Zobrazeno 1 - 10
of 706
pro vyhledávání: '"E, Baysal"'
Autor:
Melissa Van Norden, Zackary Falls, Sapan Mandloi, Brahm H. Segal, Bora E. Baysal, Ram Samudrala, Peter L. Elkin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Intra-organism biodiversity is thought to arise from epigenetic modification of constituent genes and post-translational modifications of translated proteins. Here, we show that post-transcriptional modifications, like RNA editing, may also
Externí odkaz:
https://doaj.org/article/b55971b1c57b43fbb50a94f454ea9ef3
Autor:
Bora E. Baysal, Abdulrahman A. Alahmari, Tori C. Rodrick, Debra Tabaczynski, Leslie Curtin, Mukund Seshadri, Drew R. Jones, Sandra Sexton
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Increased red cell distribution width (RDW), which measures erythrocyte mean corpuscular volume (MCV) variability (anisocytosis), has been linked to early mortality in many diseases and in older adults through unknown mechanisms. Hypoxic stress has b
Externí odkaz:
https://doaj.org/article/6e386b37317743b7bd8dc77fb128af7f
Autor:
Emad Y. Alqassim, Shraddha Sharma, A. N. M. Nazmul H. Khan, Tiffany R. Emmons, Eduardo Cortes Gomez, Abdulrahman Alahmari, Kelly L. Singel, Jaron Mark, Bruce A. Davidson, A. J. Robert McGray, Qian Liu, Brian D. Lichty, Kirsten B. Moysich, Jianmin Wang, Kunle Odunsi, Brahm H. Segal, Bora E. Baysal
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing i
Externí odkaz:
https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3
Autor:
Shraddha Sharma, Jianmin Wang, Emad Alqassim, Scott Portwood, Eduardo Cortes Gomez, Orla Maguire, Per H. Basse, Eunice S. Wang, Brahm H. Segal, Bora E. Baysal
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs i
Externí odkaz:
https://doaj.org/article/4cb51bbdf793402da1a28e36fd3f9e70
Several adenosine or cytidine deaminase enzymes deaminate transcript sequences in a cell type or environment-dependent manner by a programmed process called RNA editing. RNA editing enzymes catalyze A>I or C>U transcript alterations and have the pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9004d537558b8bd2e9fecc9e8561f453
https://doi.org/10.1158/0008-5472.c.6509271.v1
https://doi.org/10.1158/0008-5472.c.6509271.v1
Levels of global A>I RNA editing in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570254f5ab74e73e4b13db3961b81927
https://doi.org/10.1158/0008-5472.22415400
https://doi.org/10.1158/0008-5472.22415400
Akademický článek
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Akademický článek
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Autor:
Pallawi Torka, Othman S. Akhtar, Nishitha M. Reddy, Bora E. Baysal, Angela Kader, Adrienne Groman, Jenna Nichols, Cory Mavis, Joseph D. Tario, AnneMarie W. Block, Sheila N. J. Sait, Paola Ghione, Suchitra Sundaram, Eugene R. Przespolewski, Alice Mohr, Ian Lund, Jessica Kostrewa, Kenneth McWhite, Joseph DeMarco, Michael Johnson, Andrea Darrall, Rosh‐Neke Thomas‐Talley, Paul K. Wallace, Vishala Neppalli, Alan Hutson, Francisco J. Hernandez‐Ilizaliturri
Publikováno v:
Cancer
BACKGROUND: Ofatumumab is a humanized type 1 anti-CD20 monoclonal antibody. Preclinical studies show improved complement-mediated cytotoxicity (CMC) compared to rituximab in mantle cell lymphoma (MCL). We evaluated the safety and efficacy of combinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1508bb7f430a1d9a2bec787ec4dfb9f
https://doi.org/10.1002/cncr.34106
https://doi.org/10.1002/cncr.34106
Autor:
Shraddha Sharma, Bora E. Baysal
Publikováno v:
PeerJ, Vol 5, p e4136 (2017)
APOBEC3A and APOBEC3G cytidine deaminases inhibit viruses and endogenous retrotransposons. We recently demonstrated the novel cellular C-to-U RNA editing function of APOBEC3A and APOBEC3G. Both enzymes deaminate single-stranded DNAs at multiple TC or
Externí odkaz:
https://doaj.org/article/2d860c8728a44681a40387180a09e836