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Akademický článek

Analysis of public perceptions on the use of artificial intelligence in genomic medicine

Autor: Jack E. Harrison, Fiona Lynch, Zornitza Stark, Danya F. Vears

Publikováno v: Human Genomics, Vol 18, Iss 1, Pp 1-9 (2024)

Abstract Purpose Next generation sequencing has led to the creation of large pools of genomic data with analysis rather than data generation now the limiting factor. Artificial intelligence (AI) may be required to optimize the benefits of these data,

Externí odkaz: https://doaj.org/article/ca4c1f798a574316ba1cf511d8534300

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Review

Romantic Catholics. France's Postrevolutionary Generation in Search of a Modem Faith Carol E. Harrison

Autor: Milbach, Sylvain

Publikováno v: Revue d'histoire moderne et contemporaine (1954-), 2017 Oct 01. 64(4), 200-202.

Externí odkaz: https://www.jstor.org/stable/44986704

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Akademický článek

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

Autor: Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Lloyd D W King, Lea K Barfod, Simon J Draper, Ivan Campeotto, Matthew K Higgins

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2539-2559 (2024)

Abstract There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and parasite transmission. Antibodies which target PfRH5 are hi

Externí odkaz: https://doaj.org/article/b942500814154714b2e7a3f058d0d828

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Akademický článek

Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer’s disease

Autor: Katrina Volk Robertson, Alec S. Rodriguez, Jean-Philippe Cartailler, Shristi Shrestha, Michael W. Schleh, Kyle R. Schroeder, Arianna M. Valenti, Alec T. Kramer, Fiona E. Harrison, Alyssa H. Hasty

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-24 (2024)

Abstract Background Microglial cell iron load and inflammatory activation are significant hallmarks of late-stage Alzheimer’s disease (AD). In vitro, microglia preferentially upregulate the iron importer, divalent metal transporter 1 (DMT1, gene na

Externí odkaz: https://doaj.org/article/471d680b763f443b85bdae7d76d2dd8f

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Akademický článek

Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

Autor: Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)

Abstract Background Digital speech assessment has potential relevance in the earliest, preclinical stages of Alzheimer’s disease (AD). We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (Aβ) patholo

Externí odkaz: https://doaj.org/article/75ea7ee6329e4654a1896779b7cc2a38

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