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Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 22:53-63
DX-52-1 is a new derivative of a quinocarmycin analogue. The disposition of [3H]-DX-52-1 was investigated in mice and dogs after intravenous administration (4 and 0.15 mg/kg, respectively). The plasma concentration of non-volatile radioactivity was 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7328abf91f569239b6bbf20377bf6544
https://doi.org/10.1007/bf03189785
https://doi.org/10.1007/bf03189785
Publikováno v:
Proceedings of ISSM2000. Ninth International Symposium on Semiconductor Manufacturing (IEEE Cat. No.00CH37130).
Abnormal I/sub DDQ/ (Quiescent V/sub DD/ supply current) indicates the existence of physical damage in a circuit Using this phenomenon, a CAD-based fault diagnosis technology has been developed to analyze the manufacturing yield of logic LSI. This me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c18ed866f31537084ea55e9b4ef76e8
https://doi.org/10.1109/issm.2000.993659
https://doi.org/10.1109/issm.2000.993659
Autor:
E C, Kohn, E, Reed, G A, Sarosy, L, Minasian, K S, Bauer, F, Bostick-Bruton, V, Kulpa, E, Fuse, A, Tompkins, M, Noone, B, Goldspiel, J, Pluda, W D, Figg, L A, Liotta
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(6)
Preclinical and clinical investigation of the combination of the antiangiogenesis/anti-invasion agent carboxyamido-triazole (CAI) administered with the cytotoxic agent paclitaxel (PAX).Colony-forming assays were used to test the activity of CAI plus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49533a657dacaa4ae9c7719414c67d93
https://pubmed.ncbi.nlm.nih.gov/11410496
https://pubmed.ncbi.nlm.nih.gov/11410496
Autor:
K, Yasoshima, T, Kuwabara, E, Fuse, T, Kuramitu, N, Kurata, H, Nishiie, T, Oishi, H, Kobayashi, S, Kobayashi
Publikováno v:
Cancer chemotherapy and pharmacology. 47(2)
To evaluate the metabolic fate of UCN-01, a signal transduction inhibitor, blood and plasma concentrations, distribution, metabolism and excretion were investigated in rats and dogs after intravenous administration of [3H]UCN-01.The radioactivity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be735446f0702d521a4ed975fbb87f64
https://pubmed.ncbi.nlm.nih.gov/11269735
https://pubmed.ncbi.nlm.nih.gov/11269735
Publikováno v:
Pharmaceutical research. 17(5)
The extremely low clearance and small distribution volume of UCN-01 in humans could be partly due to the high degree of binding to hAGP. The quantitative effects of hAGP on the pharmacokinetics of UCN-01 at several levels of hAGP and UCN-01 were esti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::363b37ebed9490f5b379dbd85b2502f8
https://pubmed.ncbi.nlm.nih.gov/10888307
https://pubmed.ncbi.nlm.nih.gov/10888307
Autor:
E, Fuse, H, Tanii, K, Takai, K, Asanome, N, Kurata, H, Kobayashi, T, Kuwabara, S, Kobayashi, Y, Sugiyama
Publikováno v:
Cancer research. 59(5)
The large species difference in the pharmacokinetics/pharmacodynamics of 7-hydroxystaurosporine (UCN-01) can be partially explained by the high affinity binding of UCN-01 to human alpha1-acid glycoprotein (AGP) (Fuse et al, Cancer Res., 58: 3248-3253
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b79e0def8465c228d2fdb26711546e7
https://pubmed.ncbi.nlm.nih.gov/10070963
https://pubmed.ncbi.nlm.nih.gov/10070963
Autor:
E, Fuse, H, Tanii, N, Kurata, H, Kobayashi, Y, Shimada, T, Tamura, Y, Sasaki, Y, Tanigawara, R D, Lush, D, Headlee, W D, Figg, S G, Arbuck, A M, Senderowicz, E A, Sausville, S, Akinaga, T, Kuwabara, S, Kobayashi
Publikováno v:
Cancer research. 58(15)
The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::febaa155dc0416e0cb3ac37428d90688
https://pubmed.ncbi.nlm.nih.gov/9699650
https://pubmed.ncbi.nlm.nih.gov/9699650
Publikováno v:
IGARSS '98. Sensing and Managing the Environment. 1998 IEEE International Geoscience and Remote Sensing. Symposium Proceedings. (Cat. No.98CH36174).
A two-dimensional parabolic wavelet transform was developed in order to concentrate the energy associated with hyperbolic traces typical to subsurface radar images. Since it does not satisfy the orthogonal transform condition, the inverse transform w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb283a8ad8fa6e3802d68c4b4443d818
https://doi.org/10.1109/igarss.1998.703643
https://doi.org/10.1109/igarss.1998.703643
Publikováno v:
Gan to kagaku ryoho. Cancerchemotherapy. 24(8)
The hepatic extraction ratios (EH) of adriamycin (ADR) and mitomycin C (MMC), which were administered clinically by an intra-hepatic arterial route, were measured in rats to clarify the disposition of ADR and MMC in liver. EH values of ADR and MMC we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3cc9246b0e2f6ee119303c54fc927e9
https://pubmed.ncbi.nlm.nih.gov/9212807
https://pubmed.ncbi.nlm.nih.gov/9212807