A Case Study of a Prymnesium parvum Harmful Algae Bloom in the Ohio River Drainage: Impact, Recovery and Potential for Future Invasions/Range Expansion

Autor: Kyle J. Hartman, David I. Wellman, Joseph W. Kingsbury, Daniel A. Cincotta, Janet L. Clayton, Kevin M. Eliason, Frank A. Jernejcic, Nathaniel V. Owens, Dustin M. Smith

Publikováno v: Water, Vol 13, Iss 22, p 3233 (2021)

Inland waters provide valuable ecosystem goods and services and are intrinsically linked to downstream coastal areas. Water quality impairments that lead to harmful algal blooms damage valuable commercial and recreational fishing economies, threaten

Externí odkaz: https://doaj.org/article/b7228dbbfcd04d4f8f1b2473f222a5d4

Identification of Potent Reverse Indazole Inhibitors for HPK1

Autor: Dustin M Smith, Zangwei Xu, Joey L. Methot, Xavier Fradera, Alexander Pasternak, Elsie C Yu, Jennifer Piesvaux, Phieng Siliphaivanh, Brian M. Lacey, Mark Bittinger, Shuhei Kawamura, Charles A. Lesburg, J. Richard Miller, Ping Liu, Haiyan Xu

Publikováno v: ACS Med Chem Lett

[Image: see text] Hematopoietic progenitor kinase (HPK1), a negative regulator of TCR-mediated T-cell activation, has been recognized as a novel antitumor immunotherapy target. Structural optimization of kinase inhibitor 4 through a systematic two-di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e303cf25b4e300aa5e1301e60ba336
https://doi.org/10.1021/acsmedchemlett.0c00672

Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites

Autor: James Baker, Ryan Lutz, Zaikuan J. Yu, Joseph M. Roesner, Peter W. Fan, Dustin M Smith, Yuexia Liang

Publikováno v: Drug Metabolism and Pharmacokinetics. 34:308-316

LC-MS quantification of drug metabolites is sometimes impeded by the availability of internal standards that often requires customized synthesis and/or extensive purification. Although isotopically labeled internal standards are considered ideal for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b47af9c1f24e2236b1bd4277f3c4af0
https://doi.org/10.1016/j.dmpk.2019.05.004

Seasonal Movement Patterns and Distribution of Walleye in a Central Appalachian Hydropower Reservoir

Autor: Dustin M. Smith, Stuart A. Welsh, Corbin D. Hilling

Publikováno v: Yellow Perch, Walleye, and Sauger: Aspects of Ecology, Management, and Culture ISBN: 9783030806774
Yellow Perch, Walleye, and Sauger: Aspects of Ecology, Management, and Culture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c119c5f2fc568d8489da7f17b8ac481
https://doi.org/10.1007/978-3-030-80678-1_8

Effect of substrate size on sympatric sand darter benthic habitat preferences

Autor: Austin A. Rizzo, Dustin M. Smith, Patricia A. Thompson, Stuart A. Welsh

Publikováno v: Journal of Freshwater Ecology, Vol 32, Iss 1, Pp 455-465 (2017)

The western sand darter, Ammocrypta clara, and the eastern sand darter, A. pellucida, are sand-dwelling fishes that have undergone range-wide population declines, presumably owing to habitat loss. Habitat use studies have been conducted for the easte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0ac6650499148744652cc704f94a3b
https://doaj.org/article/ad8343cf0aba4cf781baec6255fb8173