Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dzjemma Sarkisjan"'
Autor:
Anne Dirkse, Anna Golebiewska, Thomas Buder, Petr V. Nazarov, Arnaud Muller, Suresh Poovathingal, Nicolaas H. C. Brons, Sonia Leite, Nicolas Sauvageot, Dzjemma Sarkisjan, Mathieu Seyfrid, Sabrina Fritah, Daniel Stieber, Alessandro Michelucci, Frank Hertel, Christel Herold-Mende, Francisco Azuaje, Alexander Skupin, Rolf Bjerkvig, Andreas Deutsch, Anja Voss-Böhme, Simone P. Niclou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by mo
Externí odkaz:
https://doaj.org/article/f9953d80d7214efbbab8832d2c810d81
The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.
Autor:
Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg, Rutger Meinsma, Young B Lee, Deog J Kim, Godefridus J Peters
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162901 (2016)
Fluorocyclopentenylcytosine (RX-3117) is an orally available cytidine analog, currently in Phase I clinical trial. RX-3117 has promising antitumor activity in various human tumor xenografts including gemcitabine resistant tumors. RX-3117 is activated
Externí odkaz:
https://doaj.org/article/ecd36541f4fd43e4b410765524e870bd
Autor:
Dzjemma Sarkisjan, Godefridus J. Peters, Btissame El Hassouni, Elisa Giovannetti, J. Chris Vos
Publikováno v:
Current Medicinal Chemistry, 26(33), 6020-6032. Bentham Science Publishers B.V.
El Hassouni, B, Sarkisjan, D, Vos, J C, Giovannetti, E & Peters, G J 2019, ' Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance ', Current Medicinal Chemistry, vol. 26, no. 33, pp. 6020-6032 . https://doi.org/10.2174/0929867326666181203133332
el Hassouni, B, Sarkisjan, D, Vos, J C, Giovannetti, E & Peters, G J 2019, ' Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance ', Current Medicinal Chemistry, vol. 26, no. 33, pp. 6020-6032 . https://doi.org/10.2174/0929867326666181203133332
El Hassouni, B, Sarkisjan, D, Vos, J C, Giovannetti, E & Peters, G J 2019, ' Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance ', Current Medicinal Chemistry, vol. 26, no. 33, pp. 6020-6032 . https://doi.org/10.2174/0929867326666181203133332
el Hassouni, B, Sarkisjan, D, Vos, J C, Giovannetti, E & Peters, G J 2019, ' Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance ', Current Medicinal Chemistry, vol. 26, no. 33, pp. 6020-6032 . https://doi.org/10.2174/0929867326666181203133332
Background: Inherent or acquired chemo resistance in cancer patients has been a perpetual limitation in cancer treatment. Expanding knowledge on essential cellular processes opens a new window for therapeutic targeting. Ribosome biogenesis is a proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335e0057ead0c054745376eaf40bddfa
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076281885&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076281885&origin=inward
Autor:
Larry H. Matherly, Young Bok Lee, Joris R. Julsing, Dzjemma Sarkisjan, Btissame El Hassouni, Godefridus J. Peters, Deog Joong Kim, Ietje Kathmann, Richard J. Honeywell
Publikováno v:
Sarkisjan, D, Julsing, J R, El Hassouni, B, Honeywell, R J, Kathmann, I, Matherly, L H, Lee, Y B, Kim, D J & Peters, G J 2020, ' Rx-3117 (Fluorocyclopentenyl-cytosine)-mediated down-regulation of dna methyltransferase 1 leads to protein expression of tumor-suppressor genes and increased functionality of the proton-coupled folate carrier ', International Journal of Molecular Sciences, vol. 21, no. 8, 2717 . https://doi.org/10.3390/ijms21082717
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, 21(8):2717. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2717, p 2717 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences, 21(8):2717. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2717, p 2717 (2020)
(1) Background: RX-3117 (fluorocyclopentenyl-cytosine) is a cytidine analog that inhibits DNA methyltransferase 1 (DNMT1). We investigated the mechanism and potential of RX-3117 as a demethylating agent in several in vitro models. (2) Methods: we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0b844558a3fc411cacfcb3190c8d10
https://research.vumc.nl/en/publications/038cd18b-dcaa-4848-94b5-1a8098b9efcb
https://research.vumc.nl/en/publications/038cd18b-dcaa-4848-94b5-1a8098b9efcb
Autor:
Sonia Leite, Christel Herold-Mende, Anna Dirkse, Dzjemma Sarkisjan, Daniel Stieber, Nicolaas H. C. Brons, Sabrina Fritah, Thomas Buder, Rolf Bjerkvig, Anja Voss-Böhme, Francisco Azuaje, Andreas Deutsch, Simone P. Niclou, Nicolas Sauvageot, Frank Hertel, Alesandro Michelucci, Mathieu Seyfrid, Petr V. Nazarov, Anna Golebiewska, Alexander Skupin, Suresh Poovathingal, Arnaud Muller
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Dirkse, A, Golebiewska, A, Buder, T, Nazarov, P V, Muller, A, Poovathingal, S, Brons, N H C, Leite, S, Sauvageot, N, Sarkisjan, D, Seyfrid, M, Fritah, S, Stieber, D, Michelucci, A, Hertel, F, Herold-Mende, C, Azuaje, F, Skupin, A, Bjerkvig, R, Deutsch, A, Voss-Böhme, A & Niclou, S P 2019, ' Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment ', Nature Communications, vol. 10, no. 1, 1787 . https://doi.org/10.1038/s41467-019-09853-z
Nature Communications, 10(1):1787. Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Dirkse, A, Golebiewska, A, Buder, T, Nazarov, P V, Muller, A, Poovathingal, S, Brons, N H C, Leite, S, Sauvageot, N, Sarkisjan, D, Seyfrid, M, Fritah, S, Stieber, D, Michelucci, A, Hertel, F, Herold-Mende, C, Azuaje, F, Skupin, A, Bjerkvig, R, Deutsch, A, Voss-Böhme, A & Niclou, S P 2019, ' Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment ', Nature Communications, vol. 10, no. 1, 1787 . https://doi.org/10.1038/s41467-019-09853-z
Nature Communications, 10(1):1787. Nature Publishing Group
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and resistance have been challenged in brain tumors. Here we report that cells expressing CSC-associated cell membrane markers in Glioblastoma (GBM) do not represent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41916d135cd4cd09182249c39df34022
https://hdl.handle.net/1956/22507
https://hdl.handle.net/1956/22507
Autor:
Godefridus J. Peters, Richard J. Honeywell, Michael H. Kristensen, Daniel de Klerk, Dzjemma Sarkisjan
Publikováno v:
Honeywell, R J, Sarkisjan, D, Kristensen, M H, de Klerk, D J & Peters, G J 2018, ' DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors. ', Nucleosides, Nucleotides and Nucleic Acids, vol. 37, no. 12, pp. 696-708 . https://doi.org/10.1080/15257770.2018.1498516
Nucleosides, Nucleotides and Nucleic Acids, 37(12), 696-708. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 37(12), 696-708. Taylor and Francis Ltd.
DNA methylation plays an important role in carcinogenesis and aberrant methylation patterns have been found in many tumors. Methylation is regulated by DNA methyltransferases (DNMT), catalyzing DNA methylation. Therefore inhibition of DNMT is an inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639830099c5b79aa9e6b2e6ee8d53807
https://pubmed.ncbi.nlm.nih.gov/30663502
https://pubmed.ncbi.nlm.nih.gov/30663502
Publikováno v:
Sarkisjan, D, Steenbergen, R D M, Cloos, J & Peters, G J 2017, Re-emerging antimetabolites with novel mechanism of action with respect to epigenetic regulation : Basic aspects . in Chemotherapy for Leukemia : Novel Drugs and Treatment . Springer Singapore, pp. 311-326 . https://doi.org/10.1007/978-981-10-3332-2_18
Chemotherapy for Leukemia: Novel Drugs and Treatment, 311-326
STARTPAGE=311;ENDPAGE=326;TITLE=Chemotherapy for Leukemia
Chemotherapy for Leukemia ISBN: 9789811033308
Chemotherapy for Leukemia: Novel Drugs and Treatment, 311-326
STARTPAGE=311;ENDPAGE=326;TITLE=Chemotherapy for Leukemia
Chemotherapy for Leukemia ISBN: 9789811033308
Azacitidine (AzaC) and decitabine (DAC) are epigenetic modulators, which are used for treatment of several hematological malignancies. The epigenetic mode of action of these compounds comprises reduction of DNA methylation by inhibition of DNA methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e223094ea9a32137bb162d9684b277
https://research.vumc.nl/en/publications/2f075086-bfc1-4d2f-9899-46c92344f5c2
https://research.vumc.nl/en/publications/2f075086-bfc1-4d2f-9899-46c92344f5c2
Autor:
Godefridus J. Peters, Michael H. Kristensen, Richard J. Honeywell, Dzjemma Sarkisjan, Ietje Kathmann
Publikováno v:
Honeywell, R J, Sarkisjan, D, Kathmann, I, Kristensen, M H & Peters, G J 2016, ' Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA ', Nucleosides, Nucleotides and Nucleic Acids, vol. 35, no. 10-12, pp. 652-662 . https://doi.org/10.1080/15257770.2016.1216566
Nucleosides, Nucleotides and Nucleic Acids, 35(10-12), 652-662. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 35(10-12), 652-662. Taylor and Francis Ltd.
Antimetabolites are incorporated into DNA and RNA, affecting their function. Liquid-chromatography-mass-spectrometry (LC-MS-MS) permits the sensitive, selective analysis of normal nucleosides. The method was adapted to measure the incorporation of de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eefe87860d75fe47aa97fc9f97ef451
https://pubmed.ncbi.nlm.nih.gov/27906622
https://pubmed.ncbi.nlm.nih.gov/27906622
Autor:
Elisa Giovannetti, Young Bok Lee, Godefridus J. Peters, Daniel J. De Klerk, Dzjemma Sarkisjan, Kees Smid, Deog Joong Kim, Btissame El Hassouni, Joris R. Julsing, Safet Zekanovic, Richard J. Honeywell, Beatrice Balboni
Publikováno v:
Cancer Research. 79:1267-1267
RX-3117 is a novel cytidine analog showing encouraging results in ongoing Phase 2a studies with gemcitabine-resistant pancreatic ductal adenocarcinoma and advanced urothelial bladder cancer. Cellular uptake of RX-3117 is mediated by the equilibrative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0216442f614b1622fcd3bee87f0949f
https://doi.org/10.1158/1538-7445.am2019-1267
https://doi.org/10.1158/1538-7445.am2019-1267
Autor:
Deog Joong Kim, Ietje Kathmann, Young Bok Lee, Chang-Ho Ahn, Godefridus J. Peters, Aric Orbach, Leonardo Vecchi, Nienke Losekoot, Kees Smid, Richard J. Honeywell, Eran Blaugrund, Osnat Ohne, Lak Shin Jeong, Dzjemma Sarkisjan
Publikováno v:
Peters, G J, Smid, K, Vecchi, L, Kathmann, I, Sarkisjan, D, Honeywell, R J, Losekoot, N, Ohne, O, Orbach, A, Blaugrund, E, Jeong, L S, Lee, Y B, Ahn, C H & Kim, D J 2013, ' Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360) ', Investigational New Drugs, vol. 31, no. 6, pp. 1444-1457 . https://doi.org/10.1007/s10637-013-0025-x
Investigational New Drugs, 31(6), 1444-1457. Kluwer Academic Publishers
Investigational New Drugs, 31(6), 1444-1457. Kluwer Academic Publishers
A novel cytidine analog fluorocyclopentenylcytosine (RX-3117; TV-1360) was characterized for its cytotoxicity in a 59-cell line panel and further characterized for cytotoxicity, metabolism and mechanism of action in 15 additional cancer cell lines, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6007e50d218b698c53464fa972777893
https://doi.org/10.1007/s10637-013-0025-x
https://doi.org/10.1007/s10637-013-0025-x