Výsledky vyhledávání - "Dylan T. Jones"

Akademický článek

Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice

Autor: Dylan T. Jones, Tanguy Lechertier, Louise E. Reynolds, Richard Mitter, Stephen D. Robinson, Catherine B. Kirn-Safran, Kairbaan M. Hodivala-Dilke

Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 1, Pp 115-124 (2013)

SUMMARY Cellular ribosomal protein L29 (RPL29) is known to be important in protein synthesis, but its function during angiogenesis has never been described before. We have shown previously that mice lacking β3-integrins support enhanced tumour angio

Externí odkaz: https://doaj.org/article/bcdc0562099e4d4baa6877853fc23d6f

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Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Autor: Adrian L. Harris, Michael J.O. Wakelam, Eyal Gottlieb, Almut Schulze, Susan E. Critchlow, Eric O. Aboagye, Barrie Peck, Zachary T. Schug, Elizabeth A. Smethurst, Qifeng Zhang, Syed Haider, Alessandro Valli, Dylan T. Jones

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. FASN and B. DGAT inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296bb68cd5c019936a1ef3f8f3f2c884
https://doi.org/10.1158/1535-7163.22508365

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Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60daf610bff0e2bf95b43c86f86c0cb4
https://doi.org/10.1158/1535-7163.22508368.v1

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Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. ACC and B. PDHK inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc03940dab83b7d2ca0a563a7288b02
https://doi.org/10.1158/1535-7163.22508362.v1

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Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

GI50 calculation of spheroids treated with inhibitors. (A) MDA-MB-468 on day 8 and (B) PC3 spheroids on day 12 treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Between 5 and 15 sph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7333ce6954bf5cbb452d5e1691c771
https://doi.org/10.1158/1535-7163.22508371

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Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Two dimensional CyQuant cell proliferation assay of (A) MDA-MB-468 and (B) PC3 cells following 3 days of treatment under normoxic and hypoxic conditions with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bde0d00b5065de6ca244068f1993d0
https://doi.org/10.1158/1535-7163.22508374

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Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Significant differential abundance analysis of lipids as a heat map. A. MDA-MB-468 and B. PC3 spheroids were treated for 4 days with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and kinases PI3K, AKT and mTOR at two different concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6962d0b31b1aaae8cc611b54bcbe6fac
https://doi.org/10.1158/1535-7163.22508359.v1

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Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

Analysis of saturated, mono-unsaturated and poly-unsaturated phospholipids in MDA-MB-468 and PC3 spheroids. Levels of PC, PE, PI, PS, and SM in MDA-MB-468 and PC3 spheroids treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c1171c50c5fcc5af645d51f686fd61
https://doi.org/10.1158/1535-7163.22508356

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Expression Profile of Myoepithelial Cells in DCIS: Do They Change From Protective Angels to Wicked Witches?

Autor: Marwa M, Dawoud, Dylan T, Jones, Claude, Chelala, Asmaa G, Abdou, Sally A, Dreger, Nancy, Asaad, Moshirah, Abd El-Wahed, Louise, Jones

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 30:397-409

The mechanism of transition of ductal carcinoma in situ (DCIS) to invasive cancer is elusive but recently changes in the myoepithelial cells (MECs) have been implicated. The aim of this study is to investigate the changes in gene profile of MECs in D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e8dbdf1e2991489b6edaaf8d9401f5
https://doi.org/10.1097/pai.0000000000001028

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