Zobrazeno 1 - 10
of 11 625
pro vyhledávání: '"E, Harris"'
Autor:
Sarah E. Harris, Maria S. Alexis, Gilbert Giri, Francisco F. Cavazos, Yue Hu, Jernej Murn, Maria M. Aleman, Christopher B. Burge, Daniel Dominguez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While evolution is often considered from a DNA- and protein-centric view, RNA-based regulation can also impact gene expression and protein sequences. Here we examine interspecies differences in RNA-protein interactions using the conserved ne
Externí odkaz:
https://doaj.org/article/ce17714e4bec439a9ccd747de9a1cb5d
Autor:
Danni A. Gadd, Hannah M. Smith, Donncha Mullin, Ola Chybowska, Robert F. Hillary, Dorien M. Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell, Danielle Page, Adele Taylor, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Rosie M. Walker, Kathryn L. Evans, Andrew M. McIntosh, Caroline Hayward, Tom C. Russ, Sarah E. Harris, Paul Welsh, Naveed Sattar, Simon R. Cox, Daniel L. McCartney, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-p
Externí odkaz:
https://doaj.org/article/76e8233ab631452ab514eb985f52d351
Publikováno v:
Biogeosciences, Vol 21, Pp 3641-3663 (2024)
Isotopic measurements of trace gases such as N2O, CO2, and CH4 contain valuable information about production and consumption pathways. Quantification of the underlying pathways contributing to variability in isotopic time series can provide answers t
Externí odkaz:
https://doaj.org/article/3177bac048c544fdb388a577b13bbbe0
Autor:
Silas A. Culver, Stefan R. Hargett, Jamie L. L. Q. Balugo, John J. Gildea, Thurl E. Harris, Helmy M. Siragy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract ATP6AP2 knockout in the renal nephron impairs receptor-mediated endocytosis, increasing urinary albumin and glucose excretion and impairing weight gain. Nonesterified fatty acids (NEFA) in urine are bound to albumin and reabsorbed in the pro
Externí odkaz:
https://doaj.org/article/58751f5b9b01401cad3940214306ac52
Autor:
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m
Externí odkaz:
https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135
Autor:
Rodhan Patke, Anna E. Harris, Corinne L. Woodcock, Rachel Thompson, Rute Santos, Amber Kumari, Cinzia Allegrucci, Nathan Archer, Lorraine J. Gudas, Brian D. Robinson, Jenny L. Persson, Rupert Fray, Jennie Jeyapalan, Catrin S. Rutland, Emad Rakha, Srinivasan Madhusudan, Richard D. Emes, Musalwa Muyangwa-Semenova, Mansour Alsaleem, Simone de Brot, William Green, Hari Ratan, Nigel P. Mongan, Jennifer Lothion-Roy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 56, Iss , Pp 101032- (2024)
Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen
Externí odkaz:
https://doaj.org/article/f224ca60609a48d0bd38942bd1a03543
Publikováno v:
JAAD Case Reports, Vol 49, Iss , Pp 65-67 (2024)
Externí odkaz:
https://doaj.org/article/6e2dd6a84b104ae98ffc19dd5538cd22
Autor:
Zhishan Chen, Xingyi Guo, Ran Tao, Jeroen R. Huyghe, Philip J. Law, Ceres Fernandez-Rozadilla, Jie Ping, Guochong Jia, Jirong Long, Chao Li, Quanhu Shen, Yuhan Xie, Maria N. Timofeeva, Minta Thomas, Stephanie L. Schmit, Virginia Díez-Obrero, Matthew Devall, Ferran Moratalla-Navarro, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah E. W. Briggs, Victoria Svinti, Kevin Donnelly, Susan M. Farrington, James Blackmur, Peter G. Vaughan-Shaw, Xiao-Ou Shu, Yingchang Lu, Peter Broderick, James Studd, Tabitha A. Harrison, David V. Conti, Fredrick R. Schumacher, Marilena Melas, Gad Rennert, Mireia Obón-Santacana, Vicente Martín-Sánchez, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John L. Hopper, Mark A. Jenkins, Aung Ko Win, Rish K. Pai, Jane C. Figueiredo, Robert W. Haile, Steven Gallinger, Michael O. Woods, Polly A. Newcomb, David Duggan, Jeremy P. Cheadle, Richard Kaplan, Rachel Kerr, David Kerr, Iva Kirac, Jan Böhm, Jukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri A. Aaltonen, Harri Rissanen, Eero Pukkala, Johan G. Eriksson, Tatiana Cajuso, Ulrika Hänninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Satu Männistö, Demetrius Albanes, Stephanie J. Weinstein, Edward Ruiz-Narvaez, Julie R. Palmer, Daniel D. Buchanan, Elizabeth A. Platz, Kala Visvanathan, Cornelia M. Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter T. Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha L. Slattery, John D. Potter, Kostas K. Tsilidis, Matthias B. Schulze, Marc J. Gunter, Neil Murphy, Antoni Castells, Sergi Castellví-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, D. Timothy Bishop, Graham G. Giles, Melissa C. Southey, Gregory E. Idos, Kevin J. McDonnell, Zomoroda Abu-Ful, Joel K. Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope O. Keku, Bethany van Guelpen, Thomas J. Hudson, Heather Hampel, Rachel Pearlman, Sonja I. Berndt, Richard B. Hayes, Marie Elena Martinez, Sushma S. Thomas, Paul D. P. Pharoah, Susanna C. Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly F. Doheny, Elizabeth Pugh, Tameka Shelford, Andrew T. Chan, Marcia Cruz-Correa, Annika Lindblom, David J. Hunter, Amit D. Joshi, Clemens Schafmayer, Peter C. Scacheri, Anshul Kundaje, Robert E. Schoen, Jochen Hampe, Zsofia K. Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Christopher K. Edlund, W. James Gauderman, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen J. Chanock, Franzel van Duijnhoven, Edith J. M. Feskens, Lori C. Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Barbara Pardini, Liesel M. FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie A. Bien, Charles Kooperberg, Christopher I. Li, Yi Lin, Ross Prentice, Conghui Qu, Stéphane Bézieau, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Loic Le Marchand, Anna H. Wu, Chenxu Qu, Caroline E. McNeil, Gerhard Coetzee, Caroline Hayward, Ian J. Deary, Sarah E. Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Ken S. Lau, Hongyu Zhao, Li Hsu, Qiuyin Cai, Malcolm G. Dunlop, Stephen B. Gruber, Richard S. Houlston, Victor Moreno, Graham Casey, Ulrike Peters, Ian Tomlinson, Wei Zheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all k
Externí odkaz:
https://doaj.org/article/a9c9d74556364a62b1ef09719244a952
Autor:
Pangyu Joo, Minkyung Kim, Brianna Kish, Vidhya Vijayakrishnan Nair, Yunjie Tong, Ziyue Liu, Andrew R. W. O’Brien, Steven E. Harte, Richard E. Harris, UnCheol Lee, Ying Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Sickle cell disease (SCD) is a genetic disorder causing painful and unpredictable Vaso-occlusive crises (VOCs) through blood vessel blockages. In this study, we propose explosive synchronization (ES) as a novel approach to comprehend the hyp
Externí odkaz:
https://doaj.org/article/6ec4a414d51445dba80383c2da802b56
Autor:
Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-Gómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary, James P. Boardman, Donncha S. Mullin, Tom C. Russ, Simon R. Cox, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalis
Externí odkaz:
https://doaj.org/article/3c13220e7e174e5f8add934cd767d03c