Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Duyvesteyn HME"'
Autor:
Julia A. Tree, Tomas Malinauskas, Mark Howarth, Adrian K. Zagrajek, Veronica Martini, John W. McCauley, Ryan Waters, Jiandong Huo, Jane C. Edwards, Ginette Wilsden, Holly Shelton, Alison Burman, Anna B. Ludi, Rolle Rahikainen, Rod S. Daniels, Isabelle Dietrich, Huang K-Ya., David I. Stuart, Simon P. Graham, M. Pedrera, Valerie Mioulet, Raymond J. Owens, Christopher Chiu, Pramila Rijal, Nazia Thakur, Philippa Hollinghurst, Sushant Bhat, Hayes Jwp., Matthew Tully, Alain Townsend, Miles W. Carroll, Saira Hussain, Clare Browning, Tobias J. Tuthill, Tiong Kit Tan, Katy Moffat, Dagmara Bialy, Rebecca K. McLean, Elma Tchilian, Karen R. Buttigieg, Sylvia Crossley, Ashley R. Gray, Carina Conceicao, Joseph Newman, Phoebe Stevenson-Leggett, Ruth Harvey, Bryan Charleston, Mehreen Azhar, Dalan Bailey, Amin S. Asfor, Duyvesteyn Hme., Anthony H. Keeble, John A. Hammond, Lisa Schimanski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. The vaccine is based on the display of coronavirus spike glycoprotein
Autor:
Beibei Wang, D. Zhou, Elizabeth E. Fry, Julian C. Knight, Amy Flaxman, Valdinete Alves do Nascimento, Alexander J. Mentzer, E Barnes, Alex Pauvolid-Corrêa, Sarah C. Gilbert, M Bittaye, Mark A. Williams, Hulswit Rjg., Gavin R. Screaton, Sandra Belij-Rammerstorfer, Chang Liu, Andrew J. Pollard, David R. Hall, Tao Dong, David I. Stuart, Christina Dold, Felipe Gomes Naveca, Wanwisa Dejnirattisai, Elizabeth A. Clutterbuck, Paul Klenerman, Neil G. Paterson, Helen M. Ginn, C Fernandes da Costa, R Levin, Jingshan Ren, Duyvesteyn Hme., Thomas S. Walter, Aekkachai Tuekprakhon, Miles W. Carroll, Donal T. Skelly, R Nutalai, Yuguang Zhao, Thomas A. Bowden, D W Crook, S A Costa Clemens, Marilda M. Siqueira, P Supasa, Susanna Dunachie, S Bibi, Teresa Lambe, Paola Cristina Resende, Cesar Lopez-Camacho, J Slon-Campos, Juthathip Mongkolsapaya, Fabrícia F. Nascimento
Publikováno v:
Cell
Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. However, new strains have emerged with multiple mutations: P.1 from Brazil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ac3bb39f884cef9702bb4016069aa5
https://doi.org/10.1016/j.cell.2021.03.055
https://doi.org/10.1016/j.cell.2021.03.055
Autor:
Christina Dold, Miles W. Carroll, C Mason, David Hall, Eleanor Barnes, Cesar Lopez-Camacho, F. Gomes Naveca, Jingshan Ren, M C Nunes, D. Zhou, David I. Stuart, P Goulder, Elizabeth E. Fry, Neil G. Paterson, Shabir A. Madhi, Juthathip Mongkolsapaya, Amy Flaxman, S A Johnson, Teresa Lambe, Valdinete Alves do Nascimento, Sandra Belij-Rammerstorfer, Alexander J. Mentzer, Helen M. Ginn, Tao Dong, Thomas S. Walter, Donal T. Skelly, Paul Klenerman, Z Ditse, Marilda M. Siqueira, Sarah C. Gilbert, Susanna Dunachie, James C. Knight, Alex Pauvolid-Corrêa, P Supasa, Mark A. Williams, Vicky L. Baillie, N Serafin, C Fernandes da Costa, Yuguang Zhao, Andrew J. Pollard, R Nutalai, S Bibi, T G Ritter, Fabrícia F. Nascimento, M Bittaye, Wanwisa Dejnirattisai, Beibei Wang, Chang Liu, Gavin R. Screaton, Elizabeth A. Clutterbuck, Aekkachai Tuekprakhon, Paola Cristina Resende, J Slon-Campos, S A Costa Clemens, Nigel J. Temperton, Duyvesteyn Hme., D W Crook, K Da Silva, T Malik
Publikováno v:
Cell
SARS-CoV-2 has undergone progressive change with variants conferring advantage rapidly becoming dominant lineages e.g. B.1.617. With apparent increased transmissibility variant B.1.617.2 has contributed to the current wave of infection ravaging the I
Autor:
Derrick W. Crook, Eleanor Barnes, Naomi Coombes, D. Zhou, Jingshan Ren, Duyvesteyn Hme., Bassam Hallis, Alexander J. Mentzer, Christina Dold, Sheila F Lumley, Cesar Lopez-Camacho, Aekkachai Tuekprakhon, Elizabeth E. Fry, Guido C. Paesen, Thomas S. Walter, Donal T. Skelly, Beibei Wang, Helen M. Ginn, David I. Stuart, Chang Liu, Sandra Belij-Rammerstorfer, Julian C. Knight, Susanna Dunachie, Juthathip Mongkolsapaya, S Bibi, Teresa Lambe, Amy Flaxman, Sarah C. Gilbert, P Supasa, Wanwisa Dejnirattisai, Paul Klenerman, M Bittaye, Miles W. Carroll, Tao Dong, Sue Charlton, R Levin, R Nutalai, Yuguang Zhao, William James, Gavin R. Screaton, Kevin R. Bewley, Elizabeth A. Clutterbuck, J Slon-Campos, Andrew J. Pollard
Publikováno v:
Cell
The race to produce vaccines against SARS-CoV-2 began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK–B.1.1.7, South Africa
Autor:
Aekkachai Tuekprakhon, Amy Flaxman, Sarah C. Gilbert, Mark A. Williams, Teresa Lambe, Guido C. Paesen, J Slon-Campos, Eleanor Barnes, William James, N Gent, Naomi Coombes, I Shaik, Sue Charlton, Andrew J. Pollard, Christina Dold, Sheila F Lumley, A Sienkiewicz, Bassam Hallis, Alexander J. Mentzer, D. Zhou, Elizabeth E. Fry, R Nutalai, Kerry J Godwin, Gavin R. Screaton, Cesar Lopez-Camacho, Kevin R. Bewley, Paul Klenerman, Elizabeth A. Clutterbuck, Miles W. Carroll, Wanwisa Dejnirattisai, S Bibi, Beibei Wang, Juthathip Mongkolsapaya, Susanna Dunachie, Sandra Belij-Rammerstorfer, Jingshan Ren, David R. Hall, R Levin, Thomas S. Walter, Donal T. Skelly, Natalie Baker, Helen M. Ginn, P Supasa, Tao Dong, Chang Liu, Neil G. Paterson, Yuguang Zhao, Julian C. Knight, Holly E. Humphries, M Bittaye, David I. Stuart, D W Crook, Duyvesteyn Hme.
Publikováno v:
Cell
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
SARS-CoV-2 has caused over 2M deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant
Autor:
Pramila Rijal, Loic Carrique, Neil G. Paterson, Elizabeth E. Fry, Chen C-P., Huang K-Ya., Alain Townsend, Gavin R. Screaton, Reinis R. Ruza, Shah Pnm., D. Zhou, Karen R. Buttigieg, Miles W. Carroll, William James, Raymond J. Owens, J. Huo, James H. Naismith, Jingshan Ren, Huang Y-C., Kerry J Godwin, Lin T-Y., Shih S-R., Chen T-H., Javier Gilbert-Jaramillo, Huang C-G., Cheng S-H., Julia A. Tree, Tomas Malinauskas, David I. Stuart, Che Ma, R F Donat, Julika Radecke, Tiong Kit Tan, Michael L. Knight, P Supasa, Cheng C-Y., Duyvesteyn Hme., Juthathip Mongkolsapaya, Lin Y-C., Yuguang Zhao
Publikováno v:
Nature Structural & Molecular Biology
The COVID-19 pandemic has had unprecedented health and economic impact, but currently there are no approved therapies. We have isolated an antibody, EY6A, from a late-stage COVID-19 patient and show it neutralises SARS-CoV-2 and cross-reacts with SAR
Autor:
Duyvesteyn, HME
Picornaviruses include significant infectious agents and are challenging structural targets owing to their pathogenicity. They share a common architecture, but subtle differences in their structure mediate tissue tropism, receptor binding and uncoati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::173bc7e23dcfa8c60a7d52f782b2e99f
https://ora.ox.ac.uk/objects/uuid:e2fd4ad8-6060-436d-8f54-56547f257e1d
https://ora.ox.ac.uk/objects/uuid:e2fd4ad8-6060-436d-8f54-56547f257e1d
Autor:
Michael L. Knight, Pramila Rijal, Maud Dumoux, David I. Stuart, Loic Carrique, J. Huo, Lucile Moynié, Michael J. Elmore, Philip N. Ward, Miriam Weckener, Shah Pnm., Javier Gilbert-Jaramillo, Daniel K. Clare, A. Le Bas, Miles W. Carroll, Julia A. Tree, Reinis R. Ruza, Yuguang Zhao, Jingshan Ren, Tomas Malinauskas, Karen R. Buttigieg, H. Mikolajek, Raymond J. Owens, V K Vogirala, William James, James H. Naismith, Duyvesteyn Hme., Julika Radecke, Alain Townsend, Tiong Kit Tan, Naomi Coombes, D. Zhou, Peter J. Harrison
Publikováno v:
Nature Structural & Molecular Biology
The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) recep
Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
Autor:
Michael J. Elmore, Peter J. Harrison, Duyvesteyn Hme., Karen R. Buttigieg, William James, Michael L. Knight, Audrey Le Bas, David I. Stuart, Julia A. Tree, James H. Naismith, Miriam Weckener, Lucile Moynié, Raymond J. Owens, Tomas Malinauskas, Jiangdong Huo, Daniel K. Clare, Philip N. Ward, Reinis R. Ruza, Alain Townsend, H. Mikolajek, Jingshan Ren, Shah Pnm., Pramila Rijal, Javier Gilbert-Jaramillo, Loic Carrique, Miles W. Carroll, Naomi Coombes, Maud Dumoux, D. Zhou, Julika Radecke, Tiong Kit Tan, Yuguang Zhao, V K Vogirala
Publikováno v:
Nature Structural & Molecular Biology
Autor:
Liu C; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Zhou D; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK., Dijokaite-Guraliuc A; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Supasa P; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK., Ginn HM; Centre for Free Electron Laser Science, Hamburg, Germany., Selvaraj M; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Mentzer AJ; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Das R; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., de Silva TI; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Ritter TG; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Plowright M; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Newman TAH; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Stafford L; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kronsteiner B; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK., Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich Chatham Maritime, Kent ME4 4TB, UK., Lui Y; Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Fellermeyer M; Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Goulder P; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Department of Paediatrics, University of Oxford, Oxford, UK., Klenerman P; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dunachie SJ; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; NDM Centre for Global Health Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Barton MI; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Kutuzov MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Dushek O; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK. Electronic address: liz@strubi.ox.ac.uk., Mongkolsapaya J; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. Electronic address: juthathip.mongkolsapaya@well.ox.ac.uk., Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK. Electronic address: ren@strubi.ox.ac.uk., Stuart DI; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK; Sir William Dunn School of Pathology, Oxford, UK. Electronic address: dave@strubi.ox.ac.uk., Screaton GR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address: gavin.screaton@medsci.ox.ac.uk.
Publikováno v:
Cell reports. Medicine [Cell Rep Med] 2024 May 21; Vol. 5 (5), pp. 101553. Date of Electronic Publication: 2024 May 08.