Zobrazeno 1 - 10
of 58
pro vyhledávání: '"E, Christe"'
Autor:
Jillian N. Noblet, Steven P. Moberly, Michael E. Christe, Zachary C. Berwick, Johnathan D. Tune, Hana E. Baker, Eli D. Casalini, Mark C. Kowala, Eugene Zhen, Adam G. Goodwill
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 318:H747-H755
This study tested the hypothesis that (pyr)apelin-13 dose-dependently augments myocardial contractility and coronary blood flow, irrespective of changes in systemic hemodynamics. Acute effects of intravenous (pyr)apelin-13 administration (10 to 1,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d148858c39d6f9f50171ae1104999dbe
https://doi.org/10.1152/ajpheart.00365.2019
https://doi.org/10.1152/ajpheart.00365.2019
Autor:
Liyun Ding, Matthew P. Coghlan, Ellen P.S. Conceição Furber, Jorge Alsina-Fernandez, Kyle W. Sloop, Brian A. Droz, Mridula Dogra, Annie M. Long, Michael E. Christe, Tamer Coskun, Ruth E. Gimeno, Xiaoping Ruan, Jill A. Willency, William C. Roell, Debra L. Konkol, Adrienne K. Holland, Ricardo J. Samms, Jessica L. Friedrich, Libbey S. O’Farrell, Valentina Pirro, Over Cabrera, Daniel A. Briere, Richard Cosgrove, Samantha Wojnicki, Kyla A.L. Collins, Julie S. Moyers, Yanzhu Lin, Christine C. Cheng
Publikováno v:
J Clin Invest
Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered superior glycemic control and weight loss compared with GLP-1R agonism in patients with type 2 diabetes. However, the mechanism by which tirzepatide improves efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4281cb2d7c4426d2de7cba245f46e9
https://doi.org/10.1172/jci146353
https://doi.org/10.1172/jci146353
Autor:
Michael E. Christe
Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme in the synthesis of polyamines, which play a regulatory role in nucleic acid and protein synthesis. The enzyme may be involved in normal and abnormal growth of the myocardium, in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee809bf83353bc3c8ec70111323fff96
https://doi.org/10.23860/thesis-christe-michael-1989
https://doi.org/10.23860/thesis-christe-michael-1989
Autor:
Julie S. Moyers, Ajit Regmi, Ricardo J. Samms, William C. Roell, Michael E. Christe, Xiaoping Ruan
Publikováno v:
Diabetes. 68
Tirzepatide (TZP), a GIP receptor and GLP-1 receptor (GIPR/GLP-1R) dual agonist, has demonstrated profound effects on glycemic control and bodyweight lowering in T2D subjects. However, the mechanism of action for the dual agonism of TZP is incomplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b779e9f7201b9a0ad40a05898b06a2a
https://doi.org/10.2337/db19-1009-p
https://doi.org/10.2337/db19-1009-p
Autor:
Arthur Christopoulos, Patrick M. Sexton, Lachlan Clydesdale, Asuka Inoue, Yi Lynn Liang, Giuseppe Deganutti, Tin T. Truong, Matthew J. Belousoff, Michael E. Christe, Sebastian G.B. Furness, Michael Gregory Bell, Christopher A. Reynolds, Denise Wootten, Kyle W. Sloop, Ming-Wei Wang, Francis S. Willard, Peishen Zhao, Laurence J. Miller, Madeleine M. Fletcher, Radostin Danev
Publikováno v:
Nature. 577(7790)
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, including diabetes and obesity1. Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3281610b7712a853ea43eed24ed0a910
https://pubmed.ncbi.nlm.nih.gov/32297516
https://pubmed.ncbi.nlm.nih.gov/32297516
Autor:
Andrew Ihor Korytko, J. Jacobs, Andrea E Sperry, John Michael Beals, Jessica L. Friedrich, Amy L. Cox, Steven D. Kahl, Eric D. Hawkins, Julie S. Moyers, Hana E. Baker, Ryan John Hansen, Volker Schellenberger, Chen Zhang, Michael E. Christe, M. Dodson Michael, Debra L. Konkol, D. Bruce Baldwin
Publikováno v:
Diabetes. 67
To optimize the action of exogenously administered insulin, we employed XTEN® technology to create insulins with variably sized XTEN amino acid polymers. Recombinant fusions of XTEN polymers linked to insulin lispro with an A21G mutation were prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e51120da1ca78912cf5dabd1af626da
https://doi.org/10.2337/db18-90-lb
https://doi.org/10.2337/db18-90-lb
Autor:
Timothy B. Durham, Jeffrey T. Dixon, James Lee Toth, Angela M. Siesky, Michael E. Christe, Valentine J. Klimkowski, Nathan A. Calvert, John F. Schindler, Dana Sindelar, Kyle W. Sloop, M. Dodson Michael, Jesline T. Alexander-Chacko, Julia X.C. Cao, Ginger Y. Wu, James E. McGee, Rachel N. Cavitt, Stefan Jon Thibodeaux, Sherry Y. Guo, Yong Wang, Michael J. Coghlan, Vladislav V. Kiselyov
Publikováno v:
Journal of Biological Chemistry. 290:20044-20059
Insulin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteolysis of insulin. Recently, a peptide inhibitor of IDE has been shown to affect levels of insulin, amylin, and glucagon in vivo. However, IDE(-/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b79e6dcdb0455d21e4b543d83d06c40
https://doi.org/10.1074/jbc.m115.638205
https://doi.org/10.1074/jbc.m115.638205
Autor:
Guoqing Cao, Patrick I. Eacho, Shuyu Li, James Ficorilli, Michael E. Christe, Angela M. Siesky, Hong Gao, Tonghuan Hu, Laura F. Michael, M. Dodson Michael, Timothy P. Ryan, Patricia S. Foxworthy
Publikováno v:
Endocrinology. 146:5380-5387
Peroxisomes are the exclusive site for the beta-oxidation of very-long-chain fatty acids of more than 20 carbons in length (VLCFAs). Although the bulk of dietary long-chain fatty acids are oxidized in the mitochondria, VLCFAs cannot be catabolized in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08697a9820c55a6a2ab25e883a0e4730
https://doi.org/10.1210/en.2005-0591
https://doi.org/10.1210/en.2005-0591
Autor:
Mary M. Mader, Michael E. Christe, Xushan Wang, Laura J. Bloem, Jeffrey K. Smallwood, Najia Jin, Theodore Goodson, Arindam Chatterjee, Xiaohong Yu, William F. Matter, John E. Toth, Robert M. Campbell, Chris J. Vlahos
Publikováno v:
Journal of Biological Chemistry. 280:19298-19305
Mixed lineage kinase 7 (MLK7) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the pro-apoptotic signaling pathways p38 and JNK. A library of potential kinase inhibitors was screened, and a series of dihydropyrrolopyrazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae4d48cfa570ea18d99988735d7823c
https://doi.org/10.1074/jbc.m413059200
https://doi.org/10.1074/jbc.m413059200
Autor:
Laura F. Michael, James Ficorilli, Keith R. Stayrook, Thomas P. Burris, Michael E. Christe, Todd Cook, Rajesh S. Savkur, Kelli S. Bramlett
Publikováno v:
Endocrinology. 146:984-991
The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that functions as the bile acid receptor. In addition to the critical role FXR plays in bile acid metabolism and transport, it regulates a variety of genes important in lipoprotein m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f332e6af48dfa56d4e0d55f09142d8b
https://doi.org/10.1210/en.2004-0965
https://doi.org/10.1210/en.2004-0965