Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Dwight Stambolian"'
Autor:
Anthony M. Musolf, Annechien E. G. Haarman, Robert N. Luben, Jue-Sheng Ong, Karina Patasova, Rolando Hernandez Trapero, Joseph Marsh, Ishika Jain, Riya Jain, Paul Zhiping Wang, Deyana D. Lewis, Milly S. Tedja, Adriana I. Iglesias, Hengtong Li, Cameron S. Cowan, Consortium for Refractive Error and Myopia (CREAM), Ginevra Biino, Alison P. Klein, Priya Duggal, David A. Mackey, Caroline Hayward, Toomas Haller, Andres Metspalu, Juho Wedenoja, Olavi Pärssinen, Ching-Yu Cheng, Seang-Mei Saw, Dwight Stambolian, Pirro G. Hysi, Anthony P. Khawaja, Veronique Vitart, Christopher J. Hammond, Cornelia M. van Duijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
A multi-ethnic meta-analysis of exome array data from over 27,000 participants identifies several rare variants that could contribute to risk of ocular refractive error.
Externí odkaz:
https://doaj.org/article/bd8c4caa72a641eab1075fd26afb62da
Autor:
Treefa Shwani, Charles Zhang, Leah A. Owen, Akbar Shakoor, Albert T. Vitale, John H. Lillvis, Julie L. Barr, Parker Cromwell, Robert Finley, Nadine Husami, Elizabeth Au, Rylee A. Zavala, Elijah C. Graves, Sarah X. Zhang, Michael H. Farkas, David A. Ammar, Karen M. Allison, Amany Tawfik, Richard M. Sherva, Mingyao Li, Dwight Stambolian, Ivana K. Kim, Lindsay A. Farrer, Margaret M. DeAngelis
Publikováno v:
Cells, Vol 12, Iss 23, p 2668 (2023)
Age-related macular degeneration (AMD) is a leading cause of blindness, and elucidating its underlying disease mechanisms is vital to the development of appropriate therapeutics. We identified differentially expressed genes (DEGs) and differentially
Externí odkaz:
https://doaj.org/article/e8beab75624a4f28ace7d19d17448129
Autor:
Yafei Lyu, Randy Zauhar, Nicholas Dana, Christianne E. Strang, Jian Hu, Kui Wang, Shanrun Liu, Naifei Pan, Paul Gamlin, James A. Kimble, Jeffrey D. Messinger, Christine A. Curcio, Dwight Stambolian, Mingyao Li
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Age‐related macular degeneration (AMD) is a blinding eye disease with no unifying theme for its etiology. We used single-cell RNA sequencing to analyze the transcriptomes of ~ 93,000 cells from the macula and peripheral retina from two adu
Externí odkaz:
https://doaj.org/article/1fb14e76067840689b61cd1fd4222f8f
Autor:
Randy Zauhar, Josef Biber, Yassin Jabri, Mijin Kim, Jian Hu, Lew Kaplan, Anna M. Pfaller, Nicole Schäfer, Volker Enzmann, Ursula Schlötzer-Schrehardt, Tobias Straub, Stefanie M. Hauck, Paul D. Gamlin, Michael B. McFerrin, Jeffrey Messinger, Christianne E. Strang, Christine A. Curcio, Nicholas Dana, Diana Pauly, Antje Grosche, Mingyao Li, Dwight Stambolian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The cellular events that dictate the initiation of the complement pathway in ocular degeneration, such as age-related macular degeneration (AMD), is poorly understood. Using gene expression analysis (single cell and bulk), mass spectrometry, and immu
Externí odkaz:
https://doaj.org/article/363b337912ce45b19bb94aaf179cc4b0
Autor:
Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R.M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110942- (2022)
Summary: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron in AMD, and iron overl
Externí odkaz:
https://doaj.org/article/a701cd56ed6f48bc9d2e45ba3c34f5f4
Autor:
Nadav Rakocz, Jeffrey N. Chiang, Muneeswar G. Nittala, Giulia Corradetti, Liran Tiosano, Swetha Velaga, Michael Thompson, Brian L. Hill, Sriram Sankararaman, Jonathan L. Haines, Margaret A. Pericak-Vance, Dwight Stambolian, Srinivas R. Sadda, Eran Halperin
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-13 (2021)
Abstract One of the core challenges in applying machine learning and artificial intelligence to medicine is the limited availability of annotated medical data. Unlike in other applications of machine learning, where an abundance of labeled data is av
Externí odkaz:
https://doaj.org/article/db547242a9544aa0933b586e70820352
Autor:
Xiangjie Li, Kui Wang, Yafei Lyu, Huize Pan, Jingxiao Zhang, Dwight Stambolian, Katalin Susztak, Muredach P. Reilly, Gang Hu, Mingyao Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Increasingly large scRNA-seq datasets demand better and more scalable analysis tools. Here, the authors introduce a scalable unsupervised deep embedding algorithm that clusters scRNA-seq data by iteratively optimizing a clustering objective function
Externí odkaz:
https://doaj.org/article/d25ce1857e63443bb60277874e79ad11
Autor:
Muneeswar G. Nittala, Federico Corvi, Jyotsna Maram, Swetha B. Velaga, Jonathan Haines, Margaret A. Pericak-Vance, Dwight Stambolian, SriniVas R. Sadda
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 17, p 5110 (2022)
Objective: To evaluate the optical coherence tomography (OCT)-based risk factors for progression to late age-related macular degeneration (AMD) in a population-based study of elderly Amish. Methods: A total of 1332 eyes of 666 consecutive subjects wh
Externí odkaz:
https://doaj.org/article/292fea3559e6465cac6b204f86d3f72a
Autor:
Claire L. Simpson, Anthony M. Musolf, Qing Li, Laura Portas, Federico Murgia, Roberto Y. Cordero, Jennifer B. Cordero, Bilal A. Moiz, Emily R. Holzinger, Candace D. Middlebrooks, Deyana D. Lewis, Joan E. Bailey-Wilson, Dwight Stambolian
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Myopia is one of most common eye diseases in the world and affects 1 in 4 Americans. It is a complex disease caused by both environmental and genetics effects; the genetics effects are still not well understood. In this study, we
Externí odkaz:
https://doaj.org/article/2cf6d5d12b7e43948f247492dabbc56b
Autor:
Diana Pauly, Divyansh Agarwal, Nicholas Dana, Nicole Schäfer, Josef Biber, Kirsten A. Wunderlich, Yassin Jabri, Tobias Straub, Nancy R. Zhang, Avneesh K. Gautam, Bernhard H.F. Weber, Stefanie M. Hauck, Mijin Kim, Christine A. Curcio, Dwight Stambolian, Mingyao Li, Antje Grosche
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2835-2848.e4 (2019)
Summary: Complement dysregulation is a feature of many retinal diseases, yet mechanistic understanding at the cellular level is limited. Given this knowledge gap about which retinal cells express complement, we performed single-cell RNA sequencing on
Externí odkaz:
https://doaj.org/article/bac62f836d3541a2a490fbcf404c3aeb