Výsledky vyhledávání - "Dylan, Postmus"

Akademický článek

Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human diseaseResearch in context

Publikováno v: EBioMedicine, Vol 108, Iss , Pp 105312- (2024)

Summary: Background: Translating findings from animal models to human disease is essential for dissecting disease mechanisms, developing and testing precise therapeutic strategies. The coronavirus disease 2019 (COVID-19) pandemic has highlighted this

Externí odkaz: https://doaj.org/article/550b504cdf1443abbb5bb72c0b333a6c

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Akademický článek

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

Autor: Stefan Peidli, Geraldine Nouailles, Emanuel Wyler, Julia M. Adler, Sandra Kunder, Anne Voß, Julia Kazmierski, Fabian Pott, Peter Pennitz, Dylan Postmus, Luiz Gustavo Teixeira Alves, Christine Goffinet, Achim D. Gruber, Nils Blüthgen, Martin Witzenrath, Jakob Trimpert, Markus Landthaler, Samantha D. Praktiknjo

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114328- (2024)

Summary: A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we further

Externí odkaz: https://doaj.org/article/c99d11239614470a8f8f7a476d42cda0

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Akademický článek

Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.

Publikováno v: PLoS Pathogens, Vol 19, Iss 9, p e1011657 (2023)

Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its susceptibili

Externí odkaz: https://doaj.org/article/68f2a8478fe7484fafc679780534d4ce

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Akademický článek

Nonproductive exposure of PBMCs to SARS‐CoV‐2 induces cell‐intrinsic innate immune responses

Autor: Julia Kazmierski, Kirstin Friedmann, Dylan Postmus, Jackson Emanuel, Cornelius Fischer, Jenny Jansen, Anja Richter, Laure Bosquillon de Jarcy, Christiane Schüler, Madlen Sohn, Sascha Sauer, Christian Drosten, Antoine‐Emmanuel Saliba, Leif Erik Sander, Marcel A Müller, Daniela Niemeyer, Christine Goffinet

Publikováno v: Molecular Systems Biology, Vol 18, Iss 8, Pp 1-16 (2022)

Abstract Cell‐intrinsic responses mounted in PBMCs during mild and severe COVID‐19 differ quantitatively and qualitatively. Whether they are triggered by signals emitted by productively infected cells of the respiratory tract or result from physi

Externí odkaz: https://doaj.org/article/bd2eb001419145ec893ee0b1a1a9d093

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Akademický článek

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmon

Externí odkaz: https://doaj.org/article/072ec28bf61e4f88ac379cb3aa53c111

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Akademický článek

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression

Autor: Fabian Pott, Dylan Postmus, Richard J. P. Brown, Emanuel Wyler, Elena Neumann, Markus Landthaler, Christine Goffinet

Publikováno v: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2151-2168 (2021)

Infection by (re-)emerging RNA arboviruses including Chikungunya virus (CHIKV) and Mayaro virus primarily cause acute febrile disease and transient polyarthralgia. However, in a significant subset of infected individuals, debilitating arthralgia pers

Externí odkaz: https://doaj.org/article/b4572736f4fa4d98b4dc42c21f980331

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Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression

Autor: Christine Goffinet, Dylan Postmus, Fabian Pott, Emanuel Wyler, Richard J. C. Brown, Elena Neumann, Markus Landthaler

Publikováno v: Emerging Microbes & Infections
article-version (VoR) Version of Record
Emerging Microbes & Infections, 10:2151-2168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1000e81e355b00ff686deab86ae088
http://europepmc.org/articles/PMC8604527

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