Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Dyfrig A Hughes"'
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-8 (2023)
Abstract Background The Orphan Regulation ((EC) No 141/2000) has successfully redirected private and public investment towards previously neglected areas through incentives, regulatory obligations and rewards. However, the growth in the number of lic
Externí odkaz:
https://doaj.org/article/be581134551441ebb3b366087c16bb91
Autor:
Nikki Totton, Steven A Julious, Elizabeth Coates, Dyfrig A Hughes, Jonathan A Cook, Katie Biggs, Catherine Hewitt, Simon Day, Andrew Cook
Publikováno v:
Health Technology Assessment, Vol 27, Iss 20 (2023)
Background Randomised controlled trials are designed to assess the superiority, equivalence or non-inferiority of a new health technology, but which trial design should be used is not always obvious in practice. In particular, when using equivalence
Externí odkaz:
https://doaj.org/article/6052928af16542beb9230ebba626f998
Autor:
Andrea L Jorgensen, Catherine Orrell, Catriona Waitt, Cheng-Hock Toh, Christine Sekaggya-Wiltshire, Dyfrig A Hughes, Elizabeth Allen, Emmy Okello, Gayle Tatz, Giovanna Culeddu, Innocent G Asiimwe, Jerome Roy Semakula, Johannes P Mouton, Karen Cohen, Marc Blockman, Mohammed Lamorde, Munir Pirmohamed
Publikováno v:
JMIR Research Protocols, Vol 12, p e46710 (2023)
BackgroundThe quality of warfarin anticoagulation among Sub-Saharan African patients is suboptimal. This is due to several factors, including a lack of standardized dosing algorithms, difficulty in providing timely international normalized ratio (INR
Externí odkaz:
https://doaj.org/article/8aa9d5caf1144261bbc13fcb1b01ef6e
Autor:
Dyfrig A Hughes, Emily A Holmes, Christian Subbe, Cor Kalkman, John Welch, Sally Lewis, Ralph So, Sumeshni Tranka
Publikováno v:
BMJ Open, Vol 13, Iss 4 (2023)
Objectives Failure to rescue deteriorating patients in hospital is a well-researched topic. We aimed to explore the impact of safer care on health economic considerations for clinicians, providers and policymakers.Design We undertook a rapid review o
Externí odkaz:
https://doaj.org/article/86d6f3181e494c099dc19482990bd444
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Objective To ascertain the burden and associated cost of adverse drug reactions (ADRs), polypharmacy and multimorbidity through a prospective analysis of all medical admissions to a large university teaching hospital over a 1-month period.Design Pros
Externí odkaz:
https://doaj.org/article/e441b2cfe7164c92973ca0346b945ad9
Autor:
Anthony G Marson, Girvan Burnside, Richard Appleton, Dave Smith, John Paul Leach, Graeme Sills, Catrin Tudur-Smith, Catrin O Plumpton, Dyfrig A Hughes, Paula R Williamson, Gus Baker, Silviya Balabanova, Claire Taylor, Richard Brown, Dan Hindley, Stephen Howell, Melissa Maguire, Rajiv Mohanraj, Philip EM Smith
Publikováno v:
Health Technology Assessment, Vol 25, Iss 75 (2021)
Background: Levetiracetam (Keppra®, UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran®, Eisai Co. Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for generalised
Externí odkaz:
https://doaj.org/article/a6bb255ed29d423996d9ff3ae50435f9
Publikováno v:
BMJ Open, Vol 11, Iss 12 (2021)
Externí odkaz:
https://doaj.org/article/7ae55a8dbd6c42dba846621a33ad2b67
Publikováno v:
BMJ Open, Vol 11, Iss 5 (2021)
Objective The aim of this economic evaluation was to assess whether home management could represent a cost-effective strategy in the patient pathway of type 1 diabetes (T1D). This is based on the Delivering Early Care In Diabetes Evaluation trial (IS
Externí odkaz:
https://doaj.org/article/3efbbcda382841b0a1ed25036a83051e
Autor:
Martin J Wilby, Ashley Best, Eifiona Wood, Girvan Burnside, Emma Bedson, Hannah Short, Dianne Wheatley, Daniel Hill-McManus, Manohar Sharma, Simon Clark, Jennifer Bostock, Sally Hay, Ganesan Baranidharan, Cathy Price, Richard Mannion, Peter J Hutchinson, Dyfrig A Hughes, Anthony Marson, Paula R Williamson
Publikováno v:
Health Technology Assessment, Vol 25, Iss 24 (2021)
Background: Sciatica is a common condition reported to affect > 3% of the UK population at any time and is most often caused by a prolapsed intervertebral disc. Currently, there is no uniformly adopted treatment strategy. Invasive treatments, such as
Externí odkaz:
https://doaj.org/article/822c34010724485e9bf788140139f60f
Autor:
Ian Sinha, Dyfrig A Hughes, Michelle Maden, Stephen Turner, Sofia Cividini, Sarah Donegan, Giovanna Culeddu, Katie Rose, Olive Fulton, Catrin Tudur Smith
Publikováno v:
BMJ Open, Vol 11, Iss 2 (2021)
Introduction Asthma affects millions of children worldwide—1.1 million children in the UK. Asthma symptoms cannot be cured but can be controlled with low-dose inhaled corticosteroids (ICSs) in the majority of individuals. Treatment with a low-dose
Externí odkaz:
https://doaj.org/article/416ef080f25544cfb336112aae0e5fd5