Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Dylan B. Udy"'
Autor:
Jacob T Polaski, Dylan B Udy, Luisa F Escobar-Hoyos, Gokce Askan, Steven D Leach, Andrea Ventura, Ram Kannan, Robert K Bradley
Publikováno v:
eLife, Vol 10 (2021)
Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subse
Externí odkaz:
https://doaj.org/article/a9463db9934743749b34293a37a365ef
Autor:
Khrystyna North, Salima Benbarche, Bo Liu, Joseph Pangallo, Sisi Chen, Maximilian Stahl, Jan Philipp Bewersdorf, Robert F. Stanley, Caroline Erickson, Hana Cho, Jose Mario Bello Pineda, James D. Thomas, Jacob T. Polaski, Andrea E. Belleville, Austin M. Gabel, Dylan B. Udy, Olivier Humbert, Hans-Peter Kiem, Omar Abdel-Wahab, Robert K. Bradley
Publikováno v:
Nature Biotechnology. 40:1103-1113
Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors. Here, we describe a method to harness this abnormal splicing activity to drive splicing factor mutation-dependent gene expression to selectively eliminate tumo
Publikováno v:
Life Science Alliance. 6:e202201889
Recursive splicing is a non-canonical splicing mechanism in which an intron is removed in segments via multiple splicing reactions. Relatively few recursive splice sites have been identified with high confidence in human introns, and more comprehensi
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134738 (2015)
The rat kangaroo (long-nosed potoroo, Potorous tridactylus) is a marsupial native to Australia. Cultured rat kangaroo kidney epithelial cells (PtK) are commonly used to study cell biological processes. These mammalian cells are large, adherent, and f
Externí odkaz:
https://doaj.org/article/9d7ac074267f409d96d0d16a94d11167
Autor:
Robert K. Bradley, Dylan B. Udy
Nonsense-mediated mRNA decay (NMD) is an essential, highly conserved quality control pathway that detects and degrades mRNAs containing premature termination codons (PTCs). Although the essentiality of NMD is frequently ascribed to its prevention of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d56fa6047030faab5a9c164a89f7980
https://doi.org/10.1101/2021.05.24.445486
https://doi.org/10.1101/2021.05.24.445486
Autor:
Gokce Askan, Jacob T. Polaski, Robert K. Bradley, Luisa F. Escobar-Hoyos, Andrea Ventura, Ram Kannan, Steven D. Leach, Dylan B. Udy
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a nonsense-mediated mRNA decay (NMD) factor, in PASC, but subse
Author response: The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma
Autor:
Robert K. Bradley, Jacob T. Polaski, Andrea Ventura, Steven D. Leach, Luisa F. Escobar-Hoyos, Gokce Askan, Ram Kannan, Dylan B. Udy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb79c425075a5cc6959798233efbda8
https://doi.org/10.7554/elife.62209.sa2
https://doi.org/10.7554/elife.62209.sa2
Autor:
Luisa F. Escobar-Hoyos, Gokce Askan, Jacob T. Polaski, Ram Kannan, Dylan B. Udy, Robert K. Bradley, Andrea Ventura, Steven D. Leach
Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive subtype of pancreatic cancer whose mutational origins are poorly understood. An early study reported somatic mutations in UPF1, which encodes a core component of the nonsense-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba06bf91b574f51658c2fb6edd7db4ce
https://doi.org/10.1101/2020.08.14.248864
https://doi.org/10.1101/2020.08.14.248864
Publikováno v:
Current biology : CB, vol 27, iss 14
Active forces generated at kinetochores move chromosomes, and the dynamic spindle must robustly anchor kinetochore fibers (k-fibers) to bear this load. The mammalian spindle bears the load of chromosome movement far from poles, but we do not know whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc3794412a38fa6cd5c16337b8691a3
https://escholarship.org/uc/item/3nv7k2wb
https://escholarship.org/uc/item/3nv7k2wb
SummaryThe kinetochore links chromosomes to dynamic spindle microtubules and drives both chromosome congression and segregation. To do so, the kinetochore must hold on to depolymerizing and polymerizing microtubules. At metaphase, one sister kinetoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ae0e675dc6add4c3bb41a46a970689
https://doi.org/10.1101/105916
https://doi.org/10.1101/105916