CELLULAR RNA INTERACTS WITH MAVS TO PROMOTE ANTIVIRAL SIGNALING.

Autor: Gokhale NS; Department of Immunology, University of Washington, Seattle, WA., Somfleth K; Department of Immunology, University of Washington, Seattle, WA., Thompson MG; Department of Integrative Immunobiology, Duke University, Durham, NC., Sam RK; Department of Immunology, University of Washington, Seattle, WA., Marciniak DM; Department of Pharmacology, University of Washington, Seattle, WA., Chu LH; Department of Immunology, University of Washington, Seattle, WA., Park M; Department of Integrative Immunobiology, Duke University, Durham, NC., Dvorkin S; Department of Immunology, University of Washington, Seattle, WA., Oberst A; Department of Immunology, University of Washington, Seattle, WA., Horner SM; Department of Integrative Immunobiology, Duke University, Durham, NC.; Department of Medicine, Duke University, Durham NC., Ong SE; Department of Pharmacology, University of Washington, Seattle, WA., Gale M Jr; Department of Immunology, University of Washington, Seattle, WA., Savan R; Department of Immunology, University of Washington, Seattle, WA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 25. Date of Electronic Publication: 2023 Sep 25.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant.

Autor: Gray LT; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Raczy MM; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Briquez PS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Marchell TM; Committee on Immunology, University of Chicago, Chicago, IL, 60637, United States., Alpar AT; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Wallace RP; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Volpatti LR; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Sasso MS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Cao S; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Nguyen M; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Mansurov A; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Budina E; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Watkins EA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Solanki A; Animal Resources Center, University of Chicago, Chicago, IL, 60637, United States., Mitrousis N; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Reda JW; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Yu SS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Tremain AC; Committee on Immunology, University of Chicago, Chicago, IL, 60637, United States., Wang R; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Nicolaescu V; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL, 60637, United States., Furlong K; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL, 60637, United States., Dvorkin S; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL, 60637, United States., Manicassamy B; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, 52242, United States., Randall G; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL, 60637, United States., Wilson DS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, 21231, United States., Kwissa M; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States., Swartz MA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States; Committee on Immunology, University of Chicago, Chicago, IL, 60637, United States; Committee on Cancer Biology, University of Chicago, Chicago, IL, 60637, United States; Ben May Department of Cancer Research, University of Chicago, Chicago, IL, 60637, United States. Electronic address: melodyswartz@uchicago.edu., Hubbell JA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, 60637, United States; Committee on Immunology, University of Chicago, Chicago, IL, 60637, United States; Committee on Cancer Biology, University of Chicago, Chicago, IL, 60637, United States. Electronic address: jhubbell@uchicago.edu.

Publikováno v: Biomaterials [Biomaterials] 2021 Nov; Vol. 278, pp. 121159. Date of Electronic Publication: 2021 Sep 30.

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

Autor: Drayman N; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA. tays@uchicago.edu nirdra@uchicago.edu., DeMarco JK; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA., Jones KA; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA., Azizi SA; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA., Froggatt HM; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA., Tan K; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA., Maltseva NI; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA., Chen S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Cellular Screening Center, The University of Chicago, Chicago, IL, USA., Nicolaescu V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA., Dvorkin S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA., Furlong K; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA., Kathayat RS; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA., Firpo MR; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Mastrodomenico V; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Bruce EA; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Schmidt MM; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Jedrzejczak R; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA., Muñoz-Alía MÁ; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA., Schuster B; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA., Nair V; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA., Han KY; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.; Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., O'Brien A; Department of Pharmaceutical Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Tomatsidou A; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA., Meyer B; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France., Vignuzzi M; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France., Missiakas D; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA., Botten JW; Cellular Screening Center, The University of Chicago, Chicago, IL, USA.; Department of Medicine, Division of Immunobiology, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA., Brooke CB; Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Lee H; Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, Biophysics Core at Research Resources Center, University of Illinois at Chicago, Chicago, IL, USA., Baker SC; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Mounce BC; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA., Heaton NS; Institut Pasteur, Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Paris, France.; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA., Severson WE; Department of Chemistry, The University of Chicago, Chicago, IL, USA.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA., Palmer KE; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA., Dickinson BC; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA.; Department of Chemistry, The University of Chicago, Chicago, IL, USA., Joachimiak A; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL, USA.; Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, IL, USA.; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA., Randall G; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA., Tay S; Department of Microbiology, Ricketts Laboratory, University of Chicago, Chicago, IL, USA. tays@uchicago.edu nirdra@uchicago.edu.; Pritzker School for Molecular Engineering, The University of Chicago, Chicago, IL, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Aug 20; Vol. 373 (6557), pp. 931-936. Date of Electronic Publication: 2021 Jul 20.

Maintenance of the human memory T cell repertoire by subset and tissue site.

Autor: Miron M; Department of Microbiology and Immunology, Columbia University, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University, New York, NY, USA., Meng W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rosenfeld AM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dvorkin S; Department of Mathematics, Bar Ilan University, Ramat Gan, Israel., Poon MML; Department of Microbiology and Immunology, Columbia University, New York, NY, USA., Lam N; Department of Microbiology and Immunology, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA., Kumar BV; Columbia Center for Translational Immunology, Columbia University, New York, NY, USA., Louzoun Y; Department of Mathematics, Bar Ilan University, Ramat Gan, Israel., Luning Prak ET; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. luning@pennmedicine.upenn.edu., Farber DL; Department of Microbiology and Immunology, Columbia University, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Surgery, Columbia University, New York, NY, USA. df2396@cumc.columbia.edu.

Publikováno v: Genome medicine [Genome Med] 2021 Jun 14; Vol. 13 (1), pp. 100. Date of Electronic Publication: 2021 Jun 14.

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity.

Autor: Volpatti LR; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Wallace RP; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Cao S; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Raczy MM; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Wang R; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Gray LT; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Alpar AT; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Briquez PS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Mitrousis N; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Marchell TM; Committee on Immunology, University of Chicago, Chicago, IL 60637, United States., Sasso MS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Nguyen M; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Mansurov A; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Budina E; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Solanki A; Animal Resources Center, University of Chicago, Chicago, IL 60637, United States., Watkins EA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Schnorenberg MR; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Tremain AC; Committee on Immunology, University of Chicago, Chicago, IL 60637, United States., Reda JW; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Nicolaescu V; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States., Furlong K; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States., Dvorkin S; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States., Yu SS; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Manicassamy B; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, United States., LaBelle JL; Department of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, IL 60637, United States., Tirrell MV; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Materials Science Division, Argonne National Laboratory, Lemont, IL 60439, United States., Randall G; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States., Kwissa M; Department of Microbiology, Howard T. Ricketts Laboratory, University of Chicago, Chicago, IL 60637, United States.; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States., Swartz MA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Committee on Immunology, University of Chicago, Chicago, IL 60637, United States.; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, United States.; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, United States., Hubbell JA; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, United States.; Committee on Immunology, University of Chicago, Chicago, IL 60637, United States.; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Apr 08. Date of Electronic Publication: 2021 Apr 08.