Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Duygu Kuzuoğlu-Öztürk"'
Autor:
Annamaria Sgromo, Tobias Raisch, Praveen Bawankar, Dipankar Bhandari, Ying Chen, Duygu Kuzuoğlu-Öztürk, Oliver Weichenrieder, Elisa Izaurralde
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targ
Externí odkaz:
https://doaj.org/article/dd58df3ad8ed437f920ca025930a2428
Autor:
Swantje, Liedmann, Xueyan, Liu, Clifford S, Guy, Jeremy Chase, Crawford, Diego A, Rodriguez, Duygu, Kuzuoğlu-Öztürk, Ao, Guo, Katherine C, Verbist, Jamshid, Temirov, Mark J, Chen, Davide, Ruggero, Hui, Zhang, Paul G, Thomas, Douglas R, Green
Publikováno v:
Mol Cell
Activated CD8(+) T lymphocytes differentiate into heterogeneous subsets. Using super-resolution imaging, we found that prior to the first division, dynein-dependent vesicular transport polarized active TORC1 towards the microtubule-organizing center
Autor:
Swantje Liedmann, Xueyan Liu, Clifford S. Guy, Jeremy Chase Crawford, Diego A. Rodriguez, Duygu Kuzuoğlu-Öztürk, Ao Guo, Katherine C. Verbist, Jamshid Temirov, Mark J. Chen, Davide Ruggero, Hui Zhang, Paul G. Thomas, Douglas R. Green
Publikováno v:
Molecular Cell. 82:2401-2414.e9
Autor:
Martina Rama, Jacob Weiss, Gary G. Chiang, Luke A. Gilbert, Duygu Kuzuoğlu-Öztürk, Emily Devericks, Stephen T. Worland, Davide Ruggero, Zhiqiang Hu, Steven E. Brenner, Hani Goodarzi
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109321-(2021)
Cell reports
Cell reports, vol 35, iss 13
Cell reports
Cell reports, vol 35, iss 13
SUMMARY The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancient protein required for translation of all eukaryotic genomes, is a surprising yet potent oncogenic driver. The genetic interactions that maintain the
Autor:
Pedro Beltrao, Phillip P. Sharp, Nevan J. Krogan, Sabrina J. Fletcher, Saker Klippsten, Trey Ideker, Melanie Ott, Bryan L. Roth, Xi Liu, Devin A. Cavero, Djoshkun Shengjuler, Christopher J.P. Mathy, Jason C.J. Chang, Theodore L. Roth, Hannes Braberg, Claudia Hernandez-Armenta, Lisa Miorin, Jyoti Batra, Shizhong Dai, Maliheh Safari, Brian K. Shoichet, Danish Memon, Tia A. Tummino, Marco Vignuzzi, Mark von Zastrow, Manon Eckhardt, Alan D. Frankel, Qiongyu Li, Tanja Kortemme, Nicole A. Wenzell, Zun Zar Chi Naing, Ferdinand Roesch, Nastaran Sadat Savar, Mathieu Hubert, Xi Ping Huang, Elena Moreno, Danica Galonić Fujimori, Jeffrey Z. Guo, Natalia Jura, Kirsten Obernier, Kliment A. Verba, Harmit S. Malik, Hao-Yuan Wang, Michael McGregor, Melanie J. Bennett, Julia Noack, Gwendolyn M. Jang, Paige Haas, Alice Mac Kain, Daniel J. Saltzberg, Mehdi Bouhaddou, Ziyang Zhang, Yongfeng Liu, Inigo Barrio-Hernandez, Yiming Cai, Kris M. White, Kelsey M. Haas, Maya Modak, Stephanie A. Wankowicz, Raphael Trenker, Kevan M. Shokat, Fatima S. Ugur, Shiming Peng, Sai J. Ganesan, Shaeri Mukherjee, Yuan Zhou, Minkyu Kim, John D. Gross, Jack Taunton, Alicia L. Richards, John S. Chorba, Margaret Soucheray, Danielle L. Swaney, Benjamin J. Polacco, Alan Ashworth, Wenqi Shen, Adolfo García-Sastre, Merve Cakir, Ujjwal Rathore, Kala Bharath Pilla, Michael C. O’Neal, Ying Shi, Kevin Lou, Cassandra Koh, Stephen N. Floor, Davide Ruggero, Ilsa T Kirby, Srivats Venkataramanan, Ruth Hüttenhain, Olivier Schwartz, Beril Tutuncuoglu, Christophe d'Enfert, Jose Liboy-Lugo, David A. Agard, Charles S. Craik, Veronica V. Rezelj, Tina Perica, Matthew P. Jacobson, Lorenzo Calviello, Eric Verdin, Yizhu Lin, Jiankun Lyu, Jiewei Xu, Joseph Hiatt, Andrej Sali, Oren S. Rosenberg, Markus Bohn, David E. Gordon, James S. Fraser, Sara Brin Rosenthal, Duygu Kuzuoğlu-Öztürk, Robyn M. Kaake, Jacqueline M. Fabius, Matthew J. O’Meara, Quang Dinh Tran, Advait Subramanian, Thomas Vallet, Bjoern Meyer, James E. Melnyk, Robert M. Stroud, Helene Foussard, Rakesh Ramachandran, David J. Broadhurst, Janet M. Young, Michael Emerman
Publikováno v:
Nature
Schizophrenia Research
Schizophrenia Research
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individ
Autor:
Steven E. Brenner, Davide Ruggero, Hani Goodarzi, Zhiqiang Hu, Emily Devericks, Gary G. Chiang, Jacob Weiss, Stephen T. Worland, Luke A. Gilbert, Martina Rama, Duygu Kuzuoğlu-Öztürk
Publikováno v:
SSRN Electronic Journal.
The major cap binding protein eIF4E, an ancient protein required for translation of all eukaryotic genomes, is a surprising yet potent oncogenic driver. The genetic interactions that maintain the oncogenic activity of this key translation factor rema
Autor:
Duygu Kuzuoğlu-Öztürk, Oliver Weichenrieder, Elisa Izaurralde, Chung Te Chang, Praveen Bawankar, Belinda Loh, Andreas Boland, Ying Chen
Publikováno v:
Molecular Cell. 54(5):737-750
CCR4-NOT is a major effector complex in miRNA-mediated gene silencing. It is recruited to miRNA targets through interactions with tryptophan (W)-containing motifs in TNRC6/GW182 proteins and is required for both translational repression and degradati
Autor:
Dipankar Bhandari, Ramona Weber, Tobias Raisch, Cátia Igreja, Maria Fauser, Aoife Hanet, Duygu Kuzuoğlu-Öztürk, Vincenzo Ruscica, Chung Te Chang, Felix Räsch, Lara Wohlbold
Publikováno v:
Life Science Alliance
The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs.
Eukaryotic superfamily (SF) 1 helicases have been implicated in various
Eukaryotic superfamily (SF) 1 helicases have been implicated in various
Autor:
Annamaria Sgromo, Ying Chen, Elisa Izaurralde, Tobias Raisch, Praveen Bawankar, Oliver Weichenrieder, Dipankar Bhandari, Duygu Kuzuoğlu-Öztürk
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target degradation through the recruitment of the CCR4-NOT deadenylase complex and are implicated in the prevention of autoimmunity. Roquin1 recruits CCR4-NOT via a C-terminal
Autor:
Lara Wohlbold, Tobias Raisch, Duygu Kuzuoğlu-Öztürk, Ying Chen, Oliver Weichenrieder, Stefanie Jonas, Elisa Izaurralde, Andreas Boland
Publikováno v:
Nature structuralmolecular biology. 20(11)
The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1,