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Akademický článek

The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivityResearch in context

Autor: Mégane Willems, Malik Hamaidia, Alexis Fontaine, Mélanie Grégoire, Louise Halkin, Lea Vilanova Mañá, Roxane Terres, Majeed Jamakhani, Sophie Deshayes, Yves Brostaux, Vincent Heinen, Renaud Louis, Bernard Duysinx, Didier Jean, Eric Wasielewski, Arnaud Scherpereel, Christophe Blanquart, Luc Willems

Publikováno v: EBioMedicine, Vol 109, Iss , Pp 105418- (2024)

Summary: Background: In mesothelioma (MPM), clinical evidence indicates that the absolute eosinophil count negatively correlates with overall survival and response to standard chemotherapy. Since eosinophils poorly infiltrate MPM tumours, we hypothes

Externí odkaz: https://doaj.org/article/22958e461f874e31ac714e0c88cab42f

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Identification of CT radiomic features robust to acquisition and segmentation variations for improved prediction of radiotherapy-treated lung cancer patient recurrence

Autor: Thomas Louis, François Lucia, François Cousin, Carole Mievis, Nicolas Jansen, Bernard Duysinx, Romain Le Pennec, Dimitris Visvikis, Malik Nebbache, Martin Rehn, Mohamed Hamya, Margaux Geier, Pierre-Yves Salaun, Ulrike Schick, Mathieu Hatt, Philippe Coucke, Pierre Lovinfosse, Roland Hustinx

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract The primary objective of the present study was to identify a subset of radiomic features extracted from primary tumor imaged by computed tomography of early-stage non-small cell lung cancer patients, which remain unaffected by variations in

Externí odkaz: https://doaj.org/article/cb821f285cad41d2b52951cd322e47db

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Topology Optimization for Large-Scale Additive Manufacturing: Generating designs tailored to the deposition nozzle size

Autor: Fernández, Eduardo, Ayas, Can, Langelaar, Matthijs, Duysinx, Pierre

Publikováno v: Virtual and Physical Prototyping (2021): 1-25

Additive Manufacturing (AM) processes intended for large scale components deposit large volumes of material to shorten process duration. This reduces the resolution of the AM process, which is typically defined by the size of the deposition nozzle. I

Externí odkaz: http://arxiv.org/abs/2105.08115

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Analytical relationships for imposing minimum length scale in the robust Topology Optimization formulation

Autor: Trillet, Denis, Duysinx, Pierre, Fernández, Eduardo

The robust topology optimization formulation that introduces the eroded and dilated versions of the design has gained increasing popularity in recent years, mainly because of its ability to produce designs satisfying a minimum length scale. Despite i

Externí odkaz: http://arxiv.org/abs/2101.08605

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Akademický článek

Predictive clinical and dosimetric parameters for risk of relapse in early-stage non-small cell lung cancer treated by SBRT: A large single institution experience

Autor: François Lucia, Carole Mievis, Nicolas Jansen, Bernard Duysinx, François Cousin, Thomas Louis, Manon Baiwir, Christelle Ernst, Michel Wonner, Roland Hustinx, Pierre Lovinfosse, Philippe Coucke

Publikováno v: Clinical and Translational Radiation Oncology, Vol 45, Iss , Pp 100720- (2024)

Purpose: To evaluate the impact of dosimetric parameters on efficacy of stereotactic body radiation therapy (SBRT) in early-stage non-small cell lung cancer (ES-NSCLC), using Hypofractionated Treatment Effects in the Clinic (HyTEC) reporting standard

Externí odkaz: https://doaj.org/article/c7aee60bbd164468b270ac7cfe7d4571

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Imposing minimum and maximum member size, minimum cavity size, and minimum separation distance between solid members in topology optimization

Autor: Fernández, Eduardo, Yang, Kai-ke, Koppen, Stijn, Alarcón, Pablo, Bauduin, Simon, Duysinx, Pierre

This paper focuses on density-based topology optimization and proposes a combined method to simultaneously impose Minimum length scale in the Solid phase (MinSolid), Minimum length scale in the Void phase (MinVoid) and Maximum length scale in the Sol

Externí odkaz: http://arxiv.org/abs/2003.00263

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Akademický článek

Excess of blood eosinophils prior to therapy correlates with worse prognosis in mesothelioma

Autor: Mégane Willems, Arnaud Scherpereel, Eric Wasielewski, Jo Raskin, Hélène Brossel, Alexis Fontaine, Mélanie Grégoire, Louise Halkin, Majeed Jamakhani, Vincent Heinen, Renaud Louis, Bernard Duysinx, Malik Hamaidia, Luc Willems

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundOnly a fraction of patients with malignant pleural mesothelioma (MPM) will respond to chemo- or immunotherapy. For the majority, the condition will irremediably relapse after 13 to 18 months. In this study, we hypothesized that patients’

Externí odkaz: https://doaj.org/article/b0aa66a4104343c0ad35e8ad8b16efe7

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