Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dustin Laming"'
Autor:
Mziyanda Mbaba, Laura M. K. Dingle, Ayanda I. Zulu, Dustin Laming, Tarryn Swart, Jo-Anne de la Mare, Heinrich C. Hoppe, Adrienne L. Edkins, Setshaba D. Khanye
Publikováno v:
Molecules, Vol 26, Iss 5, p 1333 (2021)
A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy of the constituent chemical motifs. The st
Externí odkaz:
https://doaj.org/article/f7b90f3c453b4513bf7cd8f86ca3f418
Autor:
Richard M. Beteck, Audrey Jordaan, Ronnett Seldon, Dustin Laming, Heinrich C. Hoppe, Digby F. Warner, Setshaba D. Khanye
Publikováno v:
Molecules, Vol 26, Iss 4, p 1141 (2021)
The cell wall of Mycobacterium tuberculosis (Mtb) has a unique structural organisation, comprising a high lipid content mixed with polysaccharides. This makes cell wall a formidable barrier impermeable to hydrophilic agents. In addition, during host
Externí odkaz:
https://doaj.org/article/b96ee633dccf4561a86ae61e3e0b43a1
Autor:
Richard M. Beteck, Lesetja J. Legoabe, Michelle Isaacs, Setshaba D. Khanye, Dustin Laming, Heinrich C. Hoppe
Publikováno v:
Medicina, Vol 55, Iss 5, p 206 (2019)
Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan diseases that share overlapping endemic areas in sub-Saharan Africa. The causative agent for malaria has developed resistance against all currently deployed ant
Externí odkaz:
https://doaj.org/article/2ccc8f9819824c9690a8b29f2a5091c2
Autor:
Richard M. Beteck, Ronnett Seldon, Audrey Jordaan, Digby F. Warner, Heinrich C. Hoppe, Dustin Laming, Setshaba D. Khanye
Publikováno v:
Molecules, Vol 24, Iss 9, p 1740 (2019)
Co-infection of malaria and tuberculosis, although not thoroughly investigated, has been noted. With the increasing prevalence of tuberculosis in the African region, wherein malaria is endemic, it is intuitive to suggest that the probability of co-in
Externí odkaz:
https://doaj.org/article/1ef9d9e08e7d475cbea912cb415d3467
Publikováno v:
Molecules, Vol 24, Iss 1, p 142 (2019)
Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates. Trypanosomes require folates and pterins f
Externí odkaz:
https://doaj.org/article/014694d74ff8420992571af7ce76db17
Autor:
Maureen Gumbo, Richard M. Beteck, Tawanda Mandizvo, Ronnett Seldon, Digby F. Warner, Heinrich C. Hoppe, Michelle Isaacs, Dustin Laming, Christina C. Tam, Luisa W. Cheng, Nicole Liu, Kirkwood M. Land, Setshaba D. Khanye
Publikováno v:
Molecules, Vol 23, Iss 8, p 2038 (2018)
Due to the increased interest in their application in the treatment of infectious diseases, boron-containing compounds have received a significant coverage in the literature. Herein, a small set of novel cinnamoly-oxaborole amides were synthesized an
Externí odkaz:
https://doaj.org/article/493eced40cd0428381d26864cfc28c92
Autor:
Apelele Ntlantsana, Heinrich C. Hoppe, Tarryn Swart, Farrah D. Khan, Jude M. Przyborski, Dustin Laming, Adrienne L. Edkins, Clinton G. L. Veale
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The regulation of human Arf1 GTPase activity by ArfGEFs that stimulate GDP/GTP exchange and ArfGAPs that mediate GTP hydrolysis has attracted attention for the discovery of Arf1 inhibitors as potential anti-cancer agents. The malaria parasite Plasmod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edfb458bddfc4a64becd402917e6212
http://link.springer.com/article/10.1038/s41598-020-61101-3
http://link.springer.com/article/10.1038/s41598-020-61101-3
Publikováno v:
ChemMedChem. 14:2034-2041
Recently we reported the results of a screen of the Pathogen Box in which we identified 4-(2-amino-5-(4-(methylsulfonyl) phenyl) pyridin-3-yl)-2-methoxyphenol (MMV010576, 1) as our priority antitrypanosomal hit. This compound had previously been iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae33df64a04488f8ad3783aeaf7ca93d
https://doi.org/10.1002/cmdc.201900492
https://doi.org/10.1002/cmdc.201900492
Autor:
Richard M. Beteck, Ronnett Seldon, Dustin Laming, Audrey Jordaan, Heinrich C. Hoppe, Lesetja J. Legoabe, Setshaba D. Khanye, Digby F. Warner
Publikováno v:
MedChemComm. 10:326-331
Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide–hydrazone bond were synthesised and evaluated against Mycobacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddae160cff0c03e2b5127be49655e64c
https://doi.org/10.1039/c8md00480c
https://doi.org/10.1039/c8md00480c
Autor:
Richard M. Beteck, Fostino R. B. Bokosi, Heinrich C. Hoppe, Setshaba D. Khanye, Tendamudzimu Tshiwawa, Dustin Laming
Publikováno v:
Archiv der PharmazieREFERENCES. 354(7)
A rationally designed series of 2-(N-cyclicamino)quinolines coupled with methyl (E)-3-(2/3/4-aminophenyl)acrylates was synthesized and subjected to in vitro screening bioassays for potential antiplasmodial and antitrypanosomal activities against a ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcf5f1ee3bc5b186df5bec88c7349f5
https://pubmed.ncbi.nlm.nih.gov/33710656
https://pubmed.ncbi.nlm.nih.gov/33710656