Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dzmitry G. Batrakou"'
Autor:
Rafal Czapiewski, Dzmitry G. Batrakou, Jose I. de las Heras, Roderick N. Carter, Aishwarya Sivakumar, Magdalena Sliwinska, Charles R. Dixon, Shaun Webb, Giovanna Lattanzi, Nicholas M. Morton, Eric C. Schirmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Little is known how spatial genome organization is directed in fat; however, key proadipogenic genes reposition from the nuclear envelope (NE) to the interior during adipogenesis. Here the authors show that deletion of NE protein Tmem120a in adipocyt
Externí odkaz:
https://doaj.org/article/5efba97324ba4758897fa78e06687621
Autor:
David S. Hong, Marcus O. Butler, Russell K. Pachynski, Ryan Sullivan, Partow Kebriaei, Sarah Boross-Harmer, Armin Ghobadi, Matthew J. Frigault, Ecaterina E. Dumbrava, Amy Sauer, Francine Brophy, Jean-Marc Navenot, Svetlana Fayngerts, Zohar Wolchinsky, Robyn Broad, Dzmitry G. Batrakou, Ruoxi Wang, Luisa M. Solis, Dzifa Yawa Duose, Joseph P. Sanderson, Andrew B. Gerry, Diane Marks, Jane Bai, Elliot Norry, Paula M. Fracasso
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T-cells are genetically engineered autologous T-cells that express a high-affinity melanoma-associated antigen (MAGE)-A10-specific T-cell receptor (TCR) targeting MAGE-A10-positi
Externí odkaz:
https://doaj.org/article/4c808abbb2f84a2ab7ad3e5e7de8a030
Autor:
David S. Hong, Brian A. Van Tine, Swethajit Biswas, Cheryl McAlpine, Melissa L. Johnson, Anthony J. Olszanski, Jeffrey M. Clarke, Dejka Araujo, George R. Blumenschein, Partow Kebriaei, Quan Lin, Alex J. Tipping, Joseph P. Sanderson, Ruoxi Wang, Trupti Trivedi, Thejo Annareddy, Jane Bai, Stavros Rafail, Amy Sun, Lilliam Fernandes, Jean-Marc Navenot, Frederic D. Bushman, John K. Everett, Derin Karadeniz, Robyn Broad, Martin Isabelle, Revashnee Naidoo, Natalie Bath, Gareth Betts, Zohar Wolchinsky, Dzmitry G. Batrakou, Erin Van Winkle, Erica Elefant, Armin Ghobadi, Amanda Cashen, Anne Grand’Maison, Philip McCarthy, Paula M. Fracasso, Elliot Norry, Dennis Williams, Mihaela Druta, David A. Liebner, Kunle Odunsi, Marcus O. Butler
Publikováno v:
Nature Medicine. 29:104-114
Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy. Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell therapy targeting melanoma-associated antigen A4 (MAGE-A4), a cance
Autor:
Sheila Webb, de las Heras Ji, Rafal Czapiewski, Giovanna Lattanzi, Dzmitry G. Batrakou, Charles R. Dixon, Eric C. Schirmer, Nik M. Morton, Sliwinska M, Aishwarya Sivakumar, Carter Rn
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Czapiewski, R, Batrakou, D G, de las Heras, J, Nicholas Carter, R, Sivakumar, A, Sliwinska, M, Dixon, C, Webb, S, Lattanzi, G, Morton, N M & Schirmer, E C 2022, ' Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy ', Nature Communications, vol. 13, no. 1, 321 . https://doi.org/10.1038/s41467-021-27869-2
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Czapiewski, R, Batrakou, D G, de las Heras, J, Nicholas Carter, R, Sivakumar, A, Sliwinska, M, Dixon, C, Webb, S, Lattanzi, G, Morton, N M & Schirmer, E C 2022, ' Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy ', Nature Communications, vol. 13, no. 1, 321 . https://doi.org/10.1038/s41467-021-27869-2
Little is known about how the observed fat-specific pattern of 3D-spatial genome organisation is established. Here we report that adipocyte-specific knockout of the gene encoding nuclear envelope transmembrane protein Tmem120a disrupts fat genome org
Autor:
Nhan T. Pham, Sarah Zheng, Nikolaj Zuleger, Andrea Rizzotto, Eric C. Schirmer, Manfred Auer, Mike Tyers, Valerie G. Brunton, Jan Lammerding, Jeremy Keys, Neil O. Carragher, Sylvain Tollis, Dzmitry G. Batrakou, Jayne Culley, Jan Wildenhain
Lower survival rates for many cancer types correlate with increases or decreases in nuclear size/scaling in a tumor-type/tissue-specific manner. Postulating that nuclear size changes confer a fitness advantage on tumor cells, we screened for FDA/EMA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7369775b9e92d9011ba0a366cfb96f94
Publikováno v:
Nature protocols. 15(3)
Genome replication follows a defined temporal programme that can change during cellular differentiation and disease onset. DNA replication results in an increase in DNA copy number that can be measured by high-throughput sequencing. Here we present a
Autor:
Jose I, de Las Heras, Nikolaj, Zuleger, Dzmitry G, Batrakou, Rafal, Czapiewski, Alastair R W, Kerr, Eric C, Schirmer
Publikováno v:
Nucleus
Different cell types exhibit distinct patterns of 3D genome organization that correlate with changes in gene expression in tissue and differentiation systems. Several tissue-specific nuclear envelope transmembrane proteins (NETs) have been found to i
Publikováno v:
de Las Heras, J I, Batrakou, D G & Schirmer, E C 2012, ' Cancer biology and the nuclear envelope: A convoluted relationship ', seminars in cancer biology . https://doi.org/10.1016/j.semcancer.2012.01.008
Although its properties have long been used for both typing and prognosis of various tumors, the nuclear envelope (NE) itself and its potential roles in tumorigenesis are only beginning to be understood. Historically viewed as merely a protective bar
Autor:
Nikolaj Zuleger, Nadia Korfali, Jose I. de las Heras, Eric C. Schirmer, Laurence Florens, Poonam Malik, Vlastimil Srsen, Selene K. Swanson, Gavin S. Wilkie, Alastair R.W. Kerr, Dzmitry G. Batrakou
Publikováno v:
Korfali, N, Wilkie, G S, Swanson, S K, Srsen, V, de las Heras, J, Batrakou, D G, Malik, P, Zuleger, N, Kerr, A, Florens, L & Schirmer, E 2012, ' The nuclear envelope proteome differs notably between tissues ', Nucleus, vol. 3, no. 6, pp. 552-564 . https://doi.org/10.4161/nucl.22257
Nucleus
Nucleus
One hypothesis to explain how mutations in the same nuclear envelope proteins yield pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners mediate the disease pathologies. The nuclear envelope proteome was recent
Publikováno v:
Nucleic Acids Research
Genomes are replicated in a reproducible temporal pattern. Current methods for assaying allele replication timing are time consuming and/or expensive. These include high-throughput sequencing which can be used to measure DNA copy number as a proxy fo