Zobrazeno 1 - 10
of 209
pro vyhledávání: '"E, Bullen"'
Autor:
Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)
Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those
Externí odkaz:
https://doaj.org/article/255e629500da4e7bab4f1622c9b59485
Autor:
Oliver Looker, Madeline G. Dans, Hayley E. Bullen, Brad E. Sleebs, Brendan S. Crabb, Paul R. Gilson
Publikováno v:
Traffic. 23:442-461
Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f981b5ac5b72d73b0195d0fe45a4081e
https://doi.org/10.1111/tra.12862
https://doi.org/10.1111/tra.12862
Autor:
Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K. Thompson, Alexei A. Kouzmitchev, Hayley E. Bullen, Paul R. Gilson, Alan F. Cowman, Christopher J. Tonkin
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial therapeutics that target the asexual cycle and the symptomatic stage of malaria. Host cell entry is enabled by
Externí odkaz:
https://doaj.org/article/e57a13863f35463ca89cb2fe9e8b1b58
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007670 (2019)
To elicit effective invasion and egress from infected cells, obligate intracellular parasites of the phylum Apicomplexa rely on the timely and spatially controlled exocytosis of specialized secretory organelles termed the micronemes. The effector mol
Externí odkaz:
https://doaj.org/article/840d598b7d5247ea817f67071eebc6c2
Autor:
Dawson B. Ling, William Nguyen, Oliver Looker, Zahra Razook, Kirsty McCann, Alyssa E. Barry, Christian Scheurer, Sergio Wittlin, Hayley E. Bullen, Brendan S. Crabb, Brad E. Sleebs, Paul R. Gilson
With resistance increasing to current antimalarial medicines, there is an urgent need to discover new drug targets and to develop new medicines against these targets. We therefore screened the Open Global Health Library of Merck KGaA, Darmstadt, Germ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79da886bdfa82ef02058e8e17100e95d
https://doi.org/10.1101/2023.04.25.538349
https://doi.org/10.1101/2023.04.25.538349
Autor:
Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir, David T. Riglar, Oliver Looker, Catherine S. Palmer, Betty Kouskousis, Sarah C. Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo‐Anne Chan, Tania F. de Koning‐Ward, Jake Baum, James W. Kazura, James G. Beeson, Alan F. Cowman, Paul R. Gilson, Brendan S. Crabb
Publikováno v:
Molecular Microbiology. 117:1245-1262
Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e333ce452776bb3cf5ddf9a8f4b7c1
https://doi.org/10.1111/mmi.14904
https://doi.org/10.1111/mmi.14904
Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export.
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0204785 (2018)
Malaria parasites remodel their host erythrocytes to gain nutrients and avoid the immune system. Host erythrocytes are modified by hundreds of effector proteins exported from the parasite into the host cell. Protein export is mediated by the PTEX tra
Externí odkaz:
https://doaj.org/article/abed3de29e064a9c802a6cbdd19d71c6
Autor:
Thorey K. Jonsdottir, Brendan Elsworth, Simon Cobbold, Mikha Gabriela, Sarah C. Charnaud, Madeline G. Dans, Molly Parkyn Schneider, Malcolm McConville, Hayley E. Bullen, Brendan S. Crabb, Paul R. Gilson
A key element ofPlasmodiumbiology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ff022b7b4d76b6f7b08f5acf98b01d
https://doi.org/10.1101/2022.11.15.516562
https://doi.org/10.1101/2022.11.15.516562
Autor:
Natalie A Counihan, Scott A Chisholm, Hayley E Bullen, Anubhav Srivastava, Paul R Sanders, Thorey K Jonsdottir, Greta E Weiss, Sreejoyee Ghosh, Brendan S Crabb, Darren J Creek, Paul R Gilson, Tania F de Koning-Ward
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium falciparum parasites, the causative agents of malaria, modify their host erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and for removal of toxic waste. Here we investigate the contribution of the rhop
Externí odkaz:
https://doaj.org/article/97ed3bf0078b4d8eba8c42a7a6284862
Publikováno v:
PeerJ, Vol 5, p e2926 (2017)
Objective The objective was to quantitatively evaluate the validity of ultrasonographic (US) muscle measurements as compared to the gold standard of computed tomography (CT) in the canine. Design This was a prospective study. Population Twenty-five,
Externí odkaz:
https://doaj.org/article/67e30d310faf42c1911e8e30673bce63