Multi-dimensional immunoproteomics coupled with in vitro recapitulation of oncogenic NRAS ^Q61R identifies diagnostically relevant autoantibody biomarkers in thyroid neoplasia.

Autor: Belousov PV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. Electronic address: belousp@gmail.com., Afanasyeva MA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Gubernatorova EO; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, Russia., Bogolyubova AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Center for Genetics and Life Sciences, Educational Center «Sirius», Sochi, Russia., Uvarova AN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Putlyaeva LV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia., Ramanauskaite EM; Biological Faculty, Lomonosov Moscow State University, Moscow, Russia., Kopylov AT; Institute of Biomedical Chemistry, Moscow, Russia., Demin DE; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, Moscow, Russia., Tatosyan KA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Ustiugova AS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, Russia., Prokofjeva MM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Lanshchakov KV; National Medical Research Center for Endocrinology, Ministry of Health of the Russian Federation, Moscow, Russia; Central Clinical Hospital of the Presidential Administration of the Russian Federation, Moscow, Russia., Vanushko VE; National Medical Research Center for Endocrinology, Ministry of Health of the Russian Federation, Moscow, Russia., Zaretsky AR; Shemyakin-Ovchinnikov Research Institute for Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Evrogen Lab LLC, Moscow, Russia., Severskaia NV; Tsyb Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Dvinskikh NY; Tsyb Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Abrosimov AY; National Medical Research Center for Endocrinology, Ministry of Health of the Russian Federation, Moscow, Russia; National University of Science & Technology «MISIS», Moscow, Russia., Kuprash DV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Biological Faculty, Lomonosov Moscow State University, Moscow, Russia., Schwartz AM; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Publikováno v: Cancer letters [Cancer Lett] 2019 Dec 28; Vol. 467, pp. 96-106. Date of Electronic Publication: 2019 Jul 18.

Serum Immunoproteomics Combined With Pathological Reassessment of Surgical Specimens Identifies TCP-1ζ Autoantibody as a Potential Biomarker in Thyroid Neoplasia.

Autor: Belousov PV; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Bogolyubova AV; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Kim YS; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Abrosimov AY; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Kopylov AT; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Tvardovskiy AA; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Lanshchakov KV; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Sazykin AY; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Dvinskikh NY; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Bobrovskaya YI; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Selivanova LS; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Shilov ES; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Schwartz AM; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Shebzukhov YV; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Severskaia NV; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Vanushko VE; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Moshkovskii SA; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Nedospasov SA; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia., Kuprash DV; Department of Immunology (P.V.B., A.V.B., Y.S.K., A.Y.S., Y.I.B., E.S.S., S.A.N., D.V.K.) Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia; Laboratory of Molecular Mechanisms of Immunity (A.V.B., S.A.N.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Department of Pathomorphology (A.Y.A., L.S.S.), Endocrinology Research Center, 117036 Moscow, Russia; Acousto-Optical Research Center (A.Y.A.), National University of Science & Technology 'MISIS,' 119049 Moscow, Russia; Laboratory of Systems Biology (A.T.K.), Institute of Biomedical Chemistry, 119121 Moscow, Russia; Department of Molecular Immunology (A.A.T., S.A.N.), A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Department of Surgery (K.V.L., V.E.V.), Endocrinology Research Center, 117036 Moscow, Russia; Medical Radiology Research Center (N.Y.D., N.V.S.), 249036 Obninsk, Russia; Laboratory of Intracellular Signaling in Health and Disease (A.M.S., D.V.K.), Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; German Rheumatism Research Center (Y.V.S., S.A.N.), a Leibniz Institute, 10117 Berlin, Germany; and Laboratory of Personalized Medicine (S.A.M.), Institute of Biomedical Chemistry, 119121 Moscow, Russia.

Publikováno v: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2015 Sep; Vol. 100 (9), pp. E1206-15. Date of Electronic Publication: 2015 Jul 21.