Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Dyann F Wirth"'
Autor:
Rebecca EK Mandt, Madeline R Luth, Mark A Tye, Ralph Mazitschek, Sabine Ottilie, Elizabeth A Winzeler, Maria Jose Lafuente-Monasterio, Francisco Javier Gamo, Dyann F Wirth, Amanda K Lukens
Publikováno v:
eLife, Vol 12 (2023)
Drug resistance remains a major obstacle to malaria control and eradication efforts, necessitating the development of novel therapeutic strategies to treat this disease. Drug combinations based on collateral sensitivity, wherein resistance to one dru
Externí odkaz:
https://doaj.org/article/0401791b59174b2ea135e6bcfac22ca9
Autor:
Douglas G Paton, Alexandra S Probst, Erica Ma, Kelsey L Adams, W Robert Shaw, Naresh Singh, Selina Bopp, Sarah K Volkman, Domombele F S Hien, Prislaure S L Paré, Rakiswendé S Yerbanga, Abdoullaye Diabaté, Roch K Dabiré, Thierry Lefèvre, Dyann F Wirth, Flaminia Catteruccia
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010609 (2022)
The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public hea
Externí odkaz:
https://doaj.org/article/a1133be8ebf24df9a16f97155b0ec6e5
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009266 (2020)
Malaria continues to impose a significant health burden in the continent of Africa with 213 million cases in 2018 alone, representing 93% of cases worldwide. Because of high transmission of malaria within the continent, the selection pressures to dev
Externí odkaz:
https://doaj.org/article/ae1358c1ac2949019985b2300ff4c7ff
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005923 (2018)
Unlike in most pathogens, multiple-strain (polygenomic) infections of P. falciparum are frequently composed of genetic siblings. These genetic siblings are the result of sexual reproduction and can coinfect the same host when cotransmitted by the sam
Externí odkaz:
https://doaj.org/article/60994e638ebf444c83f927e331b4f9eb
Autor:
Regina N Rabinovich, Chris Drakeley, Abdoulaye A Djimde, B Fenton Hall, Simon I Hay, Janet Hemingway, David C Kaslow, Abdisalan Noor, Fredros Okumu, Richard Steketee, Marcel Tanner, Timothy N C Wells, Maxine A Whittaker, Elizabeth A Winzeler, Dyann F Wirth, Kate Whitfield, Pedro L Alonso
Publikováno v:
PLoS Medicine, Vol 14, Iss 11, p e1002456 (2017)
Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Te
Externí odkaz:
https://doaj.org/article/33c0c487a1e54e7481552d8a89a89914
Autor:
Mary Lynn Baniecki, Aubrey L Faust, Stephen F Schaffner, Daniel J Park, Kevin Galinsky, Rachel F Daniels, Elizabeth Hamilton, Marcelo U Ferreira, Nadira D Karunaweera, David Serre, Peter A Zimmerman, Juliana M Sá, Thomas E Wellems, Lise Musset, Eric Legrand, Alexandre Melnikov, Daniel E Neafsey, Sarah K Volkman, Dyann F Wirth, Pardis C Sabeti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003539 (2015)
Plasmodium vivax, one of the five species of Plasmodium parasites that cause human malaria, is responsible for 25-40% of malaria cases worldwide. Malaria global elimination efforts will benefit from accurate and effective genotyping tools that will p
Externí odkaz:
https://doaj.org/article/61039b73b895415e94caa469820cdeac
Autor:
Amy K Bei, Saurabh D Patel, Sarah K Volkman, Ambroise D Ahouidi, Daouda Ndiaye, Souleymane Mboup, Dyann F Wirth
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90928 (2014)
A challenge to conducting high-impact and reproducible studies of the mechanisms of P. falciparum drug resistance, invasion, virulence, and immunity is the lack of robust and sustainable in vitro culture in the field. While the technology exists and
Externí odkaz:
https://doaj.org/article/0fe6bffebb59450c9398b718a1ff2204
Autor:
Rachel Daniels, Hsiao-Han Chang, Papa Diogoye Séne, Danny C Park, Daniel E Neafsey, Stephen F Schaffner, Elizabeth J Hamilton, Amanda K Lukens, Daria Van Tyne, Souleymane Mboup, Pardis C Sabeti, Daouda Ndiaye, Dyann F Wirth, Daniel L Hartl, Sarah K Volkman
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60780 (2013)
Using parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strain
Externí odkaz:
https://doaj.org/article/175ec21bcce248c7b91a2ee7c51d9502
Autor:
Daria Van Tyne, Daniel J Park, Stephen F Schaffner, Daniel E Neafsey, Elaine Angelino, Joseph F Cortese, Kayla G Barnes, David M Rosen, Amanda K Lukens, Rachel F Daniels, Danny A Milner, Charles A Johnson, Ilya Shlyakhter, Sharon R Grossman, Justin S Becker, Daniel Yamins, Elinor K Karlsson, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Christian Happi, Nicholas A Furlotte, Eleazar Eskin, Hyun Min Kang, Daniel L Hartl, Bruce W Birren, Roger C Wiegand, Eric S Lander, Dyann F Wirth, Sarah K Volkman, Pardis C Sabeti
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001383 (2011)
The Plasmodium falciparum parasite's ability to adapt to environmental pressures, such as the human immune system and antimalarial drugs, makes malaria an enduring burden to public health. Understanding the genetic basis of these adaptations is criti
Externí odkaz:
https://doaj.org/article/2bcae71e6bc0480f90bbcced935ec106
Autor:
Claire Kidgell, Sarah K Volkman, Johanna Daily, Justin O Borevitz, David Plouffe, Yingyao Zhou, Jeffrey R Johnson, Karine G. Le Roch, Ousmane Sarr, Omar Ndir, Soulyemane Mboup, Serge Batalov, Dyann F Wirth, Elizabeth A Winzeler
Publikováno v:
PLoS Pathogens, Vol 2, Iss 8 (2006)
Externí odkaz:
https://doaj.org/article/abf4c3ab37304e8aa510c2a2dcc35cfe