Zobrazeno 1 - 10
of 474
pro vyhledávání: '"E, Gerszten"'
Autor:
Nilanjana Ghosh, Carl Lejonberg, Tomasz Czuba, Koen Dekkers, Richard Robinson, Johan Ärnlöv, Olle Melander, Maya Landenhed Smith, Anne M. Evans, Olof Gidlöf, Robert E. Gerszten, Lars Lind, Gunnar Engström, Tove Fall, J. Gustav Smith
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Plasma metabolomics holds potential for precision medicine, but limited information is available to compare the performance of such methods across multiple cohorts. We compared plasma metabolite profiles after an overnight fast in 11,309 par
Externí odkaz:
https://doaj.org/article/07c3b0b4011d4fd3972f0e6ac665caac
Autor:
Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Francois Aguet, Kristin G. Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee
Publikováno v:
HGG Advances, Vol 6, Iss 1, Pp 100383- (2025)
Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, mo
Externí odkaz:
https://doaj.org/article/d2ec3098fe5546ea8b66f3dab09da6b7
Autor:
Yi-Ting Tsai, Yana Hrytsenko, Michael Elgart, Usman A. Tahir, Zsu-Zsu Chen, James G. Wilson, Robert E. Gerszten, Tamar Sofer
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100304- (2024)
Summary: Genetic correlation refers to the correlation between genetic determinants of a pair of traits. When using individual-level data, it is typically estimated based on a bivariate model specification where the correlation between the two variab
Externí odkaz:
https://doaj.org/article/7493a82d16f842ec929d7929506e2863
Autor:
Adrienne Tin, Alison E. Fohner, Qiong Yang, Jennifer A. Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V. Lindbohm, Michael R. Duggan, Osorio Meirelles, Sarah E. Harris, Valborg Gudmundsdottir, Adele M. Taylor, Albert Henry, Alexa S. Beiser, Ali Shojaie, Annabell Coors, Annette L. Fitzpatrick, Claudia Langenberg, Claudia L. Satizabal, Colleen M. Sitlani, Eleanor Wheeler, Elliot M. Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C. Bis, Julián Candia, Lori L. Jennings, Maik Pietzner, Mark Lathrop, Oscar L. Lopez, Paul Redmond, Robert E. Gerszten, Stephen S. Rich, Susan R. Heckbert, Thomas R. Austin, Timothy M. Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S. Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I. Rotter, Keenan A. Walker, Luigi Ferrucci, Mika Kivimäki, Monique M. B. Breteler, Simon R. Cox, Stephanie Debette, Thomas H. Mosley, Vilmundur G. Gudnason, Lenore J. Launer, Bruce M. Psaty, Sudha Seshadri, Myriam Fornage
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We
Externí odkaz:
https://doaj.org/article/8eb6e400abed4b8eba3c10d3a6a5024b
Autor:
William G. Hoffmann, Yan Q. Chen, Charles S. Schwartz, Jacob L. Barber, Prasun K. Dev, Riley J. Reasons, Juan S. Miranda Maravi, Bridget Armstrong, Robert E. Gerszten, Günther Silbernagel, Robert J. Konrad, Claude Bouchard, Mark A. Sarzynski
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100495- (2024)
Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown. We characterized ANGPTL3/8 and
Externí odkaz:
https://doaj.org/article/c80e12bbb63f48e2af9a00413e84aaba
Autor:
Elena V. Feofanova, Michael R. Brown, Taryn Alkis, Astrid M. Manuel, Xihao Li, Usman A. Tahir, Zilin Li, Kevin M. Mendez, Rachel S. Kelly, Qibin Qi, Han Chen, Martin G. Larson, Rozenn N. Lemaitre, Alanna C. Morrison, Charles Grieser, Kari E. Wong, Robert E. Gerszten, Zhongming Zhao, Jessica Lasky-Su, NHLBI Trans-Omics for Precision Medicine (TOPMed), Bing Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of bo
Externí odkaz:
https://doaj.org/article/fd8c3eb176234d4c8fc8bb86a09934a5
Autor:
Jessica A. Regan, Lauren K. Truby, Usman A. Tahir, Daniel H. Katz, Maggie Nguyen, Lydia Coulter Kwee, Shuliang Deng, James G. Wilson, Robert J. Mentz, William E. Kraus, Adrian F. Hernandez, Robert E. Gerszten, Eric D. Peterson, Rury R. Holman, Svati H. Shah
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract There is increasing evidence that HFpEF is a heterogeneous clinical entity and distinct molecular pathways may contribute to pathophysiology. Leveraging unbiased proteomics to identify novel biomarkers, this study seeks to understand the und
Externí odkaz:
https://doaj.org/article/d65338c6427c411a9573c5564d71f7dd
Autor:
Daniel Gonzalez Izundegui, Patricia E. Miller, Ravi V. Shah, Clary B. Clish, Maura E. Walker, Gary F. Mitchell, Robert E. Gerszten, Martin G. Larson, Ramachandran S. Vasan, Matthew Nayor
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-14 (2022)
Abstract Background New biomarkers to identify cardiovascular disease (CVD) risk earlier in its course are needed to enable targeted approaches for primordial prevention. We evaluated whether intraindividual changes in blood metabolites in response t
Externí odkaz:
https://doaj.org/article/fa2a77f62fbc47a9958baa44aa8a585e
Autor:
Jeremy M. Robbins, Robert E. Gerszten
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in car
Externí odkaz:
https://doaj.org/article/1f7ed744be7e40d193d06c09d8044d2a
Autor:
Andrew S. Perry, Shilin Zhao, Venkatesh Murthy, Deepak K. Gupta, William F. Fearon, Juyong B. Kim, Samir Kapadia, Dharam J. Kumbhani, Linda Gillam, Brian Whisenant, Nishath Quader, Alan Zajarias, Ravinder R. Mallugari, Daniel E. Clark, Jay N. Patel, Holly Gonzales, Frederick G. Welt, Anthony A. Bavry, Megan Coylewright, Robert N. Piana, Anna Vatterott, Natalie Jackson, Robert E. Gerszten, Brian R. Lindman, Ravi Shah, Sammy Elmariah
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Background Studies in mice and small patient subsets implicate metabolic dysfunction in cardiac remodeling in aortic stenosis, but no large comprehensive studies of human metabolism in aortic stenosis with long‐term follow‐up and characterization
Externí odkaz:
https://doaj.org/article/1a20f6e37a204a8fa95ea313849c3c4e