Výsledky vyhledávání - "Dylan Iannitelli"

Akademický článek

Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons

Autor: Ana Paula Zen Petisco Fiore, Shuvadeep Maity, Lauren Jeffery, Disi An, Justin Rendleman, Dylan Iannitelli, Hyungwon Choi, Esteban Mazzoni, Christine Vogel

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113885- (2024)

Summary: Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we exposed induced cranial and spinal motor neurons (iCrMNs and iSpMNs

Externí odkaz: https://doaj.org/article/ec67cb62c095414cb313530ab059cdee

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New molecular signatures defining the differential proteostasis response in ALS-resistant and -sensitive motor neurons

Autor: Ana Paula Zen Petisco Fiore, Shuvadeep Maity, Disi An, Justin Rendleman, Dylan Iannitelli, Hyungwon Choi, Esteban Mazzoni, Christine Vogel

Amyotrophic Lateral Sclerosis (ALS) is a fatal adult neurodegenerative disease characterized by proteostasis dysregulation, resulting in progressive loss of spinal and upper motor neurons. A subset of cranial motor neurons resistant to ALS-stress sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50f393a58562ae853e44da6d44296fa5
https://doi.org/10.1101/2022.04.10.487765

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