Guía de recomendaciones en la aplicación de modelos animales para el estudio del ictus

Autor: L. García-Bonilla, A. Rosell, G. Torregrosa, J.B. Salom, E. Alborch, M. Gutiérrez, E. Díez-Tejedor, R. Martínez-Murillo, J. Agulla, P. Ramos-Cabrer, J. Castillo, T. Gasull, J. Montaner

Publikováno v: Neurología, Vol 26, Iss 2, Pp 105-110 (2011)

Resumen: Introducción: La búsqueda de una terapia neuroprotectora efectiva para el ictus sigue siendo un reto para investigadores y clínicos. Una de las causas principales por la que a nivel clínico han fracasado terapias eficaces en ensayos expe

Externí odkaz: https://doaj.org/article/9c4dfdd4ddd94ef7b08ea90c65642920

Delayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke

Autor: O. Hurtado, J.M. Pradillo, D. Fernández-López, J.R. Morales, T. Sobrino, J. Castillo, E. Alborch, M.A. Moro, I. Lizasoain

Publikováno v: Neurobiology of Disease, Vol 29, Iss 1, Pp 123-131 (2008)

Glutamate transport is the only mechanism for maintaining extracellular glutamate concentrations below excitotoxic levels. Among glutamate transporters, EAAT2 is responsible for up to 90% of all glutamate transport and has been reported to be associa

Externí odkaz: https://doaj.org/article/755026848b6e42a2921fbc177a9f06bd

Cerebrovascular Effects of Dotarizine, a Piperazine Derivative, in the Goat

Autor: Juan B. Salom, E Alborch, J M Centeno, M Ortí, M D Barberá, Germán Torregrosa

Publikováno v: Arzneimittelforschung. 49:668-672

The effects of dotarizine (1-(diphenylmethyl)-4-[3-(2-phenyl-1,3- dioxolan-2-yl)propyl]-piperazine, CAS 84625-59-2) on the cerebral circulation of goats were assessed in vivo by recording continuously global cerebral blood flow (gCBF) and cortical pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3129be493b1645b7e7f5f2994a1718a9
https://doi.org/10.1055/s-0031-1300480

Recommendations guide for experimental animal models in stroke research

Autor: M. Gutiérrez, Jesús Agulla, Ricardo Martínez-Murillo, Pedro Ramos-Cabrer, Juan B. Salom, Joan Montaner, José Castillo, E. Alborch, T. Gasull, Lidia Garcia-Bonilla, Anna Rosell, Exuperio Díez-Tejedor, Germán Torregrosa

Publikováno v: NEUROLOGIA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Neurología (English Edition), Vol 26, Iss 2, Pp 105-110 (2011)

Introduction: The progress of effective therapies for stroke has become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might have their origins in the pre-clinical experimental ischaemic models for the evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ab8714114844c32955160afd7a9a34

Cerebrovascular effects of dotarizine, a piperazine derivative, in the goat. An in vivo and in vitro complementary study

Autor: G, Torregrosa, M D, Barberá, M, Ortí, J M, Centeno, J B, Salom, E, Alborch

Publikováno v: Arzneimittel-Forschung. 49(8)

The effects of dotarizine (1-(diphenylmethyl)-4-[3-(2-phenyl-1,3- dioxolan-2-yl)propyl]-piperazine, CAS 84625-59-2) on the cerebral circulation of goats were assessed in vivo by recording continuously global cerebral blood flow (gCBF) and cortical pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28de04d8e34f437597446f4f86b22f11
https://pubmed.ncbi.nlm.nih.gov/10483512