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Akademický článek

Renal Cell Carcinoma Unclassified with Medullary Phenotype in a Patient with Neurofibromatosis Type 2

Autor: Sanila Sarkar, Whitney Throckmorton, Racheal Bingham, Pavlos Msaouel, Giannicola Genovese, John Slopis, Priya Rao, Zsila Sadighi, Cynthia E. Herzog

Publikováno v: Current Oncology, Vol 30, Iss 3, Pp 3355-3365 (2023)

We present, to our knowledge, the first reported case of germline neurofibromatosis Type 2 (NF2) associated with renal cell carcinoma unclassified with medullary phenotype (RCCU-MP) with somatic loss by immunohistochemistry of the SMARCB1 tumor suppr

Externí odkaz: https://doaj.org/article/d2d4a339ce2f4a6eb08576e2f58c77da

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Akademický článek

Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients

Autor: Linnea E. Herzog, Lei Wang, Eunah Yu, Soonwook Choi, Zohreh Farsi, Bryan J. Song, Jen Q. Pan, Morgan Sheng

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Schizophrenia is a heterogeneous psychiatric disorder with a strong genetic basis, whose etiology and pathophysiology remain poorly understood. Exome sequencing studies have uncovered rare, loss-of-function variants that greatly increase ris

Externí odkaz: https://doaj.org/article/6ef43cb727fa46878a20e353d3dbdbe9

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Akademický článek

Bmi-1: A master regulator of head and neck cancer stemness

Autor: Alexandra E. Herzog, Ritu Somayaji, Jacques E. Nör

Publikováno v: Frontiers in Oral Health, Vol 4 (2023)

Head and neck cancers are composed of a diverse group of malignancies, many of which exhibit an unacceptably low patient survival, high morbidity and poor treatment outcomes. The cancer stem cell (CSC) hypothesis provides an explanation for the subst

Externí odkaz: https://doaj.org/article/58df8f186b9345e39206cc809b1a5133

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Akademický článek

The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells

Autor: Alexandra E. Herzog, Kristy A. Warner, Zhaocheng Zhang, Emily Bellile, Meera A. Bhagat, Rogerio M. Castilho, Gregory T. Wolf, Peter J. Polverini, Alexander T. Pearson, Jacques E. Nör

Publikováno v: Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)

Abstract Despite major progress in elucidating the pathobiology of head and neck squamous cell carcinoma (HNSCC), the high frequency of disease relapse correlates with unacceptably deficient patient survival. We previously showed that cancer stem-lik

Externí odkaz: https://doaj.org/article/3707949541ef4d9b938398d1dec5cc67

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Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)

Publikováno v: Clinical Cancer Research. 29:1708-1718

Purpose: Developing new therapeutics for any of the more than 100 sarcoma subtypes presents a challenge. After progression from standard therapies, patients with sarcoma may be referred for enrollment in early-phase trials. This study aimed to invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78f23ea3e8e64341e0552b9d54de1861
https://doi.org/10.1158/1078-0432.ccr-22-3629

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Akademický článek

Pulpbow: A Method to Study the Vasculogenic Potential of Mesenchymal Stem Cells from the Dental Pulp

Autor: Andrea Mantesso, Zhaocheng Zhang, Kristy A. Warner, Alexandra E. Herzog, Ajai J. Pulianmackal, Jacques E. Nör

Publikováno v: Cells, Vol 10, Iss 11, p 2804 (2021)

Understanding how Mesenchymal Stem Cells (MSCs) form blood vessels is critical for creating mechanism-based approaches for the therapeutic use of these cells. In addition, understanding the determinants and factors involved in lineage hierarchy is fu

Externí odkaz: https://doaj.org/article/2f73ad61635447c5924ac54b3b159172

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