Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dyann M. Segvich"'
Autor:
Rachel Kohler, Dyann M. Segvich, Olivia Reul, Corinne E. Metzger, Matthew R. Allen, Joseph M. Wallace
Publikováno v:
Bone Reports, Vol 21, Iss , Pp 101774- (2024)
As international incidence of diabetes and diabetes-driven comorbidities such as chronic kidney disease (CKD) continue to climb, interventions are needed that address the high-risk skeletal fragility of what is a complex disease state. Romosozumab (R
Externí odkaz:
https://doaj.org/article/f2fef5bde2ff4c53b286fc3ce44d9e71
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101609- (2022)
Diabetes Mellitus is a metabolic disease which profoundly affects many organ systems in the body, including the skeleton. As is often the case with biology, there are inherent differences between the sexes when considering skeletal development and di
Externí odkaz:
https://doaj.org/article/8c73847cd5e04060a8d10b4d37717228
Autor:
David S. Watt, Thomas D. Hurley, Mykhaylo S. Frasinyuk, Peter J. Roach, Dyann M. Segvich, Krishna K. Mahalingan, Vimbai M. Chikwana, Cynthia A. Morgan, S. P. Bondarenko, Przemyslaw Wyrebek, Galyna P. Mrug, Anna A. DePaoli-Roach, Buyun Tang
Publikováno v:
J Med Chem
The over-accumulation of glycogen appears as a hallmark in various glycogen storage diseases (GSDs), including Pompe, Cori, Andersen and Lafora disease. Accumulating evidence suggests that suppression of glycogen accumulation represents a potential t
Publikováno v:
SSRN Electronic Journal.
Autor:
Harrison A. Clarke, Craig W. Vander Kooi, Dustin D. Armstrong, Anna A. DePaoli-Roach, Richard R. Drake, Kia H. Markussen, Richard E. Taylor, Jessica K. A. Macedo, Lyndsay E.A. Young, Lindsey R. Conroy, Charles J. Waechter, Matthew S. Gentry, Ronald C. Bruntz, Ramon C. Sun, Christine Fillmore Brainson, Alexandra E. Stanback, Buyun Tang, William C. Sanders, Shane Emanuelle, Dyann M. Segvich, Elizabeth J. Allenger, M. Kathryn Brewer, Peter J. Roach, Krishna K. Mahalingan, Robert Shaffer, Annette Mestas, Vimbai M. Chikwana, Zhengqiu Zhou, Thomas D. Hurley, Tara R. Hawkinson, Alberto Rondon, Christopher J. Contreras, Lance A. Johnson
Publikováno v:
Cell Metab
Summary Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In this study, we found that N-linked protein glycosylation in the brain is metabolic
Autor:
David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, Cheol Soo Choi, Johanna E Snaar, Amanda C McGuire, Sung-Eun Wou, Gemma Medina-Gomez, Sheene Kim, Cheryl B Bock, Dyann M Segvich, Bhavana Solanky, Dinesh Deelchand, Antonio Vidal-Puig, Nicholas J Wareham, Gerald I Shulman, Fredrik Karpe, Roy Taylor, Bartholomew A Pederson, Peter J Roach, Stephen O'Rahilly, Anna A DePaoli-Roach
Publikováno v:
PLoS Medicine, Vol 5, Iss 12 (2008)
Externí odkaz:
https://doaj.org/article/d1e6e766999a48f0b791226f47bd8ce9
Autor:
David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, Cheol Soo Choi, Johanna E Snaar, Amanda C McGuire, Sung-Eun Wou, Gemma Medina-Gomez, Sheene Kim, Cheryl B Bock, Dyann M Segvich, Bhavana Solanky, Dinesh Deelchand, Antonio Vidal-Puig, Nicholas J Wareham, Gerald I Shulman, Fredrik Karpe, Roy Taylor, Bartholomew A Pederson, Peter J Roach, Stephen O'Rahilly, Anna A DePaoli-Roach
Publikováno v:
PLoS Medicine, Vol 5, Iss 1, p e27 (2008)
Stored glycogen is an important source of energy for skeletal muscle. Human genetic disorders primarily affecting skeletal muscle glycogen turnover are well-recognised, but rare. We previously reported that a frameshift/premature stop mutation in PPP
Externí odkaz:
https://doaj.org/article/6ce03d253c6846a6a8db7e41f2d27e2d
Autor:
Grant L. Austin, John J. McCarthy, Annette Uittenbogaard, Jill Zeller, Tracy R. McKnight, Anna A. DePaoli-Roach, Dustin Armstrong, Dyann M. Segvich, M. Kathryn Brewer, James R. Pauly, Bradley L. Hodges, Matthew S. Gentry, Peter J. Roach
Lafora disease (LD) is a fatal childhood epilepsy and a non-classical glycogen storage disorder with no effective therapy or cure. LD is caused by recessive mutations in theEPM2AorEPM2Bgenes that encode the glycogen phosphatase laforin and an E3 ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9082b3cf792132c76aee106501cc36e1
Autor:
Peter J. Roach, Christopher J. Contreras, Anna A. DePaoli-Roach, Thomas D. Hurley, Terence L. Kirley, Dyann M. Segvich, Krishna K. Mahalingan, Vimbai M. Chikwana
Publikováno v:
Archives of Biochemistry and Biophysics. 597:21-29
The storage polymer glycogen normally contains small amounts of covalently attached phosphate as phosphomonoesters at C2, C3 and C6 atoms of glucose residues. In the absence of the laforin phosphatase, as in the rare childhood epilepsy Lafora disease