Výsledky vyhledávání - "Duygu Ercan Laguna"

Akademický článek

eNAMPT/TLR4 inflammatory cascade activation is a key contributor to SLE Lung vasculitis and alveolar hemorrhage

Autor: Gantsetseg Tumurkhuu, Nancy G. Casanova, Carrie L. Kempf, Duygu Ercan Laguna, Sara M. Camp, Jargalsaikhan Dagvadorj, Jin H. Song, Vivian Reyes Hernon, Cristina Travelli, Erica N. Montano, Jeong Min Yu, Mariko Ishimori, Daniel J. Wallace, Saad Sammani, Caroline Jefferies, Joe G.N. Garcia

Publikováno v: Journal of Translational Autoimmunity, Vol 6, Iss , Pp 100181- (2023)

Rationale: Effective therapies to reduce the severity and high mortality of pulmonary vasculitis and diffuse alveolar hemorrhage (DAH) in patients with systemic lupus erythematosus (SLE) is a serious unmet need. We explored whether biologic neutraliz

Externí odkaz: https://doaj.org/article/8b7438a4b64745b39ec0c97c6e32db85

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Akademický článek

Neutrophils Contribute to ER Stress in Lung Epithelial Cells in the Pristane-Induced Diffuse Alveolar Hemorrhage Mouse Model

Autor: Gantsetseg Tumurkhuu, Duygu Ercan Laguna, Richard E. Moore, Jorge Contreras, Gabriela De Los Santos, Luisa Akaveka, Erica N. Montano, Yizhou Wang, Mariko Ishimori, Swamy Venuturupalli, Lindsy J. Forbess, Barry R. Stripp, Daniel J. Wallace, Caroline A. Jefferies

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Diffuse alveolar hemorrhage (DAH), although rare, is a life-threatening complication of systemic lupus erythematosus (SLE). Little is known about the pathophysiology of DAH in humans, although increasingly neutrophils, NETosis and inflammatory monocy

Externí odkaz: https://doaj.org/article/16d6495b0a4a4ec9b252b49043fdb93d

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Akademický článek

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Autor: Gantsetseg Tumurkhuu, Shuang Chen, Erica N. Montano, Duygu Ercan Laguna, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Timothy R. Crother, Mariko Ishimori, Daniel J. Wallace, Caroline A. Jefferies, Moshe Arditi

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repa

Externí odkaz: https://doaj.org/article/804a8420fafe4285aba0bf129953d581

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Akademický článek

Label-Free QCM Immunosensor for the Detection of Ochratoxin A

Autor: Şerife Şeyda Pirinçci, Özlem Ertekin, Duygu Ercan Laguna, Fehime Şeyma Özen, Zafer Ziya Öztürk, Selma Öztürk

Publikováno v: Sensors, Vol 18, Iss 4, p 1161 (2018)

Ochratoxin A (OTA) is a potent mycotoxin that poses a risk in food and feed moieties and subject to worldwide regulation. Laboratory-based analytical methods are traditionally employed for reliable OTA quantification, but these methods cannot provide

Externí odkaz: https://doaj.org/article/7c37b85eba25458598c821c7401ffe95

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