Zobrazeno 1 - 10
of 139
pro vyhledávání: '"E, Gascoigne"'
Autor:
Jean-Philippe Fortin, Jenille Tan, Karen E. Gascoigne, Peter M. Haverty, William F. Forrest, Michael R. Costa, Scott E. Martin
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-25 (2019)
Abstract Background Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy
Externí odkaz:
https://doaj.org/article/da41017688c44f37813cd692b3acf27a
Autor:
Ryan Raisner, Samir Kharbanda, Lingyan Jin, Edwin Jeng, Emily Chan, Mark Merchant, Peter M. Haverty, Russell Bainer, Tommy Cheung, David Arnott, E. Megan Flynn, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1722-1729 (2018)
Summary: Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However, the functional impact of this modification at enhancers is poorly understood. Here, we use a chemical genetics approach to acutely block the funct
Externí odkaz:
https://doaj.org/article/30f0b373eb01444dbff75e2a8755acdb
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235343 (2020)
Triple Negative Breast Cancer (TNBC) is a heterogeneous disease lacking known molecular drivers and effective targeted therapies. Cytotoxic chemotherapy remains the mainstay of treatment for TNBCs, which have significantly poorer survival rates compa
Externí odkaz:
https://doaj.org/article/2eb954b511d14a9e8b98f36265b05fcc
Autor:
Denise E. de Almeida Nagata, Eugene Y. Chiang, Suchit Jhunjhunwala, Patrick Caplazi, Vidhyalakshmi Arumugam, Zora Modrusan, Emily Chan, Mark Merchant, Lingyan Jin, David Arnott, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne, Jane L. Grogan
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 269-281.e4 (2019)
Summary: Myeloid-derived suppressor cells (MDSCs) are found in most cancer malignancies and support tumorigenesis by suppressing immunity and promoting tumor growth. Here we identify the bromodomain (BRD) of CBP/EP300 as a critical regulator of H3K27
Externí odkaz:
https://doaj.org/article/59bed4a4121e435abacf7f0ac7ad65fe
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e6d4475a0ae89a8c2dfdd5ab0fdb742
https://doi.org/10.1158/0008-5472.22415367.v1
https://doi.org/10.1158/0008-5472.22415367.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Bromodomain selectivity data for GNE-049 using BROMOscan® panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b2ed65b009a3d6a8d0c6d6fdb82b76
https://doi.org/10.1158/0008-5472.22415364
https://doi.org/10.1158/0008-5472.22415364
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
qPCR analysis of Myc expression after GNE-049 treatment, effects of GNE-049 combination treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348bd12eb407d5287c888e7de21bcfb1
https://doi.org/10.1158/0008-5472.22415379
https://doi.org/10.1158/0008-5472.22415379
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
GNE-049 chemical synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272c8ba9d74f81c9f661d51828b510a5
https://doi.org/10.1158/0008-5472.22415370.v1
https://doi.org/10.1158/0008-5472.22415370.v1
Autor:
Karen E. Gascoigne, Steven Magnuson, F. Anthony Romero, Maureen H. Beresini, Susan Kaufman, Edna Choo, Justin Ly, Zora Modrusan, Peter M. Haverty, Ryan Raisner, Samir Kharbanda, Mark Merchant, Ehud Segal, Cecile de la Cruz, Emily Chan, Jesse Garcia, Lingyan Jin
Resistance invariably develops to antiandrogen therapies used to treat newly diagnosed prostate cancers, but effective treatments for castration-resistant disease remain elusive. Here, we report that the transcriptional coactivator CBP/p300 is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2a174442441346b475aa53f3b8dc698
https://doi.org/10.1158/0008-5472.c.6509253.v1
https://doi.org/10.1158/0008-5472.c.6509253.v1
Autor:
Catherine E Gascoigne
Publikováno v:
Secondary Rules of Primary Importance in International Law ISBN: 0192869019
This chapter examines the way in which current World Trade Organization (WTO) jurisprudence makes determinations regarding causation based on an a priori inferences about the nature of the cause. In particular, this tendency can be seen in the follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8af85374f507ac1950feb6f55f590f97
https://doi.org/10.1093/oso/9780192869012.003.0008
https://doi.org/10.1093/oso/9780192869012.003.0008