Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Dwight, MacDonald"'
Autor:
Loes M. Stevers, Madita Wolter, Graeme W. Carlile, Dwight Macdonald, Luc Richard, Frank Gielkens, John W. Hanrahan, David Y. Thomas, Sai Kumar Chakka, Mark L. Peterson, Helmut Thomas, Luc Brunsveld, Christian Ottmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Mutations in the chloride channel CFTR that impair plasma membrane insertion and ion transport are the cause of cystic fibrosis. Here, the authors identify a macrocycle that stabilizes the interaction of mutant CFTR with the chaperone-like protein 14
Externí odkaz:
https://doaj.org/article/92fd952667d14a1ba9705d63a6a37de1
Autor:
Dwight Macdonald
Thirty years since it was first published, Macdonald's masterful book on the Ford Foundation remains the only book-length account of this institution that has been published. Despite the calls for a book carrying on the story from 1956 on the part of
Autor:
Dwight Macdonald
Publikováno v:
Notions of Genre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1031ee42dba4302796d1d50697cd3efe
https://doi.org/10.7560/303757-006
https://doi.org/10.7560/303757-006
Autor:
Sébastien Gagné, Amandine Chefson, Sylvie Toulmond, Patrick Lacombe, Mélissa Arbour, Austin Chen, Dan McKay, Elizabeth Cauchon, Erich L. Grimm, Yeeman K. Ramtohul, M. David Percival, Jean-François Lévesque, Yves Ducharme, Dwight Macdonald, Yongxin Han, René St-Jacques, Robert Houle, Bruce Mackay, Jean-Pierre Falgueyret, Pierre-André Fournier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2670-2674
The design and optimization of a novel isoxazole S(1) linker for renin inhibitor is described herein. This effort culminated in the identification of compound 18, an orally bioavailable, sub-nanomolar renin inhibitor even in the presence of human pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb21bf0f8aa1b021cd6fbd529e12bdc
https://doi.org/10.1016/j.bmcl.2012.03.014
https://doi.org/10.1016/j.bmcl.2012.03.014
Autor:
Kelly Bleasby, Dwight Macdonald, Bruce Mackay, Richard Tschirret-Guth, Robert Houle, Sebastien Laliberte, Patrick Lacombe, Robert Papp, Erich L. Grimm, Amandine Chefson, Jean-François Lévesque, Michael J. Hafey, Pierre-André Fournier, Sébastien Gagné, Yongxin Han, Yves Ducharme, Michel Gallant, Austin Chen, Daniel Dube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5547-5551
An oral bioavailability issue encountered during the course of lead optimization in the renin program is described herein. The low F(po) of pyridone analogs was shown to be caused by a combination of poor passive permeability and gut efflux transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b390428a9f09b127996a8190fb39ae
https://doi.org/10.1016/j.bmcl.2011.06.095
https://doi.org/10.1016/j.bmcl.2011.06.095
Autor:
Stephen M. Soisson, Tom Y.-H. Wu, Michel Gallant, Austin Chen, Dwight Macdonald, Daniel Dube, Robert Houle, Jean-Pierre Falgueyret, Renee Aspiotis, Dan McKay, Jean-François Lévesque, Patrick Roy, Helene Juteau, Sébastien Gagné, M. David Percival, Erich L. Grimm, Sebastien Laliberte, Patrick Lacombe, Elizabeth Cauchon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2430-2436
The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5869451b5d4a9f35f5a8af8a027ba80
https://doi.org/10.1016/j.bmcl.2011.02.067
https://doi.org/10.1016/j.bmcl.2011.02.067
Autor:
F. Otu, Joseph A. Mancini, Dwight Macdonald, Rebecca Dias, Daniel Dube, L. Zhang, Patrick Lacombe, Pascal Jean Denis Goetghebeur, Angela Styhler, David Claveau, Suzanna Liu, Yves Girard, Zheng Huang, Mervyn J. Turner, Michel Gallant, William M. Abraham, K. Ng, Thomas R. Jones, F. Laliberte, Robert N. Young, Donald W. Nicholson
Publikováno v:
Biochemical Pharmacology. 73:1971-1981
Type 4 phosphodiesterases (PDE4) inhibitors are emerging therapeutics in the treatment of a number of chronic disorders including asthma, chronic obstructive pulmonary disease (COPD) and cognitive disorders. This study delineates the preclinical prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2765f56857f1438d13b1b2fb56afa4fc
https://doi.org/10.1016/j.bcp.2007.03.010
https://doi.org/10.1016/j.bcp.2007.03.010
Autor:
Yves Girard, Dwight Macdonald, Deborah A. Nicoll-Griffith, Michel Gallant, Nathalie Chauret, Daniel Dube, Anthony Mastracchio, Laird A. Trimble, Kevin P. Bateman, José M. Silva, Stephen Day, Helene Perrier
Publikováno v:
Journal of Mass Spectrometry. 41:771-780
L-454,560 is a potent phospodiesterase 4 (PDE4) inhibitor which was identified as a development candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). As part of the discovery of this compound, interspecies in vitro m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1928b6590a4e2d0d6824c8c9bf46cf74
https://doi.org/10.1002/jms.1033
https://doi.org/10.1002/jms.1033
Autor:
Dwight Macdonald, Antoinette Drahus-Paone, Roy Helmy, Denis Deschenes, Guo-Jie Ho, John Scheigetz, James M. McNamara, Brenda Pipik, Yao-Jun Shi, David A. Conlon, Michel Gallant, Bruno Roy, J. Michael Williams, Anthony Mastracchio
Publikováno v:
Organic Process Research & Development. 10:36-45
An efficient, scalable synthesis of the PDE4 inhibitor, 6-[1-methyl-1-(methylsulfonyl)ethyl]-8-(3-{(E)-2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-[4-(methylsulfonyl)phenyl]vinyl}phenyl)quinoline benzenesu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0e5ea4b5cc94d87e173aec7aa586840
https://doi.org/10.1021/op050116l
https://doi.org/10.1021/op050116l