f4cb166033aae485e34312737576
https://doi.org/10.1158/2159-8290.cd-22-0805
https://doi.org/10.1158/2159-8290.cd-22-0805
Autor:
Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw
Publikováno v:
Science. 380
Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c60372c6d0433474cdd1b48556a27a96
https://doi.org/10.1126/science.abj5559
https://doi.org/10.1126/science.abj5559
Autor:
Lewis C. Cantley, Harold Varmus, Raymond E. Moellering, John M. Asara, Chen Zhang, Reuben J. Shaw, Steven S. Gross, Bryan Ngo, Miriam Sindelar, John S. Coukos, Qiuying Chen, Min Yuan, Roger J. Liang, Pablo E. Hollstein, David Wu, Jae Won Chang, Eric E. Gardner, John R. Ferrarone, Benjamin D. Stein
Figure S3. TPI1 phosphorylation regulates triose phosphate levels and metabolic flux.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e442f21632c30fbcd19a65b226840d4
https://doi.org/10.1158/2159-8290.22553386
https://doi.org/10.1158/2159-8290.22553386
Autor:
Lewis C. Cantley, Harold Varmus, Raymond E. Moellering, John M. Asara, Chen Zhang, Reuben J. Shaw, Steven S. Gross, Bryan Ngo, Miriam Sindelar, John S. Coukos, Qiuying Chen, Min Yuan, Roger J. Liang, Pablo E. Hollstein, David Wu, Jae Won Chang, Eric E. Gardner, John R. Ferrarone, Benjamin D. Stein
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a4888ce7db00a4ab236f555bdd0a96
https://doi.org/10.1158/2159-8290.c.6534613.v2
https://doi.org/10.1158/2159-8290.c.6534613.v2
Autor:
Karen Cichowski, Pablo E. Hollstein
Supplementary Figure 3 - PDF file 65K, CUL3 knockdown stabilizes neurofibromin in GBM cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6e811fcc7f84eade593804b09cbbd9
https://doi.org/10.1158/2159-8290.22529813
https://doi.org/10.1158/2159-8290.22529813
Autor:
Reuben J. Shaw, Rebecca Berdeaux, Robert A. Screaton, Maxim N. Shokhirev, April E. Williams, Hector M. Galvez, Amanda Hutchins, T.J. Rymoff, Debbie S. Ross, Liliana I. Vera, Robert U. Svensson, Anwesh Kamireddy, Sonja N. Brun, Lillian J. Eichner, Pablo E. Hollstein
Supplemental Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004e8302e03d44f61ec3ba546c257239
https://doi.org/10.1158/2159-8290.22532756
https://doi.org/10.1158/2159-8290.22532756
Autor:
Karen Cichowski, Pablo E. Hollstein
Supplementary Figure Legends - PDF file 64K, Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5ce1aa50a51e2f2a2437ee232e0aa
https://doi.org/10.1158/2159-8290.22529810.v1
https://doi.org/10.1158/2159-8290.22529810.v1
Autor:
Karen Cichowski, Pablo E. Hollstein
Supplementary Figure 2 - PDF file 250K, DN-Cul3 stabilizes Cul3 targets regulates neurofibromin-dependent MAPK activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd41813dc72915f1337d0b28efd27fe
https://doi.org/10.1158/2159-8290.22529816
https://doi.org/10.1158/2159-8290.22529816
Autor:
Reuben J. Shaw, Rebecca Berdeaux, Robert A. Screaton, Maxim N. Shokhirev, April E. Williams, Hector M. Galvez, Amanda Hutchins, T.J. Rymoff, Debbie S. Ross, Liliana I. Vera, Robert U. Svensson, Anwesh Kamireddy, Sonja N. Brun, Lillian J. Eichner, Pablo E. Hollstein
Mutations in the LKB1 (also known as STK11) tumor suppressor are the third most frequent genetic alteration in non–small cell lung cancer (NSCLC). LKB1 encodes a serine/threonine kinase that directly phosphorylates and activates 14 AMPK family kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88f344e09faf5fe67fa60dbf2d0358c
https://doi.org/10.1158/2159-8290.c.6546818
https://doi.org/10.1158/2159-8290.c.6546818
Autor:
Pablo E. Hollstein, Eric E Gardner, John Ferrarone, Steven S. Gross, Min Yuan, John S. Coukos, Raymond E. Moellering, Harold E. Varmus, Benjamin D. Stein, Roger Liang, John M. Asara, Bryan Ngo, Lewis C. Cantley, Reuben J. Shaw, Miriam Sindelar, Jae Won Chang, David Wu, Qiuying Chen
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD) and activating mutations in KRAS frequently co-occur with loss-of-function mutations in the tumor suppressor genes, TP53 or STK11/LKB1. However, mutation of all three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e820372a0319e963a998dbfb261b71
https://doi.org/10.1101/2021.10.01.462764
https://doi.org/10.1101/2021.10.01.462764