Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dustyn A. Barnette"'
Autor:
Dakota L. Pouncey, Dustyn A. Barnette, Riley W. Sinnott, Sarah J. Phillips, Noah R. Flynn, Howard P. Hendrickson, S. Joshua Swamidass, Grover P. Miller
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Coumadin (R/S-warfarin) anticoagulant therapy is highly efficacious in preventing the formation of blood clots; however, significant inter-individual variations in response risks over or under dosing resulting in adverse bleeding events or ineffectiv
Externí odkaz:
https://doaj.org/article/a8dec47d9bf6442485f60c67345fb8f1
Autor:
Qiang Shi, Ayesha Arefin, Lijun Ren, Katy S. Papineau, Dustyn A. Barnette, Laura K. Schnackenberg, Jessica J. Hawes, Mark Avigan, Donna L. Mendrick, Lorna Ewart, Janey Ronxhi
Publikováno v:
Current Protocols. 2
Drug-induced liver injury (DILI) is a significant public health issue, but standard animal tests and clinical trials sometimes fail to predict DILI due to species differences and the relatively low number of human subjects involved in preapproval stu
Autor:
Noah R. Flynn, Gunnar Boysen, Mary A. Davis, Anirudh S. Pidugu, Dustyn A. Barnette, S. Joshua Swamidass, Grover P. Miller
Publikováno v:
Chem Res Toxicol
Lamisil (terbinafine) is an effective, widely prescribed antifungal drug that causes rare idiosyncratic hepatotoxicity. The proposed toxic mechanism involves a reactive metabolite, 6,6-dimethyl-2-hepten-4-ynal (TBF-A), formed through three N-dealkyla
Autor:
Dustyn A. Barnette, Keith F. Woeltje, S. Joshua Swamidass, Arghya Datta, Noah R. Flynn, Grover P. Miller
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 7, p e1009053 (2021)
PLoS Computational Biology, Vol 17, Iss 7, p e1009053 (2021)
Drug-drug interactions account for up to 30% of adverse drug reactions. Increasing prevalence of electronic health records (EHRs) offers a unique opportunity to build machine learning algorithms to identify drug-drug interactions that drive adverse e
Autor:
Dustyn A. Barnette, Grover P. Miller, S. Joshua Swamidass, Mary A. Schleiff, Arghya Datta, Noah R. Flynn
Publikováno v:
Toxicol Lett
Meloxicam is a thiazole-containing NSAID that was approved for marketing with favorable clinical outcomes despite being structurally similar to the hepatotoxic sudoxicam. Introduction of a single methyl group on the thiazole results in an overall low
Autor:
Gunnar Boysen, Mary A. Davis, Grover P. Miller, S. Joshua Swamidass, Na Le Dang, Dustyn A. Barnette, Tyler B. Hughes, Anirudh S. Pidugu
Publikováno v:
Biochemical Pharmacology. 156:10-21
Lamisil (terbinafine) may cause idiosyncratic liver toxicity through a proposed toxicological mechanism involving the reactive metabolite 6,6-dimethyl-2-hepten-4-ynal (TBF-A). TBF-A toxicological relevance remains unclear due to a lack of identificat
Publikováno v:
Toxicological Sciences. 157:429-437
Exposure to the water pollutant trichloroethylene (TCE) can promote autoimmunity in both humans and rodents. Using a mouse model we have shown that chronic adult exposure to TCE at 500 μg/ml in drinking water generates autoimmune hepatitis in female
Autor:
Noah R. Flynn, Grover P. Miller, Laura R. Osborn, Mary A. Schleiff, Dustyn A. Barnette, Matthew K. Matlock, S. Joshua Swamidass
Publikováno v:
Toxicology
Thiazoles are biologically active aromatic heterocyclic rings occurring frequently in natural products and drugs. These molecules undergo typically harmless elimination; however, a hepatotoxic response can occur due to multistep bioactivation of the
Autor:
Dustyn A. Barnette, S. Joshua Swamidass, Noah R. Flynn, Anirudh S. Pidugu, Mary A. Davis, Grover P. Miller
Publikováno v:
Biochem Pharmacol
Terbinafine N-dealkylation pathways result in formation of 6,6-dimethyl-2-hepten-4-ynal (TBF-A), a reactive allylic aldehyde, that may initiate idiosyncratic drug-induced liver toxicity. Previously, we reported on the importance of CYP2C19 and 3A4 as
Autor:
Grover P. Miller, Linda P. Desrochers, Dustyn A. Barnette, Robert Nshimiyimana, Dakota L. Pouncey, Bryce P. Johnson, Thomas E. Goodwin
Coumadin (rac-warfarin) is the most commonly used anticoagulant in the world; however, its clinical use is often challenging because of its narrow therapeutic range and interindividual variations in response. A critical contributor to the uncertainty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e7911173bf59a859dddd3edf5eca58
https://europepmc.org/articles/PMC5539582/
https://europepmc.org/articles/PMC5539582/