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Akademický článek

Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion

Autor: Hema M. Swasthi, Joseph L. Basalla, Claire E. Dudley, Anthony G. Vecchiarelli, Matthew R. Chapman

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract Curli are functional amyloids present on the outer membrane of E. coli. CsgF is required for the proper assembly of curli. Here, we found that the CsgF phase separates in vitro and that the ability of CsgF variants to phase-separate is tight

Externí odkaz: https://doaj.org/article/328ff24bca00401994f10e8b4c9ac81d

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Akademický článek

Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes

Autor: Milena Kalaitsidou, Owen R. Moon, Martina Sykorova, Leyuan Bao, Yun Qu, Sujita Sukumaran, Michael Valentine, Xingliang Zhou, Veethika Pandey, Kay Foos, Sergey Medvedev, Daniel J. Powell Jr, Akshata Udyavar, Eric Gschweng, Ruben Rodriguez, Mark E. Dudley, Robert E. Hawkins, Gray Kueberuwa, John S. Bridgeman

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However, extending the clinical benefit to patients with other cancers poses a challenge. Inefficient

Externí odkaz: https://doaj.org/article/7f1e15ebf5834e83a34fa2733d953fd0

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Akademický článek

SNAP- and Halo-tagging and dye introduction protocol for live microscopy in Xenopus embryos

Autor: Claire E. Dudley, Lotte van den Goor, Ann L. Miller

Publikováno v: STAR Protocols, Vol 3, Iss 3, Pp 101622- (2022)

Summary: Traditional fluorescent proteins exhibit limitations in brightness and photostability that hinder optimal characterization of the dynamic cellular behavior of proteins of interest. SNAP- and Halo-tagging are alternatives to traditional fluor

Externí odkaz: https://doaj.org/article/e85b0080e84b4bbbbd861d0bde54e804

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Akademický článek

A new oral testosterone undecanoate therapy comes of age for the treatment of hypogonadal men

Autor: Ronald S. Swerdloff, Robert E. Dudley

Publikováno v: Therapeutic Advances in Urology, Vol 12 (2020)

Background: A novel formulation of oral testosterone undecanoate (TU) was studied in a long- and short-term phase III trial to evaluate safety and efficacy. Methods: Hypogonadal men (age 18–65 years; two morning serum testosterone (T)

Externí odkaz: https://doaj.org/article/9a2bae31cb134e96babe3cb3ad18616b

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Akademický článek

Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response

Autor: Qiong Xue, Emily Bettini, Patrick Paczkowski, Colin Ng, Alaina Kaiser, Timothy McConnell, Olja Kodrasi, Máire F. Quigley, James Heath, Rong Fan, Sean Mackay, Mark E. Dudley, Sadik H. Kassim, Jing Zhou

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)

Abstract Background It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in pati

Externí odkaz: https://doaj.org/article/ad391b0cd0634de0af9c0fb1b8b1b2e4

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Supplementary Figure 1 from Myeloid Cells Obtained from the Blood but Not from the Tumor Can Suppress T-cell Proliferation in Patients with Melanoma

Autor: Steven A. Rosenberg, Mark E. Dudley, Mojgan Ahmadzadeh, John R. Wunderlich, Simon Turcotte, Alena Gros

PDF file, 50K, The relative frequency of leucocytes in melanoma metastasis (n=14) was determined and represented as a percent of all the live cells in the tumor (left panel) and absolute counts/g of tumor (right panel). 'Others' includes tumor cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3627086244cbcfba28fbfb64850e96
https://doi.org/10.1158/1078-0432.22455900

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Data Supplement from Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

Autor: Paul F. Robbins, Steven A. Rosenberg, Yardena Samuels, James C. Yang, Mark E. Dudley, Lindy Davis, Colin Gross, Mona El-Gamil, Yong F. Li, Jessica S. Crystal, Xin Yao, Yong-Chen Lu

Supplementary Fig. S1. Identification of dominant HLA-restriction element. Supplementary Fig. S2. TIL 2591 T cells recognize multiple known antigens. Supplementary Fig. S3. Gene structure of SERPINE2, DUSP12 and SLC24A5. Supplementary Fig. S4. SLC24A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007dcce832b359b21c6d27b273bc2a7a
https://doi.org/10.1158/1078-0432.22454372

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Data from Myeloid Cells Obtained from the Blood but Not from the Tumor Can Suppress T-cell Proliferation in Patients with Melanoma

Autor: Steven A. Rosenberg, Mark E. Dudley, Mojgan Ahmadzadeh, John R. Wunderlich, Simon Turcotte, Alena Gros

Purpose: Myeloid-derived suppressor cells (MDSC) have emerged as an immune-regulatory cell type that is expanded in tumor-bearing mice, but less is known about their immune-suppressive role in patients with cancer.Experimental Design: To study the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436ef6ae2b17af7054489d9094a2f1eb
https://doi.org/10.1158/1078-0432.c.6523152.v1

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