Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Dying Back"'
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-24 (2022)
Abstract Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43, which are detected in nearly all patients. Mutations in the gene t
Externí odkaz:
https://doaj.org/article/296d3560e94946f1abcb4b4054464963
Autor:
Priyanka Bhatia, Marc Bickle, Amay A. Agrawal, Buster Truss, Aikaterina Nikolaidi, Kathrin Brockmann, Lydia Reinhardt, Stefanie Vogel, Eva M. Szegoe, Arun Pal, Andreas Hermann, Ivan Mikicic, Maximina Yun, Björn Falkenburger, Jared Sterneckert
Publikováno v:
Biology, Vol 13, Iss 1, p 58 (2024)
The degeneration of axon terminals before the soma, referred to as “dying back”, is a feature of Parkinson’s disease (PD). Axonal assays are needed to model early PD pathogenesis as well as identify protective therapeutics. We hypothesized that
Externí odkaz:
https://doaj.org/article/4952ffb943c34abcbcc6ad2a203b9ec1
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 3, Pp 655-660 (2022)
The dying-back hypothesis holds that the damage to neuromuscular junctions and distal axons in amyotrophic lateral sclerosis occurs at the earliest stage of the disease. Previous basic studies have confirmed early damage to neuromuscular junctions, b
Externí odkaz:
https://doaj.org/article/c02e93445df54ecc8f5635cb2e109f8f
Autor:
Ingrid Morales, Ricardo Puertas-Avendaño, Alberto Sanchez, Adrian Perez-Barreto, Clara Rodriguez-Sabate, Manuel Rodriguez
Publikováno v:
Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-19 (2021)
Abstract Objective The dopaminergic nigrostriatal neurons (DA cells) in healthy people present a slow degeneration with aging, which produces cellular debris throughout life. About 2%–5% of people present rapid cell degeneration of more than 50% of
Externí odkaz:
https://doaj.org/article/3d0202c695e94f52b84b5ed47935c4a1
Autor:
Katherine L Marshall, Mohamed H Farah
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 10, Pp 1901-1910 (2021)
Nervous system disorders are prevalent health issues that will only continue to increase in frequency as the population ages. Dying-back axonopathy is a hallmark of many neurologic diseases and leads to axonal disconnection from their targets, which
Externí odkaz:
https://doaj.org/article/17bac7f01d744405be0aa92a5b62a1a5
Publikováno v:
Cells, Vol 11, Iss 8, p 1358 (2022)
Axonal degeneration is an active process that differs from neuronal death, and it is the hallmark of many disorders affecting the central and peripheral nervous system. Starting from the analyses of Wallerian degeneration, the simplest experimental m
Externí odkaz:
https://doaj.org/article/49ffa14af06643d2bf7db327d7bb6a20
Akademický článek
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Autor:
Bhatia, Priyanka
A striking feature of Parkinson's disease (PD) is that the distal axonal terminals of neurons degenerate prior to the soma, a process referred to as 'dying-back'. Another hallmark of the disease is the pathological accumulation of abnormal protein ag
Externí odkaz:
https://tud.qucosa.de/id/qucosa%3A90019
https://tud.qucosa.de/api/qucosa%3A90019/attachment/ATT-0/
https://tud.qucosa.de/api/qucosa%3A90019/attachment/ATT-0/
Autor:
Xiao-Sun Sun, Wen-Xiu Liu, Zhao-Hui Chen, Li Ling, Fei Yang, Hong-Fen Wang, Fang Cui, Xu-Sheng Huang
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 18, Pp 2146-2151 (2018)
Background: Nowadays, it is widely known that decremental responses in low-frequency repetitive nerve stimulation (LF-RNS) are frequently observed in patients with amyotrophic lateral sclerosis (ALS). The pathological mechanism of this phenomenon rem
Externí odkaz:
https://doaj.org/article/c608dbb7ffa7408ba39be09c6bdf3cd7
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 300-320 (2017)
Peripheral neuropathies are characterized by a progressive and length-dependent loss of peripheral nerve function. This can be caused either by genetic defects, classified as ‘inherited peripheral neuropathies’, or they can be acquired throughout
Externí odkaz:
https://doaj.org/article/e682f9c0866c4c3d84e021581525b5aa