Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dylan C. Mitchell"'
Publikováno v:
eLife, Vol 10 (2021)
Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increas
Externí odkaz:
https://doaj.org/article/9eaf719877654e798fcc33f219285582
Autor:
Dylan C. Mitchell, Miljan Kuljanin, Jiaming Li, Jonathan G. Van Vranken, Nathan Bulloch, Devin K. Schweppe, Edward L. Huttlin, Steven P. Gygi
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a210bf23be62c5c54982c849745fab1
https://doi.org/10.1038/s41587-022-01539-0
https://doi.org/10.1038/s41587-022-01539-0
Autor:
Dylan C, Mitchell, Miljan, Kuljanin, Jiaming, Li, Jonathan G, Van Vranken, Nathan, Bulloch, Devin K, Schweppe, Edward L, Huttlin, Steven P, Gygi
Publikováno v:
Nature biotechnology.
Defining the cellular response to pharmacological agents is critical for understanding the mechanism of action of small molecule perturbagens. Here, we developed a 96-well-plate-based high-throughput screening infrastructure for quantitative proteomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af4d6f97e05cc8b0dca8519a5e83bb2a
https://pubmed.ncbi.nlm.nih.gov/36593396
https://pubmed.ncbi.nlm.nih.gov/36593396
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd248ceabb56262136cf892f2aebdccf
https://elifesciences.org/articles/70784
https://elifesciences.org/articles/70784
Publikováno v:
Journal of Biological Chemistry. 294:17188-17196
MicroRNAs (miRNAs or miRs) are small, noncoding RNAs that are implicated in the regulation of most biological processes. Global miRNA biogenesis is altered in many cancers, and RNA-binding proteins play a role in miRNA biogenesis, presenting a promis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb005b292e0d201ed0902d922e6b823
https://doi.org/10.1074/jbc.ac119.010419
https://doi.org/10.1074/jbc.ac119.010419
Publikováno v:
Proc Natl Acad Sci U S A
The Arg/N-degron pathway targets proteins for degradation by recognizing their N-terminal or internal degrons. Our previous work produced double-knockout (2-KO) HEK293T human cell lines that lacked the functionally overlapping UBR1 and UBR2 E3 ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffff79d8f3b1d83722d99ee85bcf1b2
https://europepmc.org/articles/PMC7733807/
https://europepmc.org/articles/PMC7733807/
Autor:
Vibha N. Lama, A. Lock, K. Misumi, Amanda L. Garner, Michael P. Combs, David S. Wheeler, G. Kleer, Dylan C. Mitchell, N.M. Walker
Publikováno v:
D77. TRANSPLANTATION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91aa9d109d167d6b725e509aef1bc293
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7585
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7585
Autor:
David P. Nusinow, Steven P. Gygi, Benjamin F. Cravatt, Joseph D. Mancias, Miljan Kuljanin, Eric T. Kool, Ajami Gikandi, Devin K. Schweppe, Dylan C. Mitchell, Ekaterina V. Vinogradova, David L. Wilson, Nathan J. Bulloch
Publikováno v:
Nat Biotechnol
Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the proteome. Here we redesigned the workflow for activity-based protein profiling of reactive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73851ba1a03f2eef7e89377fb712e074
https://pubmed.ncbi.nlm.nih.gov/33398154
https://pubmed.ncbi.nlm.nih.gov/33398154
Autor:
Zhenying Cai, Steven P. Gygi, Joao A. Paulo, Jiaming Li, Ning Shen, Dylan C. Mitchell, Edward L. Huttlin, Brian L. Harry, Laura Pontano Vaites
Publikováno v:
Mol Cell
Rapid protein degradation enables cells to quickly modulate protein abundance. Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A focused map of short-lived proteins remains understudied. Cycloheximide, a translati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d05e18d9d26c4657311d1de0aba2e1b
https://doi.org/10.1016/j.molcel.2021.09.015
https://doi.org/10.1016/j.molcel.2021.09.015