Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Dysmyelopoietic Syndromes"'
Autor:
Catherine Luedke, Pu Su, Sarah Rapisardo, Chuanyi M. Lu, Abner Louissaint, Endi Wang, Chad M. McCall, Bethany Dawn Vallangeon, Lian-He Yang
Publikováno v:
American Journal of Clinical Pathology. 150:246-258
Objectives Therapy-related chronic myeloid leukemia (CML) has been reported, but its clinical presentation and pathologic features have not yet been well characterized. Methods Twenty-one cases of CML following treatment for primary diseases were col
Autor:
Ali Gabali, Jay Yang
Publikováno v:
Blood. 133(20)
[Figure][1] A 65-year-old woman was diagnosed with myelodysplastic syndrome (MDS) with extra blasts-2 with 10% myeloblasts without any evidence of a mast cell disorder. She received azacitidine without response. Thirteen months after the initial diag
Autor:
Tomas Radivoyevitch, Hirohito Shima, Marcin W. Wlodarski, Hassan Awada, Samuel Li, Yasunobu Nagata, Teodora Kuzmanovic, Kenichi Yoshida, Bartlomiej P Przychodzen, Cassandra M. Hirsch, Babal K. Jha, Victor B Pastor, Rabi Hanna, Jaroslaw P. Maciejewski, Vera Adema, Thomas LaFramboise, Satoshi Narumi, Yihong Guan, Jörg Cammenga, Hideki Makishima, Mikkael A. Sekeres, Seishi Ogawa, Francesc Solé, Mai Aly
TO THE EDITOR: Familial bone marrow failure (BMF) syndromes present typically in children and younger adults.[1][1][⇓][2]-[3][3] A number of germline (GL) mutations in genes such as DDX41 ,[4][4] RUNX1 ,[5][5] ETV6 ,[6][6] GATA2 ,[7][7] and ANKRD26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dac5dc41db977ba67b69c2ab07074f
https://europepmc.org/articles/PMC6251008/
https://europepmc.org/articles/PMC6251008/
Autor:
Hagop M. Kantarjian, Katherine Walsh, Guillermo Garcia-Manero, Scott D. Lunin, Casey O'Connell, Gail J. Roboz, Wendy Stock, Michael R. Savona, Nikolai A. Podoltsev, Todd L. Rosenblat, Karen W.L. Yee, Xiang Yao Su, Elizabeth A. Griffiths, Elias Jabbour, Jean Pierre J. Issa, Mohammad Azab, Raoul Tibes
Publikováno v:
Blood. 134:2957-2957
Background: Guadecitabine is a next generation subcutaneous (SC) hypomethylating agent (HMA) resistant to degradation by cytidine deaminase which results in prolonged in vivo exposure to the active metabolite decitabine. We conducted a phase 2 study
Autor:
Karen W.L. Yee, Alexandre Mamedov, Brian Leber, Nancy Zhu, April Shamy, Eve St-Hilaire, Heather A. Leitch, Versha Banerji, Grace Christou, Mitchell Sabloff, Lisa Chodirker, Mohamed Elemary, Richard A. Wells, Michelle Geddes, Robert Delage, Aksharh Kirubananthaan, Mary-Margaret Keating, Rena Buckstein, Liying Zhang, John M. Storring, Nicholas Finn, Thomas J. Nevill
Publikováno v:
Blood. 134:5416-5416
Background: More than 50% of patients with myelodysplastic syndrome (MDS) become transfusion dependent (TD) during the course of their disease and 25-30% present as TD at diagnosis. While TD is more common in IPSS/IPSS-R higher risk patients and is a
Autor:
Max Levine, Julie Schanz, Senji Kasahara, Donna Neuberg, Kamal Menghrajani, Luca Malcovati, Robert P. Hasserjian, Yasushi Miyazaki, Felicitas Thol, Tetsuichi Yoshizato, Catherine Cargo, Jacqueline Boultwood, Takayuki Ishikawa, Olivier Kosmider, Monika Belickova, Hisashi Tsurumi, Sean M. Devlin, Uwe Platzbecker, Ronald Feitosa Pinheiro, Matteo G. Della Porta, Shigeru Chiba, Kristen E. Stevenson, Maria Creignou, Michael Heuser, Chantana Polprasert, Mario Cazzola, Martin Jädersten, Agnes Viale, Michael R. Savona, Arjan A. van de Loosdrecht, Toru Kiguchi, Yasuhito Nannya, Pierre Fenaux, Eva Hellstrom Lindberg, Christina Ganster, Norbert Gattermann, Yusuke Shiozawa, Fabio Ps Santos, Benjamin L. Ebert, Peter Valent, Magnus Tobiasson, Carlo Finelli, Akifumi Takaori-Kondo, Juan E. Arango Ossa, Elli Papaemmanuil, Detlef Haase, Elsa Bernard, Katelynd Vanness, Matilde Y. Follo, Francesc Solé, Araxe Sarian, Michaela Fontenay, Ulrich Germing, Joop H. Jansen, Peter L. Greenberg, Virginia M. Klimek, Yanming Zhang, Kelly L. Bolton, Ioannis Kotsianidis, Seishi Ogawa, Maria Teresa Voso, Minal Patel, Alexandra Smith, Rafael Bejar, José Cervera, Yoshiko Atsuta, Valeria Santini, Yesenia Werner, Juan Medina, Andrea Pellagatti, John M. Bennett, Lee-Yung Shih, Lionel Ades, Ryunosuke Saiki, Heinz Tuechler
Publikováno v:
Blood. 134:675-675
Background In patients with Myelodysplastic Syndromes (MDS), TP53 mutations associate with high-risk presentation, complex karyotype, acute myeloid leukemia (AML) progression and poor response to hematopoietic stem cell transplantation. These associa
Publikováno v:
Blood. 134:3407-3407
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, life-threatening blood disease. While PNH is known to be a rare disease, the incidence and prevalence of the condition has been described only in a few small studies. In addition
Autor:
David Young, Guillermo Garcia-Manero, Ehab Atallah, Shyamala C. Navada, Afoluso Ronnee Adesanya, Elizabeth A. Griffiths, Rosalie Odchimar-Reissig, Pierre Fenaux, Jamile M. Shammo, Richard C. Woodman, Shaker R. Dakhil, Patrick S. Zbyszewski, M. Nabeel Rajeh, Samer K. Khaled, Lewis R. Silverman
Publikováno v:
Blood. 134:566-566
Background: AZA monotherapy has demonstrated improvement in OS in HR MDS, clinically meaningful and durable responses continue to be limited to a subset of patients (Silverman 2006). One obvious strategy is to develop doublet therapy with drugs that
Autor:
Ryan J. Golden, Agata M. Bogusz
Publikováno v:
Blood. 133:2624-2624
[Figure][1] A 29-year-old man without significant medical history was evaluated for fatigue and persistent mild thrombocytopenia spanning >5 years. His complete blood count revealed hemoglobin of 14.3 g/dL, mean corpuscular volume of 88 fL, white blo
Autor:
Alison Edinger, Ebenezer S. Osei, Karen Schweitzer, Howard J. Meyerson, Anna Balog, Georgetta Blidaru
Publikováno v:
American Journal of Clinical Pathology. 140:658-669
Objectives: To determine whether the fraction of CD177+ neutrophils might be altered in clonal myeloid disorders, similar to the skewed κ/λ ratio for B-cell lymphomas, and could be used to identify myeloid neoplasms. Methods: Blood and bone marrow