Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Dwight V. Nissley"'
Autor:
Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract RAF kinases are integral to the RAS-MAPK signaling pathway, and proper RAF1 folding relies on its interaction with the chaperone HSP90 and the cochaperone CDC37. Understanding the intricate molecular interactions governing RAF1 folding is cr
Externí odkaz:
https://doaj.org/article/e615e38499a94c368dff4f9a7c76932e
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS initiates MAPK signaling with RAF effecto
Externí odkaz:
https://doaj.org/article/c9c372b885d34294a1a4b151fe83ce95
Autor:
Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for designing inhibitors. Among several o
Externí odkaz:
https://doaj.org/article/69321b8535d54b5689b2d175700764dc
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ebd31f95883b42a68c6081c546cb6fe3
Autor:
Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick, Dhirendra K. Simanshu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and pro
Externí odkaz:
https://doaj.org/article/8075c5993bfb4f61bc8bb5d453321337
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103608- (2022)
Summary: Understanding the spatiotemporal distribution and dynamics of RAS on the plasma membrane (PM) is the key for elucidating the molecular mechanisms of the RAS signaling pathway. Single particle tracking (SPT) experiments show that in cells, KR
Externí odkaz:
https://doaj.org/article/b2082f6fe93940f0966c6fc4a2000b8a
Autor:
Helgi I. Ingólfsson, Harsh Bhatia, Fikret Aydin, Tomas Oppelstrup, Cesar A. López, Liam G. Stanton, Timothy S. Carpenter, Sergio Wong, Francesco Di Natale, Xiaohua Zhang, Joseph Y. Moon, Christopher B. Stanley, Joseph R. Chavez, Kien Nguyen, Gautham Dharuman, Violetta Burns, Rebika Shrestha, Debanjan Goswami, Gulcin Gulten, Que N. Van, Arvind Ramanathan, Brian Van Essen, Nicolas W. Hengartner, Andrew G. Stephen, Thomas Turbyville, Peer-Timo Bremer, S. Gnanakaran, James N. Glosli, Felice C. Lightstone, Dwight V. Nissley, Frederick H. Streitz
Publikováno v:
Journal of Chemical Theory and Computation. 19:2658-2675
Autor:
Debanjan Goswami, De Chen, Yue Yang, Prabhakar R Gudla, John Columbus, Karen Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell, William Burgan, Vanessa Wall, Dominic Esposito, Dhirendra K Simanshu, Felice C Lightstone, Dwight V Nissley, Frank McCormick, Thomas Turbyville
Publikováno v:
eLife, Vol 9 (2020)
The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-dom
Externí odkaz:
https://doaj.org/article/c798200b000d4c1ab8ba16fab0ce9c68
Autor:
Cesar A. López, Xiaohua Zhang, Fikret Aydin, Rebika Shrestha, Que N. Van, Christopher B. Stanley, Timothy S. Carpenter, Kien Nguyen, Lara A. Patel, De Chen, Violetta Burns, Nicolas W. Hengartner, Tyler J. E. Reddy, Harsh Bhatia, Francesco Di Natale, Timothy H. Tran, Albert H. Chan, Dhirendra K. Simanshu, Dwight V. Nissley, Frederick H. Streitz, Andrew G. Stephen, Thomas J. Turbyville, Felice C. Lightstone, Sandrasegaram Gnanakaran, Helgi I. Ingólfsson, Chris Neale
Publikováno v:
Journal of Chemical Theory and Computation. 18:5025-5045
The appeal of multiscale modeling approaches is predicated on the promise of combinatorial synergy. However, this promise can only be realized when distinct scales are combined with reciprocal consistency. Here, we consider multiscale molecular dynam
Autor:
Frank McCormick, Dwight V. Nissley, Serguei V. Kozlov, Theresa M. Guerin, Ming Yi, William Burgan, Pavan P. Adiseshaiah, Debanjan Goswami, Suman Mukhopadhyay
Metabolic Pathway Enrichment in PDAC Patients Treated with Gemcitabine (Data Pooled from TCGA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a53c39d6003072e7883ee7a58d93261
https://doi.org/10.1158/0008-5472.22424965.v1
https://doi.org/10.1158/0008-5472.22424965.v1