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Variable Response to Antifibrinolytics Correlates with Blood-loss and Transfusion in Posterior Spinal Fusion.

Autor: Gibson BHY; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., Duvernay MT; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA., McKeithan LJ; Vanderbilt University School of Medicine, Nashville, TN, USA., Benvenuti TA; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA., Warhoover TA; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA., Martus JE; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, 1155 MRBIV, 2215B Garland Ave, Nashville, TN, 37232, USA., Mencio GA; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, 1155 MRBIV, 2215B Garland Ave, Nashville, TN, 37232, USA., Emerson BR; Department of Pediatric Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA., Moore-Lotridge SN; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Borst AJ; Department of Pediatrics, Vanderbilt University Medical Center, 1155 MRBIV, 2215B Garland Ave, Nashville, TN, 37232, USA.; Department of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA., Schoenecker JG; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA. jon.schoenecker@vumc.org.; Department of Orthopaedics, Vanderbilt University Medical Center, Nashville, TN, USA. jon.schoenecker@vumc.org.; Department of Pediatrics, Vanderbilt University Medical Center, 1155 MRBIV, 2215B Garland Ave, Nashville, TN, 37232, USA. jon.schoenecker@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. jon.schoenecker@vumc.org.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. jon.schoenecker@vumc.org.; Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN, USA. jon.schoenecker@vumc.org.

Publikováno v: Spine deformity [Spine Deform] 2022 Jul; Vol. 10 (4), pp. 841-851. Date of Electronic Publication: 2022 Mar 05.

Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.

Autor: Bertron JL; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Duvernay MT; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Mitchell SG; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Smith ST; Chemical and Physical Biology Program, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Maeng JG; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Blobaum AL; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Davis DC; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Institute for Drug Discovery, Leipzig University, Saxony 04109, Germany., Hamm HE; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States., Lindsley CW; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2021 Dec 15; Vol. 12 (24), pp. 4524-4534. Date of Electronic Publication: 2021 Dec 02.

Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease.

Autor: Gibson BHY; Department of Pharmacology Vanderbilt University Nashville TN USA., Duvernay MT; Department of Pharmacology Vanderbilt University Nashville TN USA.; Department of Orthopaedics Vanderbilt University Medical Center Nashville TN USA.; Center for Bone Biology Vanderbilt University Medical Center Nashville TN USA., Moore-Lotridge SN; Department of Orthopaedics Vanderbilt University Medical Center Nashville TN USA., Flick MJ; Department of Pathology and Laboratory Medicine University of North Carolina-Chapel Hill NC USA.; UNC Blood Research Center Chapel Hill NC USA., Schoenecker JG; Department of Pharmacology Vanderbilt University Nashville TN USA.; Department of Orthopaedics Vanderbilt University Medical Center Nashville TN USA.; Center for Bone Biology Vanderbilt University Medical Center Nashville TN USA.; Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville TN USA.; Department of Pediatrics Vanderbilt University Medical Center Nashville TN USA.

Publikováno v: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2020 Jun 14; Vol. 4 (4), pp. 469-480. Date of Electronic Publication: 2020 Jun 14 (Print Publication: 2020).

The role of coagulation and platelets in colon cancer-associated thrombosis.

Autor: Mitrugno A; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon.; Division of Hematology & Medical Oncology, Oregon Health & Science University , Portland, Oregon., Tassi Yunga S; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University , Portland, Oregon.; Cancer Early Detection & Advanced Research Center, Oregon Health & Science University , Portland, Oregon., Sylman JL; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon.; VA Palo Alto Health Care System, Palo Alto, California.; Canary Center at Stanford, Department of Radiology, Stanford University School of Medicine , Stanford, California., Zilberman-Rudenko J; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon., Shirai T; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon., Hebert JF; Department of Pathology, Oregon Health & Science University , Portland, Oregon., Kayton R; Department of Pathology, Oregon Health & Science University , Portland, Oregon., Zhang Y; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon., Nan X; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon., Shatzel JJ; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon.; Division of Hematology & Medical Oncology, Oregon Health & Science University , Portland, Oregon., Esener S; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University , Portland, Oregon.; Cancer Early Detection & Advanced Research Center, Oregon Health & Science University , Portland, Oregon., Duvernay MT; Department of Pharmacology, Vanderbilt University School of Medicine , Nashville, Tennessee., Hamm HE; Department of Pharmacology, Vanderbilt University School of Medicine , Nashville, Tennessee., Gruber A; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon., Williams CD; School of Pharmacy, Oregon State University , Portland, Oregon., Takata Y; College of Public Health & Human Science, Oregon State University , Corvallis, Oregon., Armstrong R; Knight Cancer Institute, Oregon Health & Science University , Portland, Oregon.; Cancer Early Detection & Advanced Research Center, Oregon Health & Science University , Portland, Oregon., Morgan TK; Department of Pathology, Oregon Health & Science University , Portland, Oregon., McCarty OJT; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University , Portland, Oregon.; Division of Hematology & Medical Oncology, Oregon Health & Science University , Portland, Oregon.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2019 Feb 01; Vol. 316 (2), pp. C264-C273. Date of Electronic Publication: 2018 Nov 21.