Exoproteomic analysis of two MLST clade 2 strains of Clostridioides difficile from Latin America reveal close similarities

Autor: John R. Barr, Carlos Quesada-Gómez, Eliane de Oliveira Ferreira, Regina Maria Cavalcanti Pilotto Domingues, Cecília Leite Costa, Gerly Anne de Castro Brito, Glauber Wagner, Guilherme Augusto Maia, Renato Simões Moreira, Dvison M. Pacífico, Vilmar Benetti Filho, Hercules Moura

Publikováno v: Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports

Clostridioides difficile BI/NAP1/ribotype 027 is an epidemic hypervirulent strain found worldwide, including in Latin America. We examined the genomes and exoproteomes of two multilocus sequence type (MLST) clade 2 C. difficile strains considered hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fc213bdfd6e3b9ac997f94c641c5de
http://www.repositorio.ufc.br/handle/riufc/63276

H2S is a key antisecretory molecule against cholera toxin-induced diarrhoea in mice: Evidence for non-involvement of the AC/cAMP/PKA pathway and AMPK

Autor: Jand Venes R. Medeiros, Francisca Beatriz M. Sousa, Thiago S.L. Araújo, Jefferson Soares de Oliveira, Luan Kelves Miranda de Souza, Simone de Araújo, Marcellus H.L.P. Souza, Lucas A.D. Nicolau, Dvison M. Pacífico, Fabiana de Moura Souza, Marcelo de Carvalho Filgueiras, Renan O. Silva, Nayara A. Sousa, Irismara Sousa Silva

Publikováno v: Nitric Oxide. 76:152-163

Hydrogen sulphide (H2S) is a gasotransmitter that participates in various physiological and pathophysiological processes within the gastrointestinal tract. We studied the effects and possible mechanism of action of H2S in secretory diarrhoea caused b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61c9fcf16e6e4e49788047f6995aef6e
https://doi.org/10.1016/j.niox.2017.09.007

Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis

Autor: Kerolayne M. Nogueira, Luan Kelves Miranda de Souza, Simone de Araújo, Conceição da Silva Martins, Ana Patrícia de Oliveira, Dvison M. Pacífico, Renan O. Silva, Gerly Anne de Castro Brito, Marcellus H.L.P. Souza, Francisca Beatriz M. Sousa, Thiago S.L. Araújo, Jand Venes R. Medeiros

Publikováno v: Nutrients, Vol 11, Iss 1, p 208 (2019)
Nutrients
Volume 11
Issue 1

This study aimed to evaluate the effect of Lactobacillus reuteri DSM 17938 (DSM) on ethanol-induced gastric injury, and if its possible mechanism of action is related to inhibiting the transient receptor potential vanilloid type 1 (TRPV1). We evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b29106f39d1d175e3fa657246e37c43
https://www.mdpi.com/2072-6643/11/1/208

Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice

Autor: Bruno Iles, Damião Pergentino de Sousa, Simone de Araújo, José Lopes Pereira Júnior, Elenice Monte Alvarenga, Gerly Anne de Castro Brito, Nayara A. Sousa, Dvison M. Pacífico, Alyne Rodrigues de Araújo, Emmanuel P. Souza, Jand Venes R. Medeiros

Publikováno v: The Journal of pharmacy and pharmacology. 69(12)

Objectives We aimed to determine whether carvacryl acetate acts as a TRPA1 receptor agonist and its effects against irinotecan (CPT-11) induced intestinal mucositis in mice. Methods TRPA1 structure was obtained from a protein databank, and the 3D str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e706015375a40038e8e81920e7badfe
https://pubmed.ncbi.nlm.nih.gov/28940490

Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation

Autor: Thiago S.L. Araújo, Elenice Monte Alvarenga, Luan Kelves Miranda de Souza, Alyne Rodrigues de Araújo, Dvison M. Pacífico, Damião Pergentino de Sousa, Gerly Anne de Castro Brito, Jand Venes R. Medeiros, Conceição da Silva Martins, Francisca Beatriz M. Sousa, Kerolayne M. Nogueira, Emmanuel P. Souza

Publikováno v: Chemico-biological interactions. 260

Intestinal mucositis is an inflammatory process occurring in the intestinal mucosa and is a common side effect of irinotecan hydrochloride (CPT-11) based anticancer regimens. The transient receptor potential cation channel, subfamily A, member 1 (TRP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b0d85df1076e45dbae39c2c8f01d73
https://pubmed.ncbi.nlm.nih.gov/27838229