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Abstract Background Data from the UK COVID-19 outbreak are emerging, and there are ongoing concerns about a disproportionate effect on ethnic minorities. There is very limited information on COVID-19 in the over-80s, and the rates of hospital-onset i

Externí odkaz: https://doaj.org/article/628310d12c89477c966ee87dfb86efb5

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Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints

Autor: Heleen J. Blussé van Oud-Alblas, Margreke J. E. Brill, Mariska Y. M. Peeters, Dick Tibboel, Meindert Danhof, Catherijne A. J. Knibbe

Publikováno v: BMC Anesthesiology, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background In adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for propofol in adolescents undergoing idiopathic scoliosis surgery with an intra

Externí odkaz: https://doaj.org/article/2e21509f15884249a1bf9c8f16b20547

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Model-Informed Translation of In Vitro Effects of Short-, Prolonged- and Continuous-Infusion Meropenem against Pseudomonas aeruginosa to Clinical Settings

Autor: Iris K. Minichmayr, Suzanne Kappetein, Margreke J. E. Brill, Lena E. Friberg

Publikováno v: Antibiotics, Vol 11, Iss 8, p 1036 (2022)

Pharmacokinetic-pharmacodynamic (PKPD) models have met increasing interest as tools to identify potential efficacious antibiotic dosing regimens in vitro and in vivo. We sought to investigate the impact of diversely shaped clinical pharmacokinetic pr

Externí odkaz: https://doaj.org/article/eef5c854ae064f5e86eb86c08b46286f

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Glycinergic Transmission in the Presence and Absence of Functional GlyT2: Lessons From the Auditory Brainstem

Autor: Sina E. Brill, Ayse Maraslioglu, Catharina Kurz, Florian Kramer, Martin F. Fuhr, Abhyudai Singh, Eckhard Friauf

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 12 (2021)

Synaptic transmission is controlled by re-uptake systems that reduce transmitter concentrations in the synaptic cleft and recycle the transmitter into presynaptic terminals. The re-uptake systems are thought to ensure cytosolic concentrations in the

Externí odkaz: https://doaj.org/article/8fa83ed0cccb43b1ae69c32a7909663e

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Akademický článek

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Periodical

NATHAN E BRILL MD

Publikováno v: Journal of Nervous and Mental Disease; April 1926, Vol. 63 Issue: 4 p429-432, 4p

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