A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function

Autor: Higman, VA, Briggs, DC, Mahoney, DJ, Blundell, CD, Sattelle, BM, Dyer, DP, Green, DE, DeAngelis, PL, Almond, A, Milner, CM, Day, AJ

Tumor necrosis factor-stimulated gene-6 (TSG-6) is an inflammation-associated hyaluronan (HA)-binding protein that contributes to remodeling of HA-rich extracellular matrices during inflammatory processes and ovulation. The HA-binding domain of TSG-6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b272db13caafb659ca1b27bd790a935
https://ora.ox.ac.uk/objects/uuid:404384b1-132a-49ab-862c-efa6b64e2542

A systematic review of normal tissue neurovascular unit damage following brain irradiation-Factors affecting damage severity and timing of effects.

Autor: Nakkazi A; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, The University of Manchester, Manchester, UK.; Faculty of Biology, Medicine, and Health, Division of Informatics, Imaging, and Data Sciences, School of Health Sciences, The University of Manchester, Manchester, UK., Forster D; Faculty of Biology, Medicine, and Health, Division of Informatics, Imaging, and Data Sciences, School of Health Sciences, The University of Manchester, Manchester, UK., Whitfield GA; Division of Cancer Sciences, Manchester Cancer Research Centre, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Dyer DP; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, The University of Manchester, Manchester, UK., Dickie BR; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, The University of Manchester, Manchester, UK.; Faculty of Biology, Medicine, and Health, Division of Informatics, Imaging, and Data Sciences, School of Health Sciences, The University of Manchester, Manchester, UK.

Publikováno v: Neuro-oncology advances [Neurooncol Adv] 2024 Jun 13; Vol. 6 (1), pp. vdae098. Date of Electronic Publication: 2024 Jun 13 (Print Publication: 2024).

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans.

Autor: Ridley AJL; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Ou Y; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Karlsson R; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark., Pun N; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Birchenough HL; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Mulholland IZ; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Birch ML; Biological Services Facility, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK., MacDonald AS; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Jowitt TA; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Lawless C; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK., Miller RL; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark., Dyer DP; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester M6 8HD, UK.

Publikováno v: Science signaling [Sci Signal] 2023 Nov 07; Vol. 16 (810), pp. eadf2537. Date of Electronic Publication: 2023 Nov 07.

Increased Circulating Chemokines and Macrophage Recruitment in Growing Vestibular Schwannomas.

Autor: Hannan CJ; Manchester Centre for Clinical Neurosciences, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Cardiovascular Sciences, University of Manchester, UK., Lewis D; Manchester Centre for Clinical Neurosciences, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Neuroscience and Experimental Psychology, University of Manchester, UK., O'Leary C; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Neuroscience and Experimental Psychology, University of Manchester, UK., Waqar M; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Neuroscience and Experimental Psychology, University of Manchester, UK., Brough D; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Neuroscience and Experimental Psychology, University of Manchester, UK.; Lydia Becker Institute of Inflammation and Immunology, University of Manchester, UK., Couper KN; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Lydia Becker Institute of Inflammation and Immunology, University of Manchester, UK., Dyer DP; Wellcome Centre for Cell-Matrix Research, University of Manchester, UK., Vail A; Centre for Biostatistics, University of Manchester, UK., Heal C; Centre for Biostatistics, University of Manchester, UK., Macarthur J; School of Medicine, University of Manchester, UK., Cooper C; School of Medicine, University College London, UK., Hammerbeck-Ward C; Manchester Centre for Clinical Neurosciences, Manchester, UK., Evans DG; St. Mary's Centre for Genomic Medicine.; Division of Evolution and Genomic Sciences, University of Manchester, UK., Rutherford SA; Manchester Centre for Clinical Neurosciences, Manchester, UK., Lloyd SK; Division of Neuroscience and Experimental Psychology, University of Manchester, UK.; Department of Otolaryngology, Manchester University NHS Foundation Trust, Manchester, UK.; Department of Otolaryngology, Salford Royal Hospital, Manchester, UK., Mackenzie Freeman SR; Division of Neuroscience and Experimental Psychology, University of Manchester, UK.; Department of Otolaryngology, Salford Royal Hospital, Manchester, UK., Coope DJ; Manchester Centre for Clinical Neurosciences, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Neuroscience and Experimental Psychology, University of Manchester, UK., King AT; Manchester Centre for Clinical Neurosciences, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Cardiovascular Sciences, University of Manchester, UK., Pathmanaban ON; Manchester Centre for Clinical Neurosciences, Manchester, UK.; Geoffrey Jefferson Brain Research Centre, Manchester, UK.; Division of Neuroscience and Experimental Psychology, University of Manchester, UK.

Publikováno v: Neurosurgery [Neurosurgery] 2023 Mar 01; Vol. 92 (3), pp. 581-589. Date of Electronic Publication: 2022 Dec 12.

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors.

Autor: Gray AL; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, UK., Karlsson R; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Roberts ARE; University of Leeds, School of Biomedical Sciences, Faculty of Biological Sciences, School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, Astbury Centre for Structural Molecular Biology, and Bragg Centre for Materials Research, Leeds LS2 9JT, UK., Ridley AJL; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Pun N; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Khan B; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Lawless C; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Luís R; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg; Tumor Immunotherapy and Microenvironment, Department of Cancer Research, Luxembourg Institute of Health, 2012 Luxembourg, Luxembourg., Szpakowska M; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg., Chevigné A; Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg., Hughes CE; Chemokine Research Group, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Medina-Ruiz L; Chemokine Research Group, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Birchenough HL; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Mulholland IZ; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Salanga CL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Yates EA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK., Turnbull JE; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK; Centre for Glycosciences, Keele University, Keele, Staffordshire ST5 5BG, UK., Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Graham GJ; Chemokine Research Group, School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Jowitt TA; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Schiessl I; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, UK; Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Richter RP; University of Leeds, School of Biomedical Sciences, Faculty of Biological Sciences, School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, Astbury Centre for Structural Molecular Biology, and Bragg Centre for Materials Research, Leeds LS2 9JT, UK., Miller RL; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Dyer DP; Wellcome Centre for Cell-Matrix Research, Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, UK. Electronic address: douglas.dyer@manchester.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 111930. Date of Electronic Publication: 2023 Jan 05.