Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Dylan J, Taatjes"'
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J. McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produc
Externí odkaz:
https://doaj.org/article/f640317b562445dfa0b4f3772b68e0d1
Autor:
Jonathan D. Rubin, Jacob T. Stanley, Rutendo F. Sigauke, Cecilia B. Levandowski, Zachary L. Maas, Jessica Westfall, Dylan J. Taatjes, Robin D. Dowell
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Rubin et al. introduce transcription factor enrichment analysis (TFEA), a new motif enrichment method specifically aimed at maximizing the informative nature of differential RNA polymerase initiation data. It provides an easy, rigorous, and cost-effe
Externí odkaz:
https://doaj.org/article/5efe066cfacc491fafa057cc4297ed32
Autor:
Benjamin L. Allen, Kim Quach, Taylor Jones, Cecilia B. Levandowski, Christopher C. Ebmeier, Jonathan D. Rubin, Timothy Read, Robin D. Dowell, Alanna Schepartz, Dylan J. Taatjes
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110630- (2022)
Summary: DNA-binding transcription factors (TFs) remain challenging to target with molecular probes. Many TFs function in part through interaction with Mediator, a 26-subunit complex that controls RNA polymerase II activity genome-wide. We sought to
Externí odkaz:
https://doaj.org/article/778fb17bca8f4e708f1fcf23e5732ca5
Autor:
Cecilia B Levandowski, Taylor Jones, Margaret Gruca, Sivapriya Ramamoorthy, Robin D Dowell, Dylan J Taatjes
Publikováno v:
PLoS Biology, Vol 19, Iss 8, p e3001364 (2021)
The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity.
Externí odkaz:
https://doaj.org/article/94aa714894df457982ab202df1437cf9
Autor:
Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M. Cizin, Benjamin M. Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, Norbert F. Käufer, Maxim V. Dorovkov, Alexey G. Ryazanov, Yuichiro Takagi, Edward R. Kastenhuber, Marcus D. Goncalves, Benjamin D. Hopkins, Olivier Elemento, Dylan J. Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V. Hornbeck, Benjamin E. Turk, Michael B. Yaffe, Lewis C. Cantley
Publikováno v:
Nature. 613:759-766
Protein phosphorylation is one of the most widespread post-translational modifications in biology1,2. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24067cbcb16c95a6f48186aaec1c115c
https://doi.org/10.1038/s41586-022-05575-3
https://doi.org/10.1038/s41586-022-05575-3
Autor:
Christopher C. Ebmeier, Benjamin Erickson, Benjamin L. Allen, Mary A. Allen, Hyunmin Kim, Nova Fong, Jeremy R. Jacobsen, Kaiwei Liang, Ali Shilatifard, Robin D. Dowell, William M. Old, David L. Bentley, Dylan J. Taatjes
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1173-1186 (2017)
Summary: CDK7 phosphorylates the RNA polymerase II (pol II) C-terminal domain CTD and activates the P-TEFb-associated kinase CDK9, but its regulatory roles remain obscure. Here, using human CDK7 analog-sensitive (CDK7as) cells, we observed reduced ca
Externí odkaz:
https://doaj.org/article/388167747535488082fda9ce7d8b4cb5
Publikováno v:
Nature Reviews Molecular Cell Biology. 23:732-749
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining feature of Mediator is its intrinsic disorder and conformational flexibil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7683aed60f3e418320c08f1e8b09f50d
https://doi.org/10.1038/s41580-022-00498-3
https://doi.org/10.1038/s41580-022-00498-3
Autor:
Zachary C. Poss, Christopher C. Ebmeier, Aaron T. Odell, Anupong Tangpeerachaikul, Thomas Lee, Henry E. Pelish, Matthew D. Shair, Robin D. Dowell, William M. Old, Dylan J. Taatjes
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 436-450 (2016)
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116). We identified over 16,000 quantified phosphosites i
Externí odkaz:
https://doaj.org/article/5d3ce4cfad3a4795abef5531aa404cc4
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6680a174951b6e46872d5d13c55fc4f
https://doi.org/10.1101/2022.09.17.508384
https://doi.org/10.1101/2022.09.17.508384
Autor:
Dylan J. Taatjes, Allison C. Schier
Publikováno v:
Nature Structural & Molecular Biology. 28:540-543
After years of only low-resolution and partial assemblies, the entire human preinitiation complex (PIC), including the large and flexible Mediator and TFIID complexes, has come into focus. Five recent papers from three different research groups have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7401b70bea1d95997adf41f1ec058fad
https://doi.org/10.1038/s41594-021-00613-6
https://doi.org/10.1038/s41594-021-00613-6