A Longitudinal Analysis of Memory Immune Responses in Convalescent Crimean-Congo Hemorrhagic Fever Survivors in Uganda.

Autor: Cohen CA; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Balinandi S; Department of Arbovirology, Medical Research Council/Uganda Viral Research Institute, Entebbe, Uganda., Kuehne AI; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Rock ML; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA.; The Geneva Foundation, Tacoma, Washington, USA., Bonagofski LG; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Ricks KM; Diagnostic Systems Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Davis I; Diagnostic Systems Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Abelson D; Mapp Biopharmaceutical, San Diego, California, USA., Stonier SW; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Odongo M; Department of Arbovirology, Medical Research Council/Uganda Viral Research Institute, Entebbe, Uganda., Bornholdt ZA; Mapp Biopharmaceutical, San Diego, California, USA., Zeitlin L; Mapp Biopharmaceutical, San Diego, California, USA., Moyer C; Mapp Biopharmaceutical, San Diego, California, USA., Cose S; Department of Arbovirology, Medical Research Council/Uganda Viral Research Institute, Entebbe, Uganda.; London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Dye JM; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA., Lutwama JJ; Department of Arbovirology, Medical Research Council/Uganda Viral Research Institute, Entebbe, Uganda., Herbert AS; Virology Division, US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.

Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38.

Autor: Shin OS; Adimab, LLC, Lebanon, NH 03766, USA., Monticelli SR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; Geneva Foundation, Tacoma, WA 98042, USA., Hjorth CK; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Hornet V; Adimab, LLC, Lebanon, NH 03766, USA., Doyle M; Adimab, LLC, Lebanon, NH 03766, USA., Abelson D; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Wang A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Mishra AK; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Middlecamp M; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Champney E; Adimab, LLC, Lebanon, NH 03766, USA., Stuart L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Maurer DP; Adimab, LLC, Lebanon, NH 03766, USA., Li J; Adimab, LLC, Lebanon, NH 03766, USA., Berrigan J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Barajas J; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Balinandi S; Uganda Virus Research Institute, Entebbe, Uganda., Lutwama JJ; Uganda Virus Research Institute, Entebbe, Uganda., Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel., Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Walker LM; Adimab, LLC, Lebanon, NH 03766, USA., Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: andrew.s.herbert4.civ@health.mil., Pauli NT; Adimab, LLC, Lebanon, NH 03766, USA. Electronic address: noel.pauli@adimab.com., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: jmclellan@austin.utexas.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114502. Date of Electronic Publication: 2024 Jul 13.

Crimean-Congo Hemorrhagic Fever Survivors Elicit Protective Non-Neutralizing Antibodies that Target 11 Overlapping Regions on Viral Glycoprotein GP38.

Autor: Shin OS; Adimab, LLC, Lebanon, NH 03766, USA., Monticelli SR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98042, USA., Hjorth CK; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Hornet V; Adimab, LLC, Lebanon, NH 03766, USA., Doyle M; Adimab, LLC, Lebanon, NH 03766, USA., Abelson D; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Wang A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Mishra A; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA., Middlecamp M; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Champney E; Adimab, LLC, Lebanon, NH 03766, USA., Stuart L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Maurer DP; Adimab, LLC, Lebanon, NH 03766, USA., Li J; Adimab, LLC, Lebanon, NH 03766, USA., Berrigan J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Barajas J; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Balinandi S; Uganda Virus Research Institute, Entebbe, Uganda., Lutwama JJ; Uganda Virus Research Institute, Entebbe, Uganda., Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel., Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA., Walker LM; Adimab, LLC, Lebanon, NH 03766, USA., Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA., Pauli NT; Adimab, LLC, Lebanon, NH 03766, USA., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 06. Date of Electronic Publication: 2024 Mar 06.

SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.

Autor: Goike J; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Hsieh CL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Horton AP; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA., Gardner EC; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Zhou L; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Bartzoka F; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Javanmardi K; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Herbert A; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA., Abbassi S; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA., Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Xia H; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Renberg R; DEVCOM Army Research Laboratory, Biotechnology Branch, Adelphi, MD, USA., Segall-Shapiro TH; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.; DEVCOM Army Research Laboratory-South, Austin, TX, USA., Terrace CI; DEVCOM Army Research Laboratory-South, Austin, TX, USA., Wu W; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA., Shroff R; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.; DEVCOM Army Research Laboratory-South, Austin, TX, USA., Byrom M; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Ellington AD; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA., Marcotte EM; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Musser JM; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA., Kuchipudi SV; Department of Veterinary and Biomedical Science and Animal Diagnostic Laboratory, The Pennsylvania State University, University Park, PA, USA., Kapur V; Department of Animal Science and the Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA., Georgiou G; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Weaver SC; University of Texas Medical Branch, World Reference Center for Emerging Viruses and Arboviruses, Galveston, TX, USA., Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA., Boutz DR; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. drboutz@houstonmethodist.org.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. drboutz@houstonmethodist.org.; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA. drboutz@houstonmethodist.org.; DEVCOM Army Research Laboratory-South, Austin, TX, USA. drboutz@houstonmethodist.org., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. jmclellan@austin.utexas.edu., Gollihar JD; Center for Systems and Synthetic Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. jgollihar2@houstonmethodist.org.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. jgollihar2@houstonmethodist.org.; Antibody Discovery and Accelerated Protein Therapeutics, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA. jgollihar2@houstonmethodist.org.; DEVCOM Army Research Laboratory-South, Austin, TX, USA. jgollihar2@houstonmethodist.org.

Publikováno v: Communications biology [Commun Biol] 2023 Dec 11; Vol. 6 (1), pp. 1250. Date of Electronic Publication: 2023 Dec 11.

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing.

Autor: Zumbrun EE; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Garvey CB; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Wells JB; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Lynn GC; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Van Tongeren S; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Steffens JT; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Wetzel KS; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Gomba LM; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., O'Brien KA; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Rossi FD; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Zeng X; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Lee ED; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Raymond JLW; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Hoffman DA; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Jay AN; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Brown ES; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Geneva Foundation, Tacoma, WA 98402, USA., Kallgren PA; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Norris SL; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA., Cantey-Kiser J; PharPoint, Wilmington, NC 28405, USA., Kudiya H; Gilead Sciences, Foster City, CA 94404, USA., Arthur C; Gilead Sciences, Foster City, CA 94404, USA., Blair C; Gilead Sciences, Foster City, CA 94404, USA., Babusis D; Gilead Sciences, Foster City, CA 94404, USA., Chu VC; Gilead Sciences, Foster City, CA 94404, USA., Singh B; Gilead Sciences, Foster City, CA 94404, USA., Bannister R; Gilead Sciences, Foster City, CA 94404, USA., Porter DP; Gilead Sciences, Foster City, CA 94404, USA., Cihlar T; Gilead Sciences, Foster City, CA 94404, USA., Dye JM; United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.

Publikováno v: Viruses [Viruses] 2023 Nov 28; Vol. 15 (12). Date of Electronic Publication: 2023 Nov 28.