Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dyana K. Dalton"'
Autor:
Anna Wasiuk, Dyana K. Dalton, William L. Schpero, Jose R. Conejo-Garcia, Randolph J. Noelle, Radu V. Stan
Publikováno v:
Cancer Immunology, Immunotherapy. 61:2273-2282
Mast cells have emerged as critical intermediaries in the regulation of peripheral tolerance. Their presence in many precancerous lesions and tumors is associated with a poor prognosis, suggesting mast cells may promote an immunosuppressive tumor mic
Autor:
Stephen M. Anderton, Dyana K. Dalton, Xujian Li, Randolph J. Noelle, Seth L. Blumerman, Richard A. O’Connor
Publikováno v:
The Journal of Immunology. 188:2093-2101
CFA is a strong adjuvant capable of stimulating cellular immune responses. Paradoxically, adjuvant immunotherapy by prior exposure to CFA or live mycobacteria suppresses the severity of experimental autoimmune encephalomyelitis (EAE) and spontaneous
Publikováno v:
The Journal of Immunology. 179:939-949
Despite many studies, the regulation of CD4+ T cell apoptosis during the shutdown of immune responses is not fully understood. We have investigated the molecular mechanisms of IFN-γ in regulating apoptosis of CD4+ T cells during bacillus Calmette-Gu
Autor:
Susan T. Wittmer, Dyana K. Dalton
Publikováno v:
Journal of Neuroimmunology. 160:110-121
Experimental autoimmune encephalomyelitis (EAE) disease was accelerated iNOS-deficient (KO) mice: coinciding with greatly increased numbers of Ag-specific Th1 cells in the periphery that appeared to rapidly shift from the spleen to the CNS during ons
Publikováno v:
Journal of Autoimmunity. 24:93-100
Infection with Mycobacterium bovis Bacille Calmette Guérin (BCG) induces high levels of apoptosis among activated CD4+ T cells. We have investigated the specificity of this pro-apoptotic response and its influence on CD4+ T cell mediated autoimmunit
Publikováno v:
The Journal of Experimental Medicine
Mice deficient in interferon (IFN)-gamma or IFN-gamma receptor develop progressive and fatal experimental autoimmune encephalomyelitis (EAE). We demonstrate that CD4 T cells lacking IFN-gamma production were required to passively transfer EAE, indica
Publikováno v:
The Journal of Experimental Medicine
In Mycobacterium bovis Bacille Calmette-Guérin (BCG)-infected wild-type mice, there was a large expansion of an activated (CD44(hi)) splenic CD4 T cell population followed by a rapid contraction of this population to normal numbers. Contraction of t
Autor:
Randolph J. Noelle, Dyana K. Dalton
Publikováno v:
Cancer immunology, immunotherapy : CII. 61(9)
The tumor microenvironment (TME), which is composed of stromal cells such as endothelial cells, fibroblasts, and immune cells, provides a supportive niche promoting the growth and invasion of tumors. The TME also raises an immunosuppressive barrier t
Autor:
Karla J. Triebold, Dyana K. Dalton, Barry R. Bloom, John Chan, JoAnne L. Flynn, Timothy A. Stewart
Publikováno v:
The Journal of Experimental Medicine
Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries. The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T
Autor:
Ian M. Orme, Andrea M. Cooper, J P Griffin, David G. Russell, Dyana K. Dalton, Timothy A. Stewart
Publikováno v:
The Journal of Experimental Medicine
The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by T lymphocytes that secrete cytokines. These molecules then mediate a variety of roles, including the activation of parasitized host macrophages, and the recrui