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Akademický článek

Hepatocyte mARC1 promotes fatty liver disease

Publikováno v: JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new

Externí odkaz: https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677

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Akademický článek

Fermionic halos at finite temperature in AdS/CFT

Autor: Carlos R. Argüelles, Nicolás E. Grandi

Publikováno v: Journal of High Energy Physics, Vol 2018, Iss 5, Pp 1-15 (2018)

Abstract We explore the gravitational backreaction of a system consisting in a very large number of elementary fermions at finite temperature, in asymptotically AdS space. We work in the hydrodynamic approximation, and solve the Tolman-Oppenheimer-Vo

Externí odkaz: https://doaj.org/article/288b237348f9400691546f620cc1cf8a

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Akademický článek

Fermionic spectral functions in backreacting p-wave superconductors at finite temperature

Autor: G. L. Giordano, N. E. Grandi, A.R. Lugo

Publikováno v: Journal of High Energy Physics, Vol 2017, Iss 4, Pp 1-37 (2017)

Abstract We investigate the spectral function of fermions in a p-wave superconducting state, at finite both temperature and gravitational coupling, using the AdS/CF T correspondence and extending previous research. We found that, for any coupling bel

Externí odkaz: https://doaj.org/article/9b8dfc971dd4455e8c4e62ebeb9d497b

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Akademický článek

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Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+-handling protein variation

Autor: X. Zhang, C.E.R. Smith, S. Morotti, A.G. Edwards, D. Sato, W.E. Louch, H. Ni, E. Grandi

Disruption of the transverse-axial tubule system (TATS) in diseases such as heart failure and atrial fibrillation occurs in combination with changes in the expression and distribution of key Ca2+- handling proteins. Together this ultrastructural and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d868be3832751d7ea51d3aad1f2e7bbf
https://doi.org/10.1101/2022.07.15.500278

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Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation

Autor: X. Zhang, H. Ni, S. Morotti, C.E.R. Smith, D. Sato, W.E. Louch, A.G. Edwards, E. Grandi

Intracellular calcium (Ca2+) cycling is tightly regulated in the healthy heart ensuring effective contraction. This is achieved by transverse (t)-tubule membrane invaginations that facilitate close coupling of key Ca2+-handling proteins such as the L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3305515d636f2244bb544bc46d034ba
https://doi.org/10.1101/2022.07.15.500273

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Akademický článek

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Akademický článek

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Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up

Autor: A.F.G. Cicero, F. Fogacci, E. Rizzoli, M. Giovannini, S. D'Addato, C. Borghi, E. Grandi, F. Ventura, P. Coppola, E. Ianniello, M. Soldati, F.M. Piani, I.R. Iamino, S. Palmisano, M. Landolfo, S. Bacchelli

Publikováno v: Nutrition, metabolism, and cardiovascular diseases : NMCD. 32(9)

To evaluate the long-term effect of simultaneous treatment of hypertension and hypercholesterolemia with angiotensin-converting enzyme (ACE) inhibitors and statins on the incidence of major cardiovascular events (MACE) and other clinical outcomes.We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81b931a6b2285df8b605d7f034a684d
https://pubmed.ncbi.nlm.nih.gov/35843791

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