Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Dwayne G, Stupack"'
Autor:
Ruifang Gao, Yanhua Liu, Dan Li, Jing Xun, Wei Zhou, Peng Wang, Chen Liu, Xiru Li, Wenzhi Shen, Weijun Su, Huan Qiao, Dwayne G. Stupack, Na Luo
Publikováno v:
Cellular Physiology and Biochemistry, Vol 50, Iss 6, Pp 2108-2123 (2018)
Background/Aims: The bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 (PFKFB4) is highly expressed in many types of cancer and its requirement for tumor survival has been demonstrated in glioma, lung, and prostate cancers.
Externí odkaz:
https://doaj.org/article/c1a872caf7b240b0a418c692ee4f2a5e
Autor:
Joe Ryan Delaney, Chandni B. Patel, Katelyn McCabe Willis, Mina Haghighiabyaneh, Joshua Axelrod, Isabelle Tancioni, Dan Lu, Jaidev Bapat, Shanique Young, Octavia Cadassou, Alena Bartakova, Parthiv Sheth, Carley Haft, Sandra Hui, Cheryl Saenz, David D. Schlaepfer, Olivier Harismendy, Dwayne G. Stupack
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Cancers accumulate multiple single copy number alterations, but their impact is unclear. Here, the authors computationally demonstrate a disruption of genes associated with autophagy in ovarian cancer, show impact on autophagic flux, and note the eff
Externí odkaz:
https://doaj.org/article/4693ab4669b34978ad4a226632a7b4a7
Autor:
Joe R Delaney, Chandni B Patel, Jaidev Bapat, Christian M Jones, Maria Ramos-Zapatero, Katherine K Ortell, Ralph Tanios, Mina Haghighiabyaneh, Joshua Axelrod, John W DeStefano, Isabelle Tancioni, David D Schlaepfer, Olivier Harismendy, Albert R La Spada, Dwayne G Stupack
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008558 (2020)
Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is com
Externí odkaz:
https://doaj.org/article/f42e584000f74e659bc9e24835d7c355
Autor:
Carlos J Diaz Osterman, Duygu Ozmadenci, Elizabeth G Kleinschmidt, Kristin N Taylor, Allison M Barrie, Shulin Jiang, Lisa M Bean, Florian J Sulzmaier, Christine Jean, Isabelle Tancioni, Kristen Anderson, Sean Uryu, Edward A Cordasco, Jian Li, Xiao Lei Chen, Guo Fu, Marjaana Ojalill, Pekka Rappu, Jyrki Heino, Adam M Mark, Guorong Xu, Kathleen M Fisch, Vihren N Kolev, David T Weaver, Jonathan A Pachter, Balázs Győrffy, Michael T McHale, Denise C Connolly, Alfredo Molinolo, Dwayne G Stupack, David D Schlaepfer
Publikováno v:
eLife, Vol 8 (2019)
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities,
Externí odkaz:
https://doaj.org/article/7193db572cdc40948c8a07915a6afd96
Publikováno v:
Nature Reviews Cancer. 22:437-451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c419ed01de06e9b7c78cf7224faa065
https://doi.org/10.1038/s41568-022-00481-2
https://doi.org/10.1038/s41568-022-00481-2
Autor:
Dwayne G. Stupack, David Schlaepfer, Jill M. Lahti, Daniela Barilà, Matthew Bogyo, David Mikolon, David J. Shields, Tal Teitz, Vicente Torres, Ainhoa Mielgo, Simone Barbero
Supplementary Figures 1-5 from Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2156c4984120c33221dec024c9ea71d9
https://doi.org/10.1158/0008-5472.22380269.v1
https://doi.org/10.1158/0008-5472.22380269.v1
Autor:
Rong Xiang, Ralph A. Reisfeld, Dwayne G. Stupack, Ze Liu, Zongjin Li, Chenghu Liu, Na Li, Xiaoyue Tan, Si Chen, Dan Lu
PDF file - 2.1MB, Human breast cancer cells were treated with CTX (500uM) for 24hrs and the apoptosis were evaluated by Annexin V and PI double staining (A). Fra-1 expression in these breast cancer cells were detected by Western-blot (B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7b2e0aeb66293dc44f26fa36af0946
https://doi.org/10.1158/0008-5472.22393310
https://doi.org/10.1158/0008-5472.22393310
Autor:
Dwayne G. Stupack, David Schlaepfer, Jill M. Lahti, Daniela Barilà, Matthew Bogyo, David Mikolon, David J. Shields, Tal Teitz, Vicente Torres, Ainhoa Mielgo, Simone Barbero
Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d922643cc33627dcebaea2a62885ce7c
https://doi.org/10.1158/0008-5472.c.6499511.v1
https://doi.org/10.1158/0008-5472.c.6499511.v1
Autor:
Rong Xiang, Ralph A. Reisfeld, Dwayne G. Stupack, Ze Liu, Zongjin Li, Chenghu Liu, Na Li, Xiaoyue Tan, Si Chen, Dan Lu
PDF file - 56K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d0c75a21560dfe253a2316f7fb88ac
https://doi.org/10.1158/0008-5472.22393298.v1
https://doi.org/10.1158/0008-5472.22393298.v1
Autor:
Rong Xiang, Ralph A. Reisfeld, Dwayne G. Stupack, Ze Liu, Zongjin Li, Chenghu Liu, Na Li, Xiaoyue Tan, Si Chen, Dan Lu
PDF file - 4.2MB, Final tumor burden was depicted as size(A) and weight(B) on Day 23 after harvest, and the expression of Fra-1 in these tumors was further confirmed by western-blot(C)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12675073072c5138a0c23b19703bf93d
https://doi.org/10.1158/0008-5472.22393301.v1
https://doi.org/10.1158/0008-5472.22393301.v1