Zobrazeno 1 - 10
of 134
pro vyhledávání: '"E, Acton"'
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
Upon initial immune challenge, dendritic cells (DCs) migrate to lymph nodes and interact with fibroblastic reticular cells (FRCs) via C-type lectin-like receptor 2 (CLEC-2). CLEC-2 binds to the membrane glycoprotein podoplanin (PDPN) on FRCs, inhibit
Externí odkaz:
https://doaj.org/article/ed468f6c1388465daedb3726df30ee90
Autor:
Jing Zhao, Sungwook Jung, Xiaofei Li, Lushen Li, Vivek Kasinath, Hengcheng Zhang, Said N. Movahedi, Ahmad Mardini, Gianmarco Sabiu, Yoonha Hwang, Vikas Saxena, Yang Song, Bing Ma, Sophie E. Acton, Pilhan Kim, Joren C. Madsen, Peter T. Sage, Stefan G. Tullius, George C. Tsokos, Jonathan S. Bromberg, Reza Abdi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of heart transpla
Externí odkaz:
https://doaj.org/article/bc8427fba19b4be3b7fbe037cc02ca92
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The tumour microenvironment (TME) presents a major block to anti-tumour immune responses and to effective cancer immunotherapy. The inflammatory mediators such as cytokines, chemokines, growth factors and prostaglandins generated in the TME alter the
Externí odkaz:
https://doaj.org/article/e73fac2e64be48678ef36b2b4853e467
Autor:
Spyridon Makris, Charlotte M. de Winde, Harry L. Horsnell, Jesús A. Cantoral-Rebordinos, Rachel E. Finlay, Sophie E. Acton
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular interactions wi
Externí odkaz:
https://doaj.org/article/67305cf3e9c7440783749926d16539cb
Autor:
Charlotte M. de Winde, Samantha L. George, Eva Crosas-Molist, Yukti Hari-Gupta, Abbey B. Arp, Agnesska C. Benjamin, Lindsey J. Millward, Spyridon Makris, Alexander Carver, Valerio Imperatore, Víctor G. Martínez, Victoria Sanz-Moreno, Sophie E. Acton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102976- (2021)
Summary: Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology
Externí odkaz:
https://doaj.org/article/4ccbb9bd840641f084f5a6f000008701
Autor:
Lukas Krasny, Philip Bland, Jessica Burns, Nadia Carvalho Lima, Peter T. Harrison, Laura Pacini, Mark L. Elms, Jian Ning, Victor Garcia Martinez, Yi-Ru Yu, Sophie E. Acton, Ping-Chih Ho, Fernando Calvo, Amanda Swain, Beatrice A. Howard, Rachael C. Natrajan, Paul H. Huang
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that permits quantification of up to
Externí odkaz:
https://doaj.org/article/b6c53000988f46049f04a777ee5ad346
Autor:
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2810-2822.e5 (2019)
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs under
Externí odkaz:
https://doaj.org/article/4fe1b76aeb144cf7aa575df20599c264
Publikováno v:
eLife, Vol 8 (2019)
The challenges facing a new independent group leader, principal investigator (PI) or university lecturer are formidable: secure funding, recruit staff and students, establish a research programme, give lectures, and carry out various administrative d
Externí odkaz:
https://doaj.org/article/1ea35103158b4e1b8dc332ca69a21495
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